The beneficial effect of oyster peptides and oyster powder on cyclophosphamide‐induced reproductive impairment in male rats: A comparative study

Abstract

In addition to being nutritional elements, proteins in food can also regulate the body's physiological functions, which is achieved via specific peptide sequences in the proteins (Chakrabarti, Guha, & Majumder, 2018). Therefore, although many bioactive peptides are stored in dietary proteins, the peptides remain inactive in the protein sequence and only have specific physiological functions after being released (Kitts & Weiler, 2003). Proteases from various sources can release biologically active peptides (Korhonen & Pihlanto, 2006), which are absorbed by the body via a different absorption route than the protein (Silk, Grimble, & Rees, 1985). Bioactive peptides can be absorbed directly from the intestine into the bloodstream, where they are highly active, exhibiting physiological effects in small amounts. The bioactive peptide activity is controlled by the composition and sequence of amino acids (Chakrabarti et al., 2018), and many peptides are known to reveal multifunctional properties

The Potential Protective Effect and Possible Mechanism of Peptides from Oyster (Crassostrea hongkongensis) Hydrolysate on Triptolide-Induced Testis Injury in Male Mice

“…The treatment of OPs restored the serum hormone level of mice to the normal, and reduced the disturbance of hormones on spermatogenesis in mice. Additionally, previous studies had found that oyster peptides improved the level of serum androgen induced by cyclophosphamide [ 45 ].…”

A Review of Bioactive Compounds in Oyster Shell and Tissues

“…Recent studies on OPs also revealed that they have collagen-restoring capabilities (i.e., anti-wrinkle properties) ( Hao et al, 2021 ). Further, OPs promote sexual reproduction by increasing the expression of key regulatory proteins and androgens, thereby increasing serum estrogen levels and improving male sexual function ( Li et al, 2020 ). For instance, GnRH-like peptides (Cg-GnRH-a and Cg-GnRH-G) isolated from the visceral ganglion of oysters regulate neurological and endocrine factors and provide nutrition and energy for reproduction ( Bigot et al, 2012 ).…”

A comprehensive review of oyster peptides: Preparation, characterisation and bioactivities

“…100 GnRH-like peptides were first isolated from 101 and have been proposed to exist in bivalve molluscs 102 Moreover, GnRH II has been found to regulate nutritional status and reproductive ability in vertebrates. 103 Oyster peptides have a demonstrated role in promoting reproduction by effectively increasing the expression of key regulatory proteins in the androgen production pathway, 4 which leads to higher serum testosterone levels and enhanced male sexual function. In a previous study with normal male mice fed with alkaline protease hydrolysate of oyster, mount latency (ML) decreased, whereas ejaculatory latency (EL), mount frequency (MF) and ejaculation frequency (EF) increased.…”