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Multiple protein components in gingival crevicular fluid were analysed at the same time using mass spectrometry, and this approach may be useful for the diagnosis of periodontal diseases.

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, Non-member, Hiroyuki Iwasaka ＊5, Non-member The endocrine-disrupting chemicals affect the functioning of hormones of animals and are called "environmental hormones". They exist in various environments at very low concentrations in the range of ppt to ppb levels. Thus, highly sensitive determination of environmental hormones with high selectivity is indispensable in regulating the ecosystem, and the instrumentation that allows the on-site analysis of environmental hormones is paid much attention. In this research project, we are aiming at development of new optical immunosensing system for highly sensitive, selective, on-site and simultaneous detection of several environmental hormones at low cost. We report here the results of our research investigations on application of immunosensing technique to highly sensitive detection of environmental hormones, preparation of monoclonal antibodies, fabrication of the microchannel, miniaturization of the surface-plasmon-resonance detector, design of the compact total-sensing-system.