The association of quantitative insulin sensitivity indices (HOMA-IR and QUICKI) with anthropometric 
and cardiometabolic indicators in adolescents

Mirzaalian, Yaser; Nourian, Mozhgan; Doaei, Saeid; Hatami, Mahshid; Hassanzadeh, Akbar; Askari, Gholamreza; Farahi, Raheleh

doi:10.5114/amsad.2019.84411

Cited by 18 publications

(8 citation statements)

References 28 publications

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“…The HOMA-IR index indicates insulin resistance based on the amount of fasting plasma glucose and insulin. Several studies suggest that QUICKI can be a good alternative for HOMA-IR [ 42 ]. Moreover, a recent study showed a significant correlation between anthropometric and cardiometabolic parameters with both HOMA-IR and QUICKI [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Shedding “LIGHT” on the Link between Bone and Fat in Obese Children and Adolescents

Brunetti

Faienza

Piacente

et al. 2020

IJMS

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Obesity may affect bone health, but literature reports are contradictory about the correlation of body mass index (BMI) and bone markers. LIGHT, one of the immunostimulatory cytokines regulating the homeostasis of bone and adipose tissue, could be involved in obesity. The study involved 111 obese subjects (12.21 ± 3.71 years) and 45 controls. Patients underwent the evaluation of bone status by quantitative ultrasonography (QUS). LIGHT amounts were evaluated in sera by ELISA, whereas its expression on peripheral blood cells was evaluated by flow cytometry. Osteoclastogenesis was performed by culturing peripheral blood mononuclear cells (PBMCs) with or without anti-LIGHT antibodies. Obese patients showed significant high BMI-standard deviation score (SDS), weight-SDS, and Homeostatic model assessment for insulin resistance (HOMA-IR) that negatively correlated with the reduced Amplitude Dependent Speed of Sound (AD-SoS)-Z-score and Bone Transmission Time (BTT-Z)-score. They displayed significantly higher serum levels of LIGHT compared with controls (497.30 ± 363.45 pg/mL vs. 186.06 ± 101.41 pg/mL, p < 0.001). LIGHT expression on monocytes, CD3+-T-cells, and neutrophils was also higher in obese patients than in the controls. Finally, in PBMC cultures, the addition of anti-LIGHT antibodies induced a significant osteoclastogenesis inhibition. Our study highlighted the high serum levels of LIGHT in obese children and adolescents, and its relationship with both the grade of obesity and bone impairment.

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Section: Discussionmentioning

confidence: 99%

Shedding “LIGHT” on the Link between Bone and Fat in Obese Children and Adolescents

Brunetti

Faienza

Piacente

et al. 2020

IJMS

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“…All these mechanisms result IR in parallel to an increase in BMI and WC. Significant correlations between BMI and WC with IR measured by HOMA, QUICKI and MCA indices have been reported previously to a limited extent [ 15 , 29 , 30 ], however the selected indices; HOMA, QUICKI and MCA were not reported collectively in a single study on newly diagnosed T2DM patients. Hence, this is the first report of correlation analysis of the selected clinical parameters of BMI, WC, age and TG/HDL-C ratio with indices of HOMA, QUICKI and MCA on newly diagnosed patients with T2DM.…”

Section: Discussionmentioning

confidence: 97%

Value of simple clinical parameters to predict insulin resistance among newly diagnosed patients with type 2 diabetes in limited resource settings

