The association of oxytocin with major depressive disorder: role of confounding effects of antidepressants

Xie, Shiyi; Hu, Yan; Fang, Li; Chen, Shijia; Botchway, Benson O. A.; Tan, Xiaoning; Fang, Marong; Hu, Zhiying

doi:10.1515/revneuro-2020-0128

Cited by 10 publications

(8 citation statements)

References 224 publications

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“…In general, the anti-depressive effect of OT is believed due to its regulating neuronal activity, influencing neuroplasticity and regeneration, altering neurotransmitter release, down-regulating hypothalamic-pituitary-adrenal (HPA) axis, anti-inflammation, antioxidation, and genetic effects ( Xie et al, 2022 ). As shown in studies on rats, excessive increase in glucocorticoids in chronic stress causes atrophy of the hippocampus ( Warfvinge et al, 2020 ), while central OT can activate GABA A -receptors in the PVN and thus inhibit acute restraint stress-induced corticotrophin-releasing hormone mRNA expression ( Bulbul et al, 2011 ) and the toxic effects of glucocorticoids ( Matsushita et al, 2019 ).…”

Section: Higher Brain Functionsmentioning

confidence: 99%

“…(1) (Cuneo et al, 2021;Jahangard et al, 2020;Meixner et al, 2019); (2) (Jung et al, 2021;Liu et al, 2021a;Maier et al, 2019;Wang et al, 2021b); (3) (Runyan et al, 2021;Sabe et al, 2021; (4) (John & Jaeggi, 2021;Shishido et al, 2021;Yoshihara et al, 2018;Yuan et al, 2019); (5) (Reichova et al, 2021;Tyzio et al, 2014); (6) (Francesconi et al, 2021;Huang et al, 2021;Jimenez et al, 2015;Li et al, 2020; (7) (Feifel et al, 2012;Guastella et al, 2008;Latt et al, 2018;Plasencia et al, 2019;Tse et al, 2018); (8) (Bertoni et al, 2021;Hu et al, 2015;Larrazolo-Lopez et al, 2008); (9) (Kreutzmann & Fendt, 2021;Takahashi et al, 2020 (10) (Fisher et al, 2021;La Fratta et al, 2021;Torres et al, 2022;Warrener et al, 2021); (11) (Borroto-Escuela et al, 2021;Matsushita et al, 2019;Xie et al, 2022;Yoshida et al, 2009); (12) …”

Section: Pro-social Behaviormentioning

confidence: 99%

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Neural Functions of Hypothalamic Oxytocin and its Regulation

Wang

Liu

et al. 2022

ASN Neuro

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Oxytocin (OT), a nonapeptide, has a variety of functions. Despite extensive studies on OT over past decades, our understanding of its neural functions and their regulation remains incomplete. OT is mainly produced in OT neurons in the supraoptic nucleus (SON), paraventricular nucleus (PVN) and accessory nuclei between the SON and PVN. OT exerts neuromodulatory effects in the brain and spinal cord. While magnocellular OT neurons in the SON and PVN mainly innervate the pituitary and forebrain regions, and parvocellular OT neurons in the PVN innervate brainstem and spinal cord, the two sets of OT neurons have close interactions histologically and functionally. OT expression occurs at early life to promote mental and physical development, while its subsequent decrease in expression in later life stage accompanies aging and diseases. Adaptive changes in this OT system, however, take place under different conditions and upon the maturation of OT release machinery. OT can modulate social recognition and behaviors, learning and memory, emotion, reward, and other higher brain functions. OT also regulates eating and drinking, sleep and wakefulness, nociception and analgesia, sexual behavior, parturition, lactation and other instinctive behaviors. OT regulates the autonomic nervous system, and somatic and specialized senses. Notably, OT can have different modulatory effects on the same function under different conditions. Such divergence may derive from different neural connections, OT receptor gene dimorphism and methylation, and complex interactions with other hormones. In this review, brain functions of OT and their underlying neural mechanisms as well as the perspectives of their clinical usage are presented.

