The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats

Yoo, Yeong‐Min; Jung, Eui‐Man; Kang, Ha‐Young; Choi, In‐Gyu; Choi, Kyung-Chul; Jeung, Eui‐Bae

doi:10.3892/ijmm.2011.724

Cited by 7 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study demonstrated that administration of isoquercitrin for five weeks inhibited hepatic inflammation and oxidative stress by suppressing transforming growth factor beta (TGF-β), signaling in the HFD-induced mice [37]. In addition, the sap of EAO reduced the hepatic oxidative stress and apoptosis in the alcohol-induced hepatic damage mouse model [45]. Therefore, our results suggest that EAO and isoquercitrin attenuate HFD-induced liver toxicity in HFD-and Aβ-induced mice.…”

Section: Discussionsupporting

confidence: 53%

The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model

2020

View full text Add to dashboard Cite

Obesity increases risk of Alzheimer’s Disease (AD). A high fat diet (HFD) can lead to amyloidosis and amyloid beta (Aβ) accumulation, which are hallmarks of AD. In this study, protective effects of the ethyl acetate fraction of Acer okamotoanum (EAO) and isoquercitrin were evaluated on obesity and amyloidosis in the HFD- and Aβ-induced mouse model. To induce obesity and AD by HFD and Aβ, mice were provided with HFD for 10 weeks and were intracerebroventricularly injected with Aβ25–35. For four weeks, 100 and 10 mg/kg/day of EAO and isoquercitrin, respectively, were administered orally. Administration of EAO and isoquercitrin significantly decreased body weight in HFD and Aβ-injected mice. Additionally, EAO- and isoquercitrin-administered groups attenuated abnormal adipokines release via a decrease in leptin and an increase in adiponectin levels compared with the control group. Furthermore, HFD and Aβ-injected mice had damaged liver tissues, but EAO- and isoquercitrin-administered groups attenuated liver damage. Moreover, administration of EAO and isoquercitrin groups down-regulated amyloidosis-related proteins in the brain such as β-secretase, presenilin (PS)-1 and PS-2 compared with HFD and Aβ-injected mice. This study indicated that EAO and isoquercitrin attenuated HFD and Aβ-induced obesity and amyloidosis, suggesting that they could be effective in preventing and treating both obesity and AD.

show abstract

Section: Discussionsupporting

confidence: 53%

The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model

2020

View full text Add to dashboard Cite

show abstract

“…The alcohol was decomposed into acetaldehyde by ADH and, subsequently, into acetate by ALDH, and then into carbon dioxide and water by the tricarboxylic acid cycle. Thus, the severely ethanol-induced liver injury might be associated with the activities of ADH and ALDH [ 39 ]. The CYP2E1 is one of important metabolic enzymes, which catalyzes the conversion of ethanol to acetaldehyde but, at the same time, also produces high amounts of ROS.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella radiata Polysaccharides on Alcohol-Induced Liver Injury

et al. 2018

View full text Add to dashboard Cite

This work was to examine the antioxidation in vitro and hepatoprotective effects of enzyme-extracted Oudemansiella radiata polysaccharides (En-OPS) on alcohol-induced liver damage in mice. The antioxidant activities were determined according to the scavenging effects of En-OPS on hydroxyl, superoxide, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, and the level of reducing power. En-OPS showed hepatoprotective activities on decreasing the serum levels of aspertate aminotransferase (AST), alamine aminotransferase (ALT), and alkaline phosphatase (ALP), as well as hepatic lipid levels of total cholesterol (TC) and triacylglycerols (TG). En-OPS treatment reversed the acute impairment induced by alcohol consumption, including reactive oxygen species (ROS) generation, malondialdehyde (MAD), and lipid peroxide (LPO) elevation; and superoxide dismutase (SOD), GSH peroxide (GSH-Px), catalase (CAT), and total antioxidant capacity (T-AOC) impairment. The En-OPS effectively ameliorated alcohol metabolism by activating alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), and reducing cytochrome P450 2E1 (CYP2E1) levels. Furthermore, the histopathological observations also displayed that En-OPS could alleviate liver damage. These results indicated that En-OPS could be suitable to be an ingredient of preventing alcoholic liver diseases (ALD). In addition, the preliminary structure characteristics of En-OPS were also analyzed by Fourier transform infrared (FT-IR) spectroscopy and a gas chromatography-flame ionization detector (GC-FID).

show abstract

“…Yoo and colleagues demonstrated that sap obtained from Acer pictum Thunb. (Acer okamotoanum) boosts alcohol metabolism in rats and protects against ethanol-induced apoptosis in hepatocytes [31]. In this study, we showed that raw tree saps from Betula pendula Roth., Alnus glutinosa Gaertn., and Carpinus betulus L. can stimulate metabolic activity in HepG2 model of human hepatocytes in vitro.…”

Section: Discussionmentioning

confidence: 74%

Metabolic activity of tree saps of different origin towards cultured human cells in the light of grade correspondence analysis and multiple regression modeling

et al. 2017

View full text Add to dashboard Cite

Tree saps are nourishing biological media commonly used for beverage and syrup production. Although the nutritional aspect of tree saps is widely acknowledged, the exact relationship between the sap composition, origin, and effect on the metabolic rate of human cells is still elusive. Thus, we collected saps from seven different tree species and conducted composition-activity analysis. Saps from trees of Betulaceae, but not from Salicaceae, Sapindaceae, nor Juglandaceae families, were increasing the metabolic rate of HepG2 cells, as measured using tetrazolium-based assay. Content of glucose, fructose, sucrose, chlorides, nitrates, sulphates, fumarates, malates, and succinates in sap samples varied across different tree species. Grade correspondence analysis clustered trees based on the saps' chemical footprint indicating its usability in chemotaxonomy. Multiple regression modeling showed that glucose and fumarate present in saps from silver birch (Betula pendula Roth.), black alder (Alnus glutinosa Gaertn.), and European hornbeam (Carpinus betulus L.) are positively affecting the metabolic activity of HepG2 cells.

show abstract

The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats

Cited by 7 publications

References 20 publications

The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model

The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model

Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella radiata Polysaccharides on Alcohol-Induced Liver Injury

Metabolic activity of tree saps of different origin towards cultured human cells in the light of grade correspondence analysis and multiple regression modeling

Contact Info

Product

Resources

About