The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive–compulsive disorder

Atmaca, Murad; Önalan, Ebru Etem; Yıldırım, Hanefi; Yüce, Hüseyin; Koç, Mustafa; Korkmaz, Sevda

doi:10.1016/j.jad.2010.03.027

Cited by 30 publications

(26 citation statements)

References 21 publications

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“…association between OCD and dopaminergic genes -such as the DAT1 VNTR gene variant -could be confirmed and only very small effect sizes have been shown for DAT1 in OCD so far (see review Brem et al, 2014). Atmaca et al (2010) recently published a study that combined magnetic resonance imaging measurements with analysis of the myelin oligodendrocyte glycoprotein (MOG) gene polymorphism, which was of interest in the context of OCD because of the positive results of a family-based association study (Zai et al, 2004). The work of Atmaca et al (2010) demonstrated that the total white matter volumes of OCD patients were larger than those of healthy controls, particularly among patients carrying the MOG G511C (Val142Leu) Val/Val genotype.…”

Section: Nomentioning

confidence: 99%

“…Atmaca et al (2010) recently published a study that combined magnetic resonance imaging measurements with analysis of the myelin oligodendrocyte glycoprotein (MOG) gene polymorphism, which was of interest in the context of OCD because of the positive results of a family-based association study (Zai et al, 2004). The work of Atmaca et al (2010) demonstrated that the total white matter volumes of OCD patients were larger than those of healthy controls, particularly among patients carrying the MOG G511C (Val142Leu) Val/Val genotype. Similarly, a publication by Wolf et al (2013) combined the magnetic resonance imaging technique with the examination of a polymorphism (rs1006737) in a gene that encodes the alpha-1C subunit of the L-type voltage-gated calcium channel (CACNA1C), which has been implicated in structural and functional variation in the amygdala in healthy people as well as in patients with bipolar disorder or schizophrenia (Jogia et al, 2011;Perrier et al, 2011;Tesli et al, 2013;Wessa et al, 2010).…”

Section: Nomentioning

confidence: 99%

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Imaging genetics in obsessive-compulsive disorder: Linking genetic variations to alterations in neuroimaging

Grünblatt

Hauser

Walitza

2014

Progress in Neurobiology

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Obsessive-compulsive disorder (OCD) occurs in ∼1-3% of the general population, and its often rather early onset causes major disabilities in the everyday lives of patients. Although the heritability of OCD is between 35 and 65%, many linkage, association, and genome-wide association studies have failed to identify single genes that exhibit high effect sizes. Several neuroimaging studies have revealed structural and functional alterations mainly in cortico-striato-thalamic loops. However, there is also marked heterogeneity across studies. These inconsistencies in genetic and neuroimaging studies may be due to the heterogeneous and complex phenotypes of OCD. Under the consideration that genetic variants may also influence neuroimaging in OCD, researchers have started to combine both domains in the field of imaging genetics. Here, we conducted a systematic search of PubMed and Google Scholar literature for articles that address genetic imaging in OCD and related disorders (published through March 2014). We selected 8 publications that describe the combination of imaging genetics with OCD, and extended it with 43 publications of comorbid psychiatric disorders. The most promising findings of this systematic review point to the involvement of variants in genes involved in the serotonergic (5-HTTLPR, HTR2A), dopaminergic (COMT, DAT), and glutamatergic (SLC1A1, SAPAP) systems. However, the field of imaging genetics must be further explored, best through investigations that combine multimodal imaging techniques with genetic profiling, particularly profiling techniques that employ polygenetic approaches, with much larger sample sizes than have been used up to now.

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Section: Nomentioning

confidence: 99%

Section: Nomentioning

confidence: 99%

Imaging genetics in obsessive-compulsive disorder: Linking genetic variations to alterations in neuroimaging

Grünblatt

Hauser

Walitza

2014

Progress in Neurobiology

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“…Many recent studies have demonstrated that there are volume changes in the anatomical structures of the brain and changes in the biochemical and spectroscopic variables of psychiatric diseases. [1][2][3][4][5] Neuroimaging research has begun to provide valuable insights into the neurobiological substrates that mediate the maladaptive processing of social information in SAD. One of the most intensely studied neural regions in SAD is the amygdala, its well-established role in fear and social processing.…”

Section: Introductionmentioning

confidence: 99%

The investigation of hippocampus and amygdala volume changes with MRI in patients with social anxiety disorder

Koç¹,

Kuloğlu²,

Yıldırım³

et al. 2017

Anadolu Psikiyatri Derg

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“…11–13 Moreover, OCD patients have also shown myelin abnormalities, in terms of white matter volume and microstructure, primarily located within the fronto-striato-thalamo-cortical circuit. 14–16 Thus, the relationship between compulsivity and white matter abnormalities appear to be important behavioral and biological markers of vulnerability to compulsive spectrum disorders.…”

Section: Introductionmentioning

confidence: 99%

Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders

Navarro

Álvarez

Colomina

et al. 2016

Schizophrenia Bulletin

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Psychogenic polydipsia, which is compulsive, non-regulatory fluid consumption, is present in 6%–20% of chronic psychiatric patients and frequently associated with the schizophrenia diagnosis. In the present study, we investigated the relation between schizophrenia-like symptoms and biomarkers with a compulsive drinking behavior phenotype in rats. Rats that were selected for low drinking vs high drinking behavior following schedule-induced polydipsia (SIP) were assessed in a latent inhibition (LI) paradigm using tone and electrical foot shock and in a spatial reversal learning task to evaluate behavioral inflexibility. We also analyzed the myelin basic protein in different brain areas of high drinker (HD) and low drinker (LD) rats. The HD rats, which were characterized by a compulsive drinking behavior on SIP, had a reduced level of LI effect and increased behavioral inflexibility in the spatial reversal learning task in comparison to the LD group. Moreover, HD rats showed less myelination in the center of the corpus callosum, striatum, and amygdala in comparison to LD rats. These findings strengthen the validity of HD rats that were selected by SIP as a possible phenotype of compulsive neuropsychiatric disorders, as evidenced by the existence of behaviors and biological markers that are related to schizophrenia and obsessive-compulsive disorder, including a reduced LI effect, behavioral inflexibility and reduced brain myelination. Future studies could contribute to the elucidation of the mechanisms underlying the compulsive phenotype of HD rats and its relation to vulnerability to schizophrenia.

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The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive–compulsive disorder

Cited by 30 publications

References 21 publications

Imaging genetics in obsessive-compulsive disorder: Linking genetic variations to alterations in neuroimaging

Imaging genetics in obsessive-compulsive disorder: Linking genetic variations to alterations in neuroimaging

The investigation of hippocampus and amygdala volume changes with MRI in patients with social anxiety disorder

Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders

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