The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV

Shortell, Destin D.; Rubin, Leah H.; Murphy, Aidan J.; Cohen, Ronald A.; Porges, Eric C.

doi:10.1097/psy.0000000000001122

Cited by 2 publications

(2 citation statements)

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“…Accordingly, Drivsholm et al hypothesized that alterations in the KYN pathway might partly mediate a close relationship between macrophage-driven inflammation and depression in HIV infection [69]. Finally, Shortell et al report a correlation between neuropeptide oxytocin and depressive symptoms in PLWH (Table 1) [73].…”

Section: Studies Investigating Monoamine Metabolites and Hormonesmentioning

confidence: 99%

Bidirectional Relationship between HIV/HBV Infection and Comorbid Depression and/or Anxiety: A Systematic Review on Shared Biological Mechanisms

Fabrazzo,

Cipolla,

Pisaturo

et al. 2023

JPM

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Background: Mental disorders that are comorbid with chronic infectious diseases may worsen clinical outcomes and patients’ quality of life. We hypothesized that depression and/or anxiety syndromes or symptoms comorbid with human immunodeficiency virus (HIV) or hepatitis B virus (HBV) infection might stem from shared biological mechanisms. Methods: We conducted a systematic review applying the PRISMA statement by searching into the PubMed, APA PsycInfo, and Scopus databases. We examined the literature on HIV/HBV infection comorbid with depression and/or anxiety in adults ≥18 years. Results: Thirty-one studies on HIV and three on HBV were analyzed. The Tat protein contributed to HIV-associated mood disorders due to the protein’s ability to cause neurodegeneration and induce hypothalamic–pituitary–adrenal (HPA) axis dysregulation in response to natural stressors. The decreased brain-derived neurotrophic factor (BDNF) levels also emerged as a mechanism involved in HIV neuropathogenesis and the associated mood symptoms. Neuroinflammation was implicated in depression and/or anxiety onset in patients with HIV/HBV infections. Microglial activation and release of cytokines, in particular, appeared as potential pathogenetic mechanisms. Furthermore, an altered balance between quinolinic acid and kynurenic acid production emerged in HIV patients with comorbid depression, indicating a glutamatergic dysfunction. Inflammatory cytokine production and the downregulation of cellular immune responses contributed to persisting inflammation, delayed healing, and functional decline in patients with chronic hepatitis B (CHB) infection. A shift in type 1–type 2 cytokine balance might be implicated in HBV-related immune pathogenesis, and depression and anxiety might be considered immunomodulatory factors. Cytokines also caused HPA axis hyperactivity, frequently observed in HIV/HBV patients with comorbid depression/anxiety. Conclusions: The present systematic review showed, for the first time, that HIV/HBV and depression and/or anxiety might have several biological mechanisms as common denominators. The longitudinal course of the highlighted biological mechanisms should be explored to establish the causative interrelationship among the involved mechanisms. In addition, future research should investigate the possibility that a patient’s clinical outcome might improve using pharmacological treatments acting on the biological mechanisms we described as common denominators of chronic inflammatory infective diseases and depression/anxiety.

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Section: Studies Investigating Monoamine Metabolites and Hormonesmentioning

confidence: 99%

Bidirectional Relationship between HIV/HBV Infection and Comorbid Depression and/or Anxiety: A Systematic Review on Shared Biological Mechanisms

Fabrazzo,

Cipolla,

Pisaturo

et al. 2023

JPM

View full text Add to dashboard Cite

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“…This cross-sectional study documented that PWH who experienced early life stress had higher levels of oxytocin and inflammation that paralleled greater difficulties with facial emotion recognition, one important aspect of social processing. Shortell and colleagues ( 20 ) also report an association of higher oxytocin with greater depressive symptoms in a sample of predominantly Black/African American PWH. In another study in this issue, Rubin and colleagues ( 21 ) examined whether alterations in glucocorticoid receptor gene expression were associated with cognitive function in PWH.…”

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confidence: 91%

The Interaction of HIV With Mental Health in the Modern Antiretroviral Therapy Era

Rubin

Paul

2022

Psychosom Med

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People with HIV (PWH) receiving effective antiretroviral therapy (ART) continue to display residual immune dysregulation that amplifies the risk for neuropsychiatric comorbidities. At the same time, PWH commonly experience intersectional stigma and other psychosocial stressors that are linked to neuroendocrine stress responses, potentiate residual immune dysregulation, and alter other biobehavioral processes relevant to health outcomes. This special issue of Psychosomatic Medicine seeks to advance our understanding of the intersection of HIV with mental health in the modern ART era. Several articles cover topics related to the prevalence and treatment of psychiatric comorbidities among PWH such as depression, suicidality, and substance use disorders. Other articles delineate biobehavioral mechanisms relevant to mental health in PWH such as inflammation, immune activation, neuroendocrine signaling, cellular aging, the microbiome-gut-brain axis, and neurobehavioral processes. Collectively, the articles in this special issue highlight the continued importance of biobehavioral and neurobehavioral mental health research in the modern ART era.

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The Association Between Peripheral Oxytocin Levels and Depressive Symptoms in People With HIV

Cited by 2 publications

References 83 publications

Bidirectional Relationship between HIV/HBV Infection and Comorbid Depression and/or Anxiety: A Systematic Review on Shared Biological Mechanisms

Bidirectional Relationship between HIV/HBV Infection and Comorbid Depression and/or Anxiety: A Systematic Review on Shared Biological Mechanisms

The Interaction of HIV With Mental Health in the Modern Antiretroviral Therapy Era

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