The beneficial effect of the sap of<i>Acer mono</i>in an animal with low-calcium diet-induced osteoporosis-like symptoms

Lee, Geun‐Shik; Byun, Hyuk-Soo; Kim, Man-Hee; Ko, Sang-Hwan; Jung, Eui‐Man; Gwak, Ki-Seob; Choi, In‐Gyu; Kang, Ha‐Young; Jo, Hyun-Jin; Lee, Hak‐Ju; Jeung, Eui‐Bae

doi:10.1017/s0007114508959195

Cited by 20 publications

(15 citation statements)

References 38 publications

(45 reference statements)

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“…Vitamin C and plant hormone content (mg/l) of the sap of Acer okamotoanum. compared it to commercial spring water (8). Our study showed that potassium, calcium, and magnesium are present at high levels in A. okamotoanum sap.…”

Section: Discussionmentioning

confidence: 84%

The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats

Yoo

Jung²,

Kang³

et al. 2011

Int J Mol Med

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Abstract. In the present study, we examined whether Acer okamotoanum (A. okamotoanum) sap decreased the serum alcohol and acetaldehyde levels after acute ethanol treatment in a rat model. Male rats were orally administered 25, 50 or 100% A. okamotoanum sap 30 min prior to oral challenge with 3 ml of ethanol (15 ml/kg of a 20% ethanol solution in water), and the blood concentrations of alcohol and acetaldehyde were analyzed up to 7 h after the treatment. Pre-treatment with the sap significantly decreased the blood ethanol and acetaldehyde concentrations after 5 h when compared with ethanol treatment alone (a negative control). The expression levels of liver alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) mRNA were increased significantly in animals pre-treated with A. okamotoanum sap when compared with negative and positive controls. The data suggest that sap pretreatment enhanced the alcohol metabolism rate in the rat liver. To investigate the involvement of mitochondrial regulation in the ethanol-induced hepatocyte apoptosis, we carried out an immunohistochemical analysis of Bax and Bcl-2. Pre-treatment with sap significantly decreased Bax expression and increased Bcl-2 expression 7 h after ethanol administration when compared with the negative control. The data suggest that A. okamotoanum sap pre-treatment may reduce the alcohol-induced oxidative stress in the rat liver.

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Section: Discussionmentioning

confidence: 84%

The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats

Yoo

Jung²,

Kang³

et al. 2011

Int J Mol Med

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“…All the animals were housed in polycarbonate cages and acclimated in an environmentally controlled room (23±2˚C; relative humidity, 50±10%; frequent ventilation; and a 12-h light/dark cycle) prior to use as previously described (12). C. obtusa essential oil used in this study was provided by Enbita Co., Ltd. (Seoul, Korea) and was produced through steam distillation of pruned twigs and leaves of the C. obtusa tree, according to previously described methods (13).…”

Section: Animals and Treatmentmentioning

confidence: 99%

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Kang

Yang

et al. 2013

Molecular Medicine Reports

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Abstract. Essential oils are concentrated hydrophobic liquids containing volatile aromatic compounds from plants. In the present study, the essential oil of Chamaecyparis obtusa (C. obtusa), which is commercially used in soap, toothpaste and cosmetics, was extracted. Essential oil extracted from C. obtusa contains several types of terpenes, which have been shown to have anti-oxidative and anti-inflammatory effects. In the present study, we examined the anti-inflammatory effects of C. obtusa essential oil in vivo and in vitro following the induction of inflammation by lipopolysaccharides (LPS) in rats. While LPS induced an inflammatory response through the production of prostaglandin E 2 (PGE 2 ) in the blood and peripheral blood mononuclear cells (PMNCs), these levels were reduced when essential oil was pre-administered. Additionally, the mechanism of action underlying the anti-inflammatory effects of C. obtusa essential oil was investigated by measuring the mRNA expression of inflammation-associated genes. LPS treatment significantly induced the expression of transforming growth factor α (TNFα) and cyclooxygenase-2 (COX-2) in rats, while C. obtusa essential oil inhibited this effect. Taken together, our results demonstrate that C. obtusa essential oil exerts anti-inflammatory effects by regulating the production of PGE 2 and TNFα gene expression through the COX-2 pathway. These findings suggest that C. obtusa essential oil may constitute a novel source of anti-inflammatory drugs.

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“…sap (AmMs) has been used in East Asian countries for centuries due to its anti-osteoporosis effects (13); however, traditional East Asian medical literature claims that the sap has potential anti-oxidative and immunomodulatory efects (14,15). Previous in vitro and in vivo studies have confirmed that constituents from AmMs have anti-osteoporosis effects by increasing calcium ion absortion (13), but no prior study has investigated whether or not AmMs has gastroprotective effects.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration

Park

Son

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. Acer mono Max. sap (AmMs) is called 'Gol-Li-Su' or 'Go-Lo-Soe' in Korean, which means 'water beneficial to the bones'. It is reported that the sap contains several types of minerals and sugars. In particular, the calcium concentration of the sap is 36.5 times higher than that of commercial mineral water. Apart from its anti-osteoporosis effect, no reports have addressed the biological activities of AmMs against degenerative diseases. In the present study, we investigated whether AmMs alleviates gastric ulcer-related symptoms in a stress-induced mouse model. To assess the effect of AmMs on gastric ulcer-like symptoms, we carried out a water immersion restraint (WIRE) test and found that AmMs has potential in alleviating gastric ulcers in a concentration-dependent manner. These results indicate that the nutritional factors of the sap mitigate the gastric ulcer-related symptoms caused by stress-induced gastric lesions in mice. AmMs-treated mice exhibited a significant decrease in the ulcer index as compared to those treated with omeprazole or L-arginine. To examine one potential mechanism underlying this effect, we performed reverse transcription-polymerase chain reaction to ascertain whether molecular markers were associated with the mitigation of the gastric lesions. Epithelial and/or tissue nitric oxide synthase (NOS) was assessed to determine whether or not the genes were down-regulated dose-dependently by the sap. The levels of these enzymes were found to be lower in the tissue samples treated with AmMs compared with the levels in the control samples. These findings collectively suggest that AmMs significantly protects the gastric mucosa against WIRE stress-induced gastric lesions, at least in part, by alleviating inducible NOS and/or neuronal NOS expression. IntroductionAcute gastric mucosal injury is a serious clinical problem worldwide. The symptoms cause severe gastric ulceritis and, with sustained exposure, eventually lead to gastric cancer. Researchers have developed many in vivo gastric lesion models: the water immersion restraint (WIRE) stress model, the indomethacin-induced model and the ethanol-induced model using animals (1). The WIRE model has previously been used to observe various aspects affecting the formation of and recovery from gastric mucosal lesions, including sulphydryls, prostaglandins, growth factors and polyamines (2). WIRE stress-induced gastric lesions have also been used to study the roles of cell death and gastric acid secretion in ulcerogenesis (3).In general terms, gastric lesions are a disorder of the gastric blockade, which typically protects against cavernous problems caused by hydrogen ions and other toxic substances generated in the lumen (4). One main component of the gastric barrier is gastric microcirculation; a disturbance in gastric mucosal perfusion results in the formation of lesions and ulcers, such as those that present in animal models of ischemic gastric lesions (5). Gastric blood flow is classically controlled by signaling molecules, such as prostagland...

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The beneficial effect of the sap ofAcer monoin an animal with low-calcium diet-induced osteoporosis-like symptoms

Cited by 20 publications

References 38 publications

The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats

The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration

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