et al. 2021

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Background Insulin resistance (IR) has been considered as a therapeutic target in the management of type 2 diabetes mellitus (T2DM). Readily available, simple and low cost measures to identify individuals with IR is of utmost importance for clinicians to plan optimal management strategies. Research on the associations between surrogate markers of IR and routine clinical and lipid parameters have not been carried out in Sri Lanka, a developing country with rising burden of T2DM with inadequate resources. Therefore, we aimed to study the utility of readily available clinical parameters such as age, body mass index (BMI), waist circumference (WC) and triglyceride to high density lipoprotein cholesterol ratio (TG/HDL-C) in the fasting lipid profile in predicting IR in a cohort of patients with newly diagnosed T2DM in Sri Lanka. Methods and findings We conducted a community based cross sectional study involving of 147 patients (age 30–60 years) with newly diagnosed T2DM in a suburban locality in Galle district, Sri Lanka. Data on age, BMI, WC, fasting plasma glucose (FPG) concentration, fasting insulin concentration and serum lipid profile were collected from each subject. The indirect IR indices namely homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI) and McAuley index (MCA) were estimated. Both clinical and biochemical parameters across the lowest and the highest fasting insulin quartiles were compared using independent sample t-test. Linear correlation analysis was performed to assess the correlation between selected clinical parameters and indirect IR indices. The area under the receiver operating characteristic (ROC) curve was obtained to calculate optimal cut-off values for the clinical markers to differentiate IR. BMI (p<0.001) and WC (p = 0.01) were significantly increased whereas age (p = 0.06) was decreased and TG/HDL-C (p = 0.28) was increased across the insulin quartiles. BMI and WC were significantly correlated (p<0.05) with HOMA, QUICKI and MCA. Out of the clinical parameters, age showed a borderline significant correlation with QUICKI and TG/HDL-C showed a significant correlation only with MCA. The area under ROC of BMI was 0.728 (95% CI 0.648–0.809; p<0.001) and for WC, it was 0.646 (95% CI 0.559–0.734; p = 0.003). The optimized cut-off value for BMI and WC were 24.91 kg/m2 and 81.5 cm respectively to differentiate the patients with IR or ID. Study limitations include small sample size due to recruitment of patients only from a limited geographical locality of the country and not totally excluding of the possibility of inclusion of some patients with slowly progressive type 1 DM or Latent onset diabetes of adulthood from the study population. Conclusions The results revealed that there was a significant positive correlation between BMI, WC and HOMA while a significant negative correlation with QUICKI and MCA among the cohort of patients with newly diagnosed T2DM. The cut-off values of BMI and WC as 24.91 kg/m2 and 81.5 cm respectively could be used as simple clinical parameters to identify IR in newly diagnosed patients with T2DM. Our results could be beneficial in rational decision making in the management of newly diagnosed patients with T2DM in limited resource settings.

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“…Furthermore, high levels of triglycerides and leptin levels were presented in preeclampsia-exposed children who measured low on the Quantitative Insulin Sensitivity Check Index (QUICKI), which is an assessment used to calculate the insulin resistance degree and the secretory capacity of the pancreatic beta cells [ 195 ]. Low levels of QUICKI indicate highly insulin resistance, which is associated with obesity risk and cardiovascular diseases [ 196 ].…”

Section: Omics Technologies Applied To the Precision Nutrition In Prementioning

confidence: 99%

Personalized Nutrition Approach in Pregnancy and Early Life to Tackle Childhood and Adult Non-Communicable Diseases

Alabduljabbar

Zaidan

Lakshmanan

et al. 2021

Life

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The development of childhood and adult non-communicable diseases (NCD) is associated with environmental factors, starting from intrauterine life. A new theory finds the roots of epigenetic programming in parental gametogenesis, continuing during embryo development, fetal life, and finally in post-natal life. Maternal health status and poor nutrition are widely recognized as implications in the onset of childhood and adult diseases. Early nutrition, particularly breastfeeding, also plays a primary role in affecting the health status of an individual later in life. A poor maternal diet during pregnancy and lack of breastfeeding can cause a nutrient deficiency that affects the gut microbiota, and acts as a cofactor for many pathways, impacting the epigenetic controls and transcription of genes involved in the metabolism, angiogenesis, and other pathways, leading to NCDs in adult life. Both maternal and fetal genetic backgrounds also affect nutrient adsorption and functioning at the cellular level. This review discusses the most recent evidence on maternal nutrition and breastfeeding in the development of NCD, the potentiality of the omics technologies in uncovering the molecular mechanisms underlying it, with the future prospective of applying a personalized nutrition approach to prevent and treat NCD from the beginning of fetal life.

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The association of quantitative insulin sensitivity indices (HOMA-IR and QUICKI) with anthropometric and cardiometabolic indicators in adolescents

Cited by 18 publications

References 28 publications

Shedding “LIGHT” on the Link between Bone and Fat in Obese Children and Adolescents

Shedding “LIGHT” on the Link between Bone and Fat in Obese Children and Adolescents

Value of simple clinical parameters to predict insulin resistance among newly diagnosed patients with type 2 diabetes in limited resource settings

Personalized Nutrition Approach in Pregnancy and Early Life to Tackle Childhood and Adult Non-Communicable Diseases

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