Evaluation of serum uric levels in migraine

Yazar, Tamer; Yazar, Hülya Olgun; Aygün, Ali; Karabacak, Volkan; Altunkaynak, Yavuz; Kırbaş, Dursun

doi:10.1007/s10072-020-04598-w

Cited by 7 publications

(8 citation statements)

References 37 publications

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“…UA is the final product of purine metabolism ( 25 ) and can scavenge reactive oxygen species in the body ( 26 ). Yazar et al reported that UA levels were lower in patients with migraine ( 27 ), which was consistent with our findings. UA acts as an endogenous antioxidant that can reduce oxidative damage and inhibits inflammatory responses, which reduces the permeability of the blood-brain barrier (BBB) and exerts neuroprotective effects ( 28 ).…”

Section: Discussionsupporting

confidence: 93%

Evaluation of simple antioxidant blood parameters in patients with migraine

Yang

Xu²,

Geng³

et al. 2022

Front. Neurol.

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BackgroundThe study aims to investigate the role of serum albumin (ALB) and creatinine (CRE), bilirubin (BIL), and uric acid (UA) as major intravascular antioxidants in migraine.MethodsWe enrolled 148 patients with migraine and 150 age- and sex-matched healthy controls. The serum levels of ALB, TBIL, CRE, and UA were measured in patients with migraine of different subtypes. The risk of migraine was assessed by multiple stepwise logistic regression analysis.ResultsThe serum levels of ALB, total BIL (TBIL), CRE, and UA were significantly lower in the migraine group than in the HC group (p < 0.05). The ALB and UA levels were lower during migraine attack periods (p < 0.05). There were no statistically significant differences observed in serum ALB, TBIL, CRE, and UA levels between aura/without aura and episodic/chronic migraine subtypes (p > 0.05). The multiple stepwise logistic regression revealed that ALB [odds ratio (OR) 0.79, 95% confidence interval (CI) 0.69–0.89, p < 0.001], TBIL (OR 0.61, 95% CI 0.5–0.75, p < 0.001), and UA (OR 0.97, 95% CI 0.96–0.99, p = 0.014) were independently associated with migraine. In addition, the serum levels of ALB, TBIL, and UA were significantly lower in the migraine group when compared by sex.ConclusionThe serum levels of UA, TBIL, ALB, and CRE were lower in the patients with migraine, indicating a lower antioxidant status. In addition, ALB, TBIL, and UA were independently related to migraine. These results could provide insights into the possible role of oxidative stress in the pathogenesis of migraine.

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Section: Discussionsupporting

confidence: 93%

Evaluation of simple antioxidant blood parameters in patients with migraine

Yang

Xu²,

Geng³

et al. 2022

Front. Neurol.

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“…In addition, the contradiction of anti-oxidant effects and pro-oxidant effects might be due to the dose effect of serum urate (13). A previous study showed that a lower serum urate level was found in migraine, which was not influenced by the subtypes of migraine (14). However, another study found that serum urate in migraine might be more than control group, which had not shown the results of statistical hypothesis testing (15).…”

Section: Introductionmentioning

confidence: 96%

An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES

et al. 2022

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BackgroundMigraine is a common neurological disease and an important cause of disability worldwide. Serum urate is the end product of purine metabolism in Homo sapiens and other hominoids. Previous studies about the serum urate level in migraine were contradictory. Hence, we present a cross-section study to clarify the association between serum urate and migraine and explore the dose effect of serum urate on migraine.Materials and MethodsThe data for this cross-section study were acquired from the National Health and Nutrition Examination Survey (NHANES). A diagnosis of migraine was made through patient the self-reported and prescription medication. For data analysis, the weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the two-piecewise linear regression model were utilized for data analysis. All data analysis was conducted on Empower software.ResultsTotally, 18,637 participants were enrolled in this study, of which 208 were migraineurs. The rest were set as control. There existed a statistically significant difference in mean age (p = 0.0389), gender (p< 0.0001), race (p< 0.0001), data release cycle (p = 0.048), drug usage, blood albumin (p< 0.0001), blood total protein (p< 0.0001), hemoglobin (p< 0.0001), serum iron (p< 0.0001), and serum urate (p< 0.0001) between the two groups. According to logistic regression models, there existed no consistent linear relationship between serum urate and migraine before (model 1: odd ratio (OR) = 0.83, p = 0.0004) or after adjusting for confounders (model 2: OR = 0.96, p = 0.5198; model 3: OR = 0.84, p = 0.0184). However, smooth curve fittings found an exponential curve relationship between serum urate and migraine. Furthermore, when serum urate was more than 7.8 mg/dl, higher serum urate was correlated with higher migraine occurrence (model 1: OR = 1.54, p = 0.0022; model 2: OR = 1.51, p = 0.0050; model 3: OR = 1.77, p = 0.0348). Besides, 8 out of the 208 migraineurs had a serum urate higher than 7.8 mg/dl.ConclusionsIn conclusion, there existed an exponential curve relationship between serum urate and migraine, with an infliction point of 7.8 mg/dl. When serum urate was more than 7.8 mg/dl, increased serum urate was correlated with higher migraine occurrence.

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“…These values were well within the normal range (male 3.4-7 mg/dl, female 2.4-5.7 mg/dl); and there was also no statistically significant difference in uric acid levels in either gender. Many other studies have also reported non-significant difference in serum uric acid levels between migraine cases and healthy controls [13,16]. We could not find any study which had compared uric acid levels between male and female migraine patients.…”

Section: Discussionmentioning

confidence: 60%

“…Many others studies have also reported similar mean age of migraine patients [13,14]. Most of the studies have earlier proved that migraine is common in female patients [14,15].…”

Section: Discussionmentioning

confidence: 65%

A Study to Correlate the Serum Uric Acid Levels With the Duration and Severity of Migraine

Khamesra

PANCHAL

2022

Asian J Pharm Clin Res

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Objectives: The objectives of the study were to assess the serum levels of uric acid in patients of migraine and to correlate the levels of uric acid with duration and severity of migraine. Methods: This observational study was conducted in patients with complaint of headache, due to migraine who attended neurology and general medicine out patients department of tertiary care teaching hospital of Udaipur, Rajasthan. Uric acid levels were compared between both the genders with respect to age group, frequency of attack, and duration of migraine. Uric acid levels were also correlated with different parameters. Results: A total of 500 patients were evaluated during the study period of 2 years. Mean uric acid in male patients was 5.02±1.40 mg/dl, and in females it was 4.99±1.39 mg/dl. Uric acid levels in male and female patients were found non-significant across all age groups, with duration of migraine and frequency of migraine attack (p>0.05). There was a significant correlation between uric acid levels and migraine severity in present study (p˂0.05), but there was no correlation with age, duration of migraine, and frequency of migraine attacks per month (p>0.05). Conclusion: The study concluded that uric acid levels are within normal range in all age group as well as either of gender in patients of migraine. Hence, there is no relation between uric acid and duration and frequency of migraine but positive correlation with severity of migraine.

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Evaluation of serum uric levels in migraine

Cited by 7 publications

References 37 publications

Evaluation of simple antioxidant blood parameters in patients with migraine

Evaluation of simple antioxidant blood parameters in patients with migraine

An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES

A Study to Correlate the Serum Uric Acid Levels With the Duration and Severity of Migraine

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