The Bacteriology of Chronic Rhinosinusitis With and Without Nasal Polyps

Niederfuhr, Andrea; Kirsche, Hanspeter; Riechelmann, Herbert; Wellinghausen, Nele

doi:10.1001/archoto.2008.531

Cited by 75 publications

(63 citation statements)

References 19 publications

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“…The pattern of bacterial isolates in our patients with CRS, either with or without polyposis, is similar to previous publications [7,10,11,12,13,14,15,16,17,21,22,23,24]. There was a high rate of aerobic pathogens, especially S. aureus and enteric bacteria, such as P. aeruginosa , and anaerobic species of Streptococcus and Proprionibacterium.…”

Section: Discussionsupporting

confidence: 89%

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Bacteriology of the Middle Meatus in Chronic Rhinosinusitis with and without Polyposis

Stern

Hadar²,

Nachalon³

et al. 2016

ORL

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There are only limited data in the literature, and none specifically from the Middle East, on the pathogenic bacteria in chronic rhinosinusitis (CRS) as opposed to healthy nasal cavities and their association with disease severity. The present study was conducted in the department of head and neck surgery of a tertiary medical center. Middle meatal swabs were taken preoperatively from patients with CRS with nasal polyposis (CRSwNP) (n = 60), CRS without nasal polyposis (CRSsNP) (n = 50), and control patients with septal deviation (n = 26) or no nasal abnormalities (n = 27). Culture findings were compared among the groups and correlated with CRS severity. Positive pathogenic culture rates were 78% in the CRSwNP group and 64% in the CRSsNP group. Twenty pathogenic bacterial species were identified; the most common was Staphylococcus aureus (27%). The most common Gram-negative isolate was Citrobacter spp. (17%). Gram-negative species were significantly more prevalent in the CRSwNP group than the others. Mean Lund-Mackay scores were 12.8 in the CRSwNP group and 6.9 in the CRSsNP group, and were unrelated to the culture findings. Positive culture rates were significantly higher in the septal deviation (54%) than the nasal healthy group (26%), although both values were significantly lower than in the CRS groups. In conclusion, patients with CRS have higher rates of bacterial isolates than patients without CRS. CRSwNP is associated with more Gram-negative bacteria than CRSsNP, regardless of disease severity. The relatively high positive culture rate in patients with septal deviation merits investigation.

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Section: Discussionsupporting

confidence: 89%

“…However, the bacteria isolated from patients with CRS with and without nasal polyposis [11,12,13,14,15] have been compared in only a few studies, conducted mainly in the United States, Europe, and the Far East. The characterization of sinus bacteriology in the Middle East has yet to be explored.…”

Section: Introductionmentioning

confidence: 99%

Bacteriology of the Middle Meatus in Chronic Rhinosinusitis with and without Polyposis

Stern

Hadar²,

Nachalon³

et al. 2016

ORL

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“…Many studies have examined the bacterial pathogens associated with chronic sinusitis, but the great majority of them included only a small, or indeterminate, number of patients with odontogenic infection (Kremer et al, 2001;Finegold et al, 2002;Aral et al, 2003;Niederfuhr et al, 2009), or did not test the antimicrobial susceptibility of these bacteria (Brook, 2005). While it is reported that the sinusitis of dental origin is polymicrobial and caused by bacteria from the oral cavity and from the upper airways (Mehra & Jeong, 2009), some aspects, such as the role of anaerobic bacteria in this infection, are not well studied and would need to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Bacteriological findings and antimicrobial resistance in odontogenic and non-odontogenic chronic maxillary sinusitis

Puglisi

Privitera

Maiolino

et al. 2011

Journal of Medical Microbiology

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The main objectives of this study were to estimate the frequency of chronic maxillary sinusitis of dental origin, and to evaluate the microbiology of odontogenic and non-odontogenic chronic maxillary sinusitis. Aspirates from 59 patients with chronic maxillary sinusitis (47 non-odontogenic, 12 odontogenic), collected during a 3-year period, were microbiologically processed for aerobic and anaerobic bacteria. Moreover, antimicrobial susceptibility was evaluated in the isolated bacteria. In this study, 20 % of chronic maxillary sinusitis cases were associated with a dental origin, and sinus lift procedures were the main aetiological factor. Our microbiological findings showed that all specimens from chronic maxillary sinusitis were polymicrobial. Sixty aerobes and 75 anaerobes were recovered from the 47 cases of non-odontogenic sinusitis (2.9 bacteria per specimen); 15 aerobes and 25 anaerobes were isolated from the 12 patients with odontogenic sinusitis (3.3 bacteria per specimen). The predominant aerobes were Staphylococcus aureus (27) and Streptococcus pneumoniae (16), while the more frequent anaerobes were Peptostreptococcus species (31) and Prevotella species (30). Haemophilus influenzae and Moraxella catarrhalis were absent in sinusitis associated with a dental origin. Overall, 22 % of Staphylococcus aureus isolates were oxacillin-resistant, and 75 % of Streptococcus pneumoniae isolates were penicillin-resistant and/or erythromycin-resistant; 21 % of anaerobic Gram-positive bacteria were penicillin-resistant, and 44 % of anaerobic Gram-negative bacteria were blactamase-positive. Vancomycin and quinopristin-dalfopristin had the highest in vitro activity against Staphylococcus aureus and Streptococcus species, respectively; amoxicillin-clavulanate and cefotaxime showed the highest in vitro activity against aerobic Gram-negative bacteria; and moxifloxacin, metronidazole and clindamycin were the most active against anaerobic bacteria.

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“…Результаты исследований свидетельствуют о том, что бактериальная флора околоносовых пазух здо-ровых добровольцев и пациентов с ХР во многом схожа [23]. Тем не менее у пациентов с ХР при микробиологиче-ском исследовании микрофлоры околоносовых пазух отмечаются повышенная концентрация микроорганиз-мов, склонных к образованию биопленок, более частое высевание Staphylococcus aureus, включая метициллинре-зистентные штаммы, особенно у пациентов с сопутствую-щим диабетом, а также наличие анаэробных полирези-стентных микроорганизмов в сочетании с грамотрица-тельной флорой [24].…”

Section: хронический риносинусит (хр)unclassified

Antibacterial Therapy for Acute and Chronic Diseases of the Upper Respiratory Tract in Adults

Дербенева¹

2017

Medicinskij sovet

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В статье представлены наиболее часто встречающиеся заболевания верхних дыхательных путей у взрослых, дифферен-циально-диагностические критерии острой респираторной вирусной инфекции, острого тонзиллофарингита, острого и хронического риносинусита. Обсуждаются необходимость, сроки назначения антибактериальной терапии, а также группы антибиотиков и их дозировки при этих заболеваниях.

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The Bacteriology of Chronic Rhinosinusitis With and Without Nasal Polyps

Cited by 75 publications

References 19 publications

Bacteriology of the Middle Meatus in Chronic Rhinosinusitis with and without Polyposis

Bacteriology of the Middle Meatus in Chronic Rhinosinusitis with and without Polyposis

Bacteriological findings and antimicrobial resistance in odontogenic and non-odontogenic chronic maxillary sinusitis

Antibacterial Therapy for Acute and Chronic Diseases of the Upper Respiratory Tract in Adults

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