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Section: Higher Brain Functionsmentioning

confidence: 99%

Section: Pro-social Behaviormentioning

confidence: 99%

Neural Functions of Hypothalamic Oxytocin and its Regulation

Wang

Liu

et al. 2022

ASN Neuro

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“…Numerous animal and human research have implicated OT secretion problems in multiple mental illnesses, including depression, anxiety, schizophrenia, and autism spectrum disorders [36]. The antidepressant effects of OT are thought to be due to its modulation of neuronal activity, in uence on neuroplasticity and regeneration, alteration of neurotransmitter release, and downregulation of hypothalamic-pituitary-adrenal (HPA) axis, antiin ammatory, antioxidant and genetic effects [37].…”

Section: Discussionmentioning

confidence: 99%

Functional modular networks identify the pivotal genes associated with morphine addiction and potential drug therapies

Jiang

Wei

Xie

2022

Preprint

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Background Chronic morphine usage induces lasting molecular and microcellular adaptations in distinct brain areas, resulting in addiction-related behavioural abnormalities, drug-seeking, and relapse. Nonetheless, the mechanisms of action of the genes responsible for morphine addiction have not been exhaustively studied. Methods We obtained morphine addiction-related datasets from the GEO database and screened for differential genes (DEGs) by GEO2R analysis.WGCNA functional modularity constructs were analyzed for genes associated with clinical traits. Venn diagrams were filtered for intersecting common differential genes (CDEGs). Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for functional annotation. Protein-protein interaction network (PPI) and CytoHubba were used to screen for hub genes (Hub). Potential treatments for morphine addiction were figured out with the help of an online database. Results 65 common differential genes linked to morphine addiction were identified, and functional enrichment analysis showed that they were primarily involved in ion channel activity, protein transport, the oxytocin signalling pathway, neuroactive ligand-receptor interactions, and other signalling pathways. Based on the PPI network, ten Hub genes (Chn2, Olig2, Ugt8a, Cacnb2, Timp3, Fkbp5, Zbtb16, Tsc22d3, Isl1, and Slc2a1) were checked. In the data set GSE7762, all of the AUC values for the Hub gene ROC curves were greater than 0.8. We also used the DGIdb database to look for eight small-molecule drugs that might be useful for treating morphine addiction. Conclusions The Hub genes are crucial genes associated with morphine addiction in the mouse striatum, and morphine addiction is highly correlated with these genes. The oxytocin signalling pathway may play a vital role in developing morphine addiction.

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“…One such biological factor is the peptide hormone, oxytocin. Oxytocin is thought to affect and be affected by depressive symptoms through various mechanisms including attenuation of cortisol release in response to stress, attenuation of proinflammatory cytokines, and modulation of brain regions involved in depression (24)(25)(26)(27)(28). Previous research has yielded variable results regarding the directionality of the relationship between oxytocin levels and depression.…”

Section: Introductionmentioning

confidence: 99%

“…This ambiguity has been captured in a recent qualitative review ( 28 ) and a meta-analysis comparing basal endogenous oxytocin concentrations in patients with depression versus healthy controls ( 36 ). Possible reasons for equivocal findings include sample differences in age, sex ( 27 , 37 ), and the clinical severity of depressive symptoms. In addition, heterogenous findings may be the result of sampling only one or a few time points, which provides only a brief snapshot of the dynamic oxytocin system.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV

et al. 2022

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ObjectiveDepression is common in people with HIV (PWH), yet little is known about the mechanisms contributing to depressive symptoms in PWH. Previous research across a range of populations has suggested a relationship between the neuropeptide oxytocin and depressive symptoms, with variable directionality. This article investigated the association between peripheral oxytocin levels and depressive symptoms in PWH.MethodsUnextracted oxytocin serum concentrations were assayed in 79 PWH (44% female, mean age = 34.35 [8.5], mean body mass index = 25.69 [5.46], mean CD4 = 516.60 [271.15]) who also completed the Center for Epidemiologic Studies Depression Scale (CES-D). CES-D items were evaluated in an exploratory factor analysis (EFA), and the relationships between oxytocin, total CES-D score, and the resulting EFA factors were analyzed with multivariate linear regressions conducted in R. Multiple regression models were used to adjust for age, sex, body mass index, CD4, and education.ResultsContrary to hypothesized, higher peripheral oxytocin levels were associated with higher CES-D total scores with a small-to-moderate effect size (β = 0.26, p = .009). Following Bonferroni correction, oxytocin was not significantly associated with any of the five factors identified from the EFA: depressed affect, positive affect, appetite, cognitive symptoms, or perceived failure (p values > .042). Small effect sizes were found for the depressed affect (β = 0.22) and perceived failure (β = 0.21) factors (p values > .042).ConclusionsIn a sample of predominately Black or African American individuals with HIV, higher oxytocin was associated with higher total depressive symptoms. In addition, this relationship was slightly stronger than those of specific depressive symptoms. These findings warrant further study into the role of oxytocin in mood symptoms within PWH.

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The association of oxytocin with major depressive disorder: role of confounding effects of antidepressants

Cited by 10 publications

References 224 publications

Neural Functions of Hypothalamic Oxytocin and its Regulation

Neural Functions of Hypothalamic Oxytocin and its Regulation

Functional modular networks identify the pivotal genes associated with morphine addiction and potential drug therapies

The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV

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