The Association of Gene Polymorphisms of Matrix Metalloproteinases (-9, -12 and -20) and Collagen Type I Degradation Products With the Remodeling of the Left Ventricle in Patients With Acute Myocardial Infarction

Sokolova, N. A.; Danshova, M. S.; Говорин, А. В.; Zaytsev, D.N.; Smolyakov, Yu. N.

doi:10.18087/cardio.2018.3.10093

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Only a few studies were found about the association of the MMP-9 genotype with the size of the heart chambers. In patients with acute myocardial infarction, the presence of the G allele of the rs17576 polymorphism MMP-9 gene and other factors increased the likelihood of hypertrophic left ventricular remodeling [27]. Also, the presence of the minor allele G of the rs17576 polymorphism of the MMP-9 gene and the C allele of the MMP-20 rs2245803 gene (CK = -2.228) enhanced its association with hypertrophic changes in left ventricle geometry [27].…”

Section: Discussionmentioning

confidence: 99%

Association of MMP-9 Genetic Polymorphism and Ммр-9 Concentration With Echocardiographic Parameters in Ukrainian Patients With Coronary Artery Disease

Погорєлова

Korniienko

Chumachenko

et al. 2022

EUMJ

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Introduction. Cardiovascular diseases are the main cause of reduced life expectancy, workability, and death among the people of Eastern Europe. Matrix metalloproteinase-9 (MMP-9) is known as one of the leading factors involved in the development and progression of atherosclerosis and heart remodeling. The increasing sizes of the heart’s chambers lead to changes in the electrophysiological properties of the myocardium and to the subsequent occurrence of arrhythmias and conduction disorders. Materials and methods. The study included 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS) and 63 patients with chronic coronary syndrome (CCS) to investigate the effect of MMP-9 polymorphism and its serum concentration on changes in echocardiographic parameters. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus and ELISA study was performed to measure the MMP-9 plasma concentration. Results. Statistically significant differences were found in the thickness of the posterior wall of the heart among carriers of the G-allele and AA-homozygotes for the MMP-9 rs17576-single nucleotide polymorphism but only in patients with ACS. The size of the left ventricle posterior wall can be predicted for carriers of these genotypes. Conclusions. The study revealed no statistically significant relationship between MMP-9 concentration and echocardiographic parameters in patients with ACS and CCS. However, there were statistically significant differences in the left atrium diameter and thickness of the posterior wall of the left ventricle depending on the genotype for MMP-9 rs17576-single nucleotide polymorphism only in patients with ACS. The size of the posterior wall of the left ventricle can be predicted for carriers of AG and GG genotypes.

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Section: Discussionmentioning

confidence: 99%

Association of MMP-9 Genetic Polymorphism and Ммр-9 Concentration With Echocardiographic Parameters in Ukrainian Patients With Coronary Artery Disease

Погорєлова

Korniienko

Chumachenko

et al. 2022

EUMJ

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“…Диастолическая дисфункция ЛЖ (ДДЛЖ) является одним из патогенетических механизмов 2 , p χ 2 = 6,11 p = 0,00124 χ 2 = 9,9 p = 0,00001 χ 2 = 5,9 p =0,0123 χ 2 = 6,98 p=0,00001 аллель -786T данного гена, встречается достоверно чаще у лиц с нормальными значениями СПВ.…”

Section: результатыunclassified

“…Содержащиеся в доступной литературе сведения свидетельствуют о несомненной клинической значимости изучения полиморфизма генов у больных с сердечно-сосудистыми заболеваниями (ССЗ) с точки зрения возможности стратификации риска развития ССО на основании генетического тестирования [2][3][4].…”

Section: Introductionunclassified

Relationship of gene polymorphism with the nature of target organ damage in patients with arterial hypertension

Drobotya

Arutyunyan²,

Пироженко

et al. 2020

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Objective: to assess the relationship of polymorphism of the main genes involved in the pathogenesis of arterial hypertension (AH) with indicators reflecting the state of target organs in the group of patients with arterial hypertension.Material and methods: we examined 100 patients with arterial hypertension who underwent standard diagnostic procedures, as well as molecular genetic research.Results: in patients with arterial hypertension statistically significant associations of AGTR2, GNB3, and NOS3 gene polymorphism with left ventricular hypertrophy, CYP11B2 and NOS3 gene polymorphism with left ventricular diastolic dysfunction, and NOS3 gene polymorphism with increased vascular wall stiffness were found (p < 0.05).Conclusions: the results of the study indicate that patients with arterial hypertension are a genetically heterogeneous group in terms of the relationship of specific gene polymorphism with indicators that characterize the state of target organs. The use of genetic approaches is promising for early screening of patients with arterial