Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients

Lin, Qing; Huang, Wenyan; Ma, Qin; Lu, Cong-Xia; Tong, Suijun; Ye, Jin-Hu; Lin, Hongyang; Gu, Lianzhi; Yi, Ke-Hui; Cai, Lun; Tzeng, Chi-Meng

doi:10.1097/md.0000000000007682

Cited by 56 publications

(66 citation statements)

References 43 publications

(42 reference statements)

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“…Of note, all women included in the present study were in menopausal status, therefore, no between-group imbalance in terms of hormonal status can be hypothesized as an underlying confounder. Another hospital-based cross-sectional study observed that female gender was associated with leukoaraiosis even if no quantitative analysis of WMHs was performed [32]. While the biological processes underlying this phenomenon are incompletely understood, it is currently accepted that females have a different susceptibility compared with males to neurodegeneration and neuroinflammatory conditions [33].…”

Section: Discussionmentioning

confidence: 99%

Progression of brain white matter hyperintensities in asymptomatic patients with carotid atherosclerotic plaques and no indication for revascularization

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Progression of brain white matter hyperintensities in asymptomatic patients with carotid atherosclerotic plaques and no indication for revascularization

et al. 2019

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“…Lin et. al reported both smoking and total HCY levels were shown to be risk factors for LA occurrence (15). Wang et al observed an independent association between Hcy level and severity of the CMBs (16).…”

Section: Discussionmentioning

confidence: 98%

H-type Hypertension is a risk factor for Cerebral Small Vessel Disease: a retrospective study

Cai¹,

Fang

et al. 2019

Preprint

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Background: The correlation between H-type hypertension and cerebral small-vessel diseases (CSVD) remains uncertain. The present study was designed to explore the possible relationship between H-type hypertension and CSVD spectrum and total burden. Methods: We included 329 patients in the present study and divided them into four groups: H-type hypertension group, the isolated hypertension group, the isolated hyperhomocysteinemia (HHcy) group and the control group. Clinical variables of interest and the MR examination sequences were obtained. We count the presence of each CSVD feature and rated the total burden of CSVD on an ordinal scale from 0 to 4 according to a recent described score rule. Results: The results showed that H-type hypertension was associated with the presence of CMB and the severity of WMH and PVS. CSVD total burden was significantly related to age (OR: 1.059, 95% CI: 1.037-1.082), systolic pressure (OR: 1.122, 95% CI: 1.007-1.136), triglycerides (OR: 1.386, 95% CI: 1.037-1.854), isolated HHcy (OR: 4.154, 95% CI 1.836–9.401) and H-type hypertension (OR: 5.028, 95% CI 2.323-10.883). And we further observed hypertension and HHcy had a synergistic effect on CSVD total burden (OR: 2.776, 95% CI 1.564-4.927). Conclusions: H-type hypertension may act as an independent risk factor of CSVD and cause increased susceptibility to CSVD total burden and CSVD spectrum, which deserved further prevention measures.

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“…Another study found that, in Japanese patients, elevated Hcy level is independently associated with leukoaraiosis, but not with the incidence of microbleeds [15]. Lin et al reported both smoking and total HCY levels were shown to be risk factors for lacunes occurrence [16]. Wang et al observed an independent association between Hcy level and severity of the CMBs [17].…”

Section: Discussionmentioning

confidence: 99%

H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease

Tan

Liu

Diao

et al. 2020

BioMed Research International

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Background. The correlation between H-type hypertension and cerebral small-vessel diseases (CSVD) remains uncertain. Objective. The present study was designed to explore the possible relationship between H-type hypertension and CSVD spectrum and total burden. Method. We included 329 patients in the present study and divided them into four groups: the H-type hypertension group, isolated hypertension group, isolated hyperhomocysteinemia (HHcy) group, and control group. Clinical variables of interest and the MR examination sequences were obtained. We counted the presence of each CSVD feature and rated the total burden of CSVD on an ordinal scale from 0 to 4 according to a recent described score rule. Result. The results showed that H-type hypertension was associated with the presence of cerebral microbleeds (CMBs), and the severity of white-matter hyperintensities (WMHs) and peripheral vascular space (PVS). CSVD total burden was significantly related to age (OR: 1.059, 95% CI: 1.037–1.082), systolic pressure (OR: 1.122, 95% CI: 1.007–1.136), triglycerides (OR: 1.386, 95% CI: 1.037–1.854), isolated HHcy (OR: 4.154, 95% CI 1.836–9.401), and H-type hypertension (OR: 5.028, 95% CI: 2.323–10.883). Also, we further observed hypertension and HHcy had a synergistic effect on CSVD total burden (OR: 2.776, 95% CI: 1.564–4.927). Conclusion. H-type hypertension was associated with CSVD total burden and CSVD spectrum, which deserves further prevention measures. Furthermore, hypertension and HHcy had a synergistic effect on CSVD total burden.

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Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients

Abstract: Supplemental Digital Content is available in the text

Cited by 56 publications

References 43 publications

Progression of brain white matter hyperintensities in asymptomatic patients with carotid atherosclerotic plaques and no indication for revascularization

Progression of brain white matter hyperintensities in asymptomatic patients with carotid atherosclerotic plaques and no indication for revascularization

H-type Hypertension is a risk factor for Cerebral Small Vessel Disease: a retrospective study

H-Type Hypertension Is a Risk Factor for Cerebral Small-Vessel Disease

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