The association of uric acid with leukoaraiosis

Abstract

ObjectiveTo explore the possible correlation between uric acid levels and leukoaraiosis (LA).MethodsThis cross-sectional study enrolled patients who presented with some neurological discomfort (e.g. dizziness, headache, mild cognitive impairment). Potential demographic and clinical risk factors associated with LA, including sex, age, hypertension, diabetes mellitus, smoking, alcohol consumption, dyslipidaemia, plasma fibrinogen, D-dimer, uric acid, and homocysteine, were investigated using univariate and multivariate logistic regression analyses.ResultsA total of 268 patients were enrolled in the study and divided into the LA group (n = 164) and the non-LA group (n = 104). Compared with the non-LA group, uric acid was significantly higher in the LA group (mean ± SD: 356.49 ± 121.85 µmol/l versus 289.96 ± 102.98 µmol/l). Multivariate logistic regression analyses showed that uric acid was an independent risk factor for LA (odds ratio 1.285; 95% confidence interval 1.062, 1.556).ConclusionHyperuricaemia was an independent risk factor for leukoaraiosis in Chinese patients.

Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients

“…Therefore, an automated WMLs volumetric/quantitative analysis is suggested to be applied in the epidemiology study of LA in future. In addition, the association analysis of several recently reported risk factors, such as C-reactive protein, uric acid, thyroid function and vitamin B12, obesity index-body mass, and working and living conditions, [ 43 – 45 ] with the risk of LA were not conducted in this study since these parameters were not available for all of subjects. The last but not the least is the limitation that both the percent of subjects with stroke among this study cohort and the relationship of stroke and LA could not be assessed because the information is inaccessible for a large portion of subjects.…”

Evaluation of serum uric levels in migraine

“…Lifelong exposure to dietary, environmental, physiologic, behavioral, and pharmacological factors exposes brain tissue to oxidative injury. As a result, oxidative stress is important for many neurologic disorders including migraine [10][11][12][13]. Some studies have reported a significant correlation between oxidative changes and migraine, while some have not found a significant correlation.…”

“…Migraine threshold is linked to a sensitive balance between oxidative phosphorylation occurring in mitochondria and stimulation and inhibition in the central nervous system [8,16]. The end-product of endogenous and exogenous purine catabolism of uric acid (UA) protects erythrocytes from lipid peroxidation and hemoglobin from peroxide oxidation and at normal levels scavenges toxic reactants, showing endogenous antioxidant activity [11,13,[17][18][19][20][21].…”

Decreased serum uric acid in patients with traumatic brain injury or after cerebral tumor surgery

“…12 UA has a strong endogenous antioxidant effect in some oxidative stress-induced neurodegenerative diseases and is also involved in numerous disorders, including cardiovascular disease, obesity, diabetes, leukoaraiosis, as well as inflammation. 2,3,[13][14][15][16] Although UA may exert an important function in protecting neurons from inflammatory injuries, it is still not clear what the role of UA is in brain injury patients. Some studies have found that a low GCS was related to a low UA level in patients with TBI, suggesting that UA may have some function in the recovery from consciousness.…”