The Association of Non-Steroidal Anti-Inflammatory Drugs with COVID-19 Severity and Mortality

Abstract

Background: No specific study has investigated the effect of non-steroidal anti inflammatory drugs (NSAIDs) and especially the effects of Ibuprofen on COVID-19, so far. Objectives: The purpose of this study was to investigate the effect of Ibuprofen on the severity of COVID-19 and mortality caused by the disease. Methods: This study was conducted on 158 patients with COVID-19 who had consumed Ibuprofen, Gelofen, and Novafen for at least one week in the last three months. Patients were divided into three groups (mild, moderate and sever). The relationship among the severity of the disease and the history of ibuprofen consumption, diabetes, history of cardiovascular problems, hypertension, and GFR was investigated. Also, the association between the history of ibuprofen consumption, GFR ≤ 60 mL/min, hypertension, LDH ≥ 500 U/L, lymphocyte count ≤ 1500, and mortality was examined. Results: Our findings showed a significant relationship between the history of Ibuprofen before COVID-19 and the severity of COVID-19, as well as the mortality rate (P value < 0.001, adjusted odd ratio: 2, respectively). This study also showed a significant relationship among the severity of the disease and the history of smoking, diabetes, hypertension, history of cardiovascular diseases, and GFR. In addition, a significant relationship was found among GFR ≤ 60 mL/min mortality, diabetes, LDH ≥ 500 U/L, and lymphocyte count ≤ 1500. Conclusions: Our study showed a significant relationship between the history of the consumption of ibuprofen and its compounds before COVID-19 and the severity of COVID-19, as well as the mortality rate of the patients with this disease, and accordingly, this result can suggest health policies during the epidemic of COVID-19.

NSAIDs and COVID-19: A Systematic Review and Meta-analysis

“…Two papers mentioning reviews in the title were identified: one related to ibuprofen and acute bacterial or viral respiratory lower tract infections [6], while the other was a narrative review of the issues involved [7]. We found no other systematic reviews on this topic, while some papers of potential interest provided no usable data [8,9]. In ClinicalTrials.gov, 22 studies cited COVID and NSAIDs, a few of which might be of interest when completed or published, i.e.…”

The Effect of Remdesivir in Patients with Severe COVID-19, Reporting Case Series

“…Yet, in agreement with most other studies, the results of the present study confirmed the relationship between administration of interferon and patient recovery. In comparison, considering the effects of different medication groups such as nonsteroidal anti-inflammatory medications like ibuprofen, or medications such as famotidine or N-acetylcysteine, which are effective in managing the inflammatory phase in patients with moderate to severe COVID-19, paying particular attention to the effect of antivirals (with virus-specific action) is highly important in patients with COVID (14)(15)(16).…”

The Association Between ABO-Rh Blood Groups and the Risk of COVID-19 Infection

“…Limited data have been provided as predisposing fac-tors, such as NSAID consumption (7). COVID-19 spread worldwide as an unexpected disaster and has remained a global public health concern thus far.…”