The binding of guanine–guanine mismatched DNA to naphthyridine dimer immobilized sensor surfaces: kinetic aspects

Self-assembled PEG monolayer based SPR immunosensor for label-free detection of insulin

“…Therefore, molecular affinity interactions occurring at the sensor surface could be detected without using any reporter labels. Since the advent of SPR for biosensors, SPR technique has been explored for detection of a wide range of biological markers relevant to medical diagnosis, food quality, etc., such as cardiac troponin, enterotoxins and microorganisms (Gaus and Hall, 1998;Sonezaki et al, 2000;Homola et al, 2002b;Wei et al, 2003;Cui et al, 2003;Nakatani et al, 2004). Sensitivity of SPR measurement is directly related to the amount and MW of the analyte that binds to the sensor surface, and thus SPR is highly disadvantageous for detection of small molecules (MW < 1 kDa).…”

An electrochemical impedance sensor for simple and specific recognition of G–G mismatches in DNA

“…In previous work, some naphthyridine derivatives displayed excellent recognition for SNPs such as G-G mismatches. [24][25][26][27][28][29][30] The naphthyridine group was shown to form complementary hydrogen bonds with the guanine base. Bi-functional probes containing both an electrochemically active group (ferrocenyl) and a DNA binding organic molecule through the condensation of carboxyl and amine have been developed for the electrochemical detection of DNA (including G-G mismatches and CGG-repeat DNA) based on current changes.…”

Better Sensing through Stacking: The Role of Non-Covalent Interactions in Guanine-Binding Sensors

“…Thus, 2-acetamido-1,8-naphthyridine (1) provides an excellent biomimetic hydrogen-bonding partner for guanine, forming the backbone of the sensors developed by Fang et al 44 and others. [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]45 3.2. Fang's Fluorescent Sensor.…”