The Basics of Integra Dermal Regeneration Template and its Expanding Clinical Applications

Chang, Daniel K.; Louis, Mariam; Giménez, Alejandro; Reece, Edward M.

doi:10.1055/s-0039-1693401

Cited by 61 publications

(71 citation statements)

References 25 publications

(46 reference statements)

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“…The scaffold should be assembled according to its specific conformation and structure; in particular, pore sizes and their distribution are essential to providing a suitable matrix for effective cell migration and arrangement. These scaffolds represent a basis for revascularization, forming a proper microenvironment for cell migration and proliferation [ 67 ]. An example of a complete skin replacement is Apligraf, a bi-layered bioengineered skin substitute and the first engineered skin substitute approved by the US Food and Drug Administration (FDA) to promote the healing of ulcers that have failed standard wound care.…”

Section: Skin Regeneration Process and Skin Regeneration Therapiesmentioning

confidence: 99%

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

et al. 2020

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Skin wound healing shows an extraordinary cellular function mechanism, unique in nature and involving the interaction of several cells, growth factors and cytokines. Physiological wound healing restores tissue integrity, but in many cases the process is limited to wound repair. Ongoing studies aim to obtain more effective wound therapies with the intention of reducing inpatient costs, providing long-term relief and effective scar healing. The main goal of this comprehensive review is to focus on the progress in wound medication and how it has evolved over the years. The main complications related to the healing process and the clinical management of chronic wounds are described in the review. Moreover, advanced treatment strategies for skin regeneration and experimental techniques for cellular engineering and skin tissue engineering are addressed. Emerging skin regeneration techniques involving scaffolds activated with growth factors, bioactive molecules and genetically modified cells are exploited to overcome wound healing technology limitations and to implement personalized therapy design.

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Section: Skin Regeneration Process and Skin Regeneration Therapiesmentioning

confidence: 99%

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

et al. 2020

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“…Currently, INT is used for the reconstruction of several anatomical sites, ranging from the scalp to the lower extremity, for both post oncological and posttraumatic defects. 10 …”

Section: Discussionmentioning

confidence: 99%

Reconstruction of Full-thickness Soft Tissue Defects with Integra: Risk Factors and Treatment Algorithm

Scalise

Torresetti

Benedetto

2020

Plastic and Reconstructive Surgery - Global Open

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Background: Despite the fact that dermal substitutes are widely used in reconstructive surgery, there have been no studies focused on predictors of complications or delayed matrix take. We propose an algorithm for management of soft tissue reconstruction with Integra dermal matrix, based on our 5-year-long clinical experience. Methods: An estimated 111 patients who underwent Integra reconstruction of full-thickness soft tissue defects of different anatomical sites and etiology were enrolled, and dichotomized in two groups according to complications. Participants were further studied according to the wound healing strategy: healing by secondary intention, skin graft (STSG), and flap surgery. A regression analysis was conducted in the whole sample to identify possible predictors of complications. Results: No significant differences according to complications were observed. The between-group statistical analysis showed significant differences in age, comorbidities, defect area, diagnosis, and defect site. The regression analysis revealed that the timing of split-thickness skin graft (STSG) was not influenced by age, comorbidities, body mass index (BMI), defect area, site, wound etiology, and risk factors in the subjects who underwent a two-step reconstruction. Healing by secondary intention is recommended for small post-oncological defects of the head, especially in elderly and multimorbid patients. Variables that may interfere with dermal substitutes’ incorporation are independent of the timing of STSG placement; therefore, no predictors of complications or delayed matrix take were identified. Conclusions: Our findings showed that Integra can be used in a wide range of patients regardless of their general features, thus acting as a useful alternative to conventional reconstructive techniques in selected cases.

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“…These novel products are assembled according to their specific conformation and structure; in particular, pore sizes and their distribution are essential in providing a suitable matrix for effective cell migration and arrangement [54]. The novelty of these products represents a basis for revascularization, forming a proper microenvironment for cellular migration and proliferation [55]. For instance, Apligraf is the first bilayered living cellular skin substitute construct approved by the US Food and Drug Administration (FDA) containing keratinocytes and fibroblasts derived from donated human neonatal foreskin in bovine type 1 collagen matrix.…”

Section: Cells and Cellular Skin Substitutesmentioning

confidence: 99%

Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

2021

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Skin tissue engineering has made remarkable progress in wound healing treatment with the advent of newer fabrication strategies using natural/synthetic polymers and stem cells. Stem cell therapy is used to treat a wide range of injuries and degenerative diseases of the skin. Nevertheless, many related studies demonstrated modest improvement in organ functions due to the low survival rate of transplanted cells at the targeted injured area. Thus, incorporating stem cells into biomaterial offer niches to transplanted stem cells, enhancing their delivery and therapeutic effects. Currently, through the skin tissue engineering approach, many attempts have employed biomaterials as a platform to improve the engraftment of implanted cells and facilitate the function of exogenous cells by mimicking the tissue microenvironment. This review aims to identify the limitations of stem cell therapy in wound healing treatment and potentially highlight how the use of various biomaterials can enhance the therapeutic efficiency of stem cells in tissue regeneration post-implantation. Moreover, the review discusses the combined effects of stem cells and biomaterials in in vitro and in vivo settings followed by identifying the key factors contributing to the treatment outcomes. Apart from stem cells and biomaterials, the role of growth factors and other cellular substitutes used in effective wound healing treatment has been mentioned. In conclusion, the synergistic effect of biomaterials and stem cells provided significant effectiveness in therapeutic outcomes mainly in wound healing improvement.

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The Basics of Integra Dermal Regeneration Template and its Expanding Clinical Applications

Cited by 61 publications

References 25 publications

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

Reconstruction of Full-thickness Soft Tissue Defects with Integra: Risk Factors and Treatment Algorithm

Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

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