The investigation of hippocampus and amygdala volume changes with MRI  in patients with social anxiety disorder

Koç, Mustafa; Kuloğlu, Ömer Cihat; Yıldırım, Hanefi; Atmaca, Murat Mert

doi:10.5455/apd.268817

Cited by 1 publication

(2 citation statements)

References 21 publications

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“…Similar to Syal et al (2012) and van Tol et al (2010) in younger samples, we found no association between HC volume and SAD. This contrasts with other studies reporting significantly positive associations between SAD and HC volume (Koç et al, 2018; Machado-de-Sousa et al, 2014), and smaller HC volume in patients with SAD (Irle et al, 2010; Liao et al, 2011). These results highlight the need for more research to understand the effect of SAD on the HC and the mechanisms involved, and how these change with age.…”

Section: Discussioncontrasting

confidence: 99%

“…In studies of human patients with anxiety disorders, most studies have focused on PTSD and have found that this condition is associated with reductions in HC volume (Kitayama et al, 2005). In SAD, research has shown hyperactivity in the HC in individuals (Etkin & Wager, 2007) and have found that those with a diagnosis of SAD exhibit larger HC volume compared to controls (Koç et al, 2018; Machado-de-Sousa et al, 2014), while others have observed significantly smaller HC volume compared to controls (Irle et al, 2010; Liao et al, 2011) or no difference in HC volume between individuals with SAD and controls (Syal et al, 2012). One study examining several anxiety disorders also found no HC volume reduction in SAD, GAD or PD patients (van Tol et al, 2010).…”

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confidence: 99%

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The association between anxiety disorders and hippocampal volume in older adults.

Baksh¹,

Ritchie²,

Terrera³

et al. 2021

Psychology and Aging

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The hippocampus, through its mediation of fear responses is thought to play a central role in the onset and maintenance of anxiety disorders. Prevalence of anxiety disorders remains high in older populations; however, little is known about their association with hippocampal changes in this age group. Due to differing levels of cortisol as adults age, age-related decreases in hippocampal volume, and the suggestion that age-related loss of neurogenesis results in anxiety disorders, this area requires investigation. We examined the association between hippocampal volume and anxiety disorders (social anxiety disorder, generalized anxiety disorder, agoraphobia, panic disorder, obsessive compulsive disorder and posttraumatic stress disorder) in 534 older adults participating in the Enquête de Santé Psychologique–Risques, Incidence et Traitement (ESPRIT) study of late-life neuropsychiatric disorders. Anxiety disorders were diagnosed using the Mini International Neuropsychiatric Interview MINI, French version 5.00. Cross-sectional analyses adjusted for age, educational level, gender, Mini-Mental State Examination scores, National Adult Reading Test scores, whole brain volume and depression found that a diagnosis of generalized anxiety disorder was positively associated with larger hippocampal volume. No other anxiety disorder was significantly associated with hippocampal volume. The present study is the first to examine the association between several anxiety disorders and hippocampal volume in an older population and the results highlight the need for further research relating to the relationship between hippocampal volume and anxiety disorders in older adults.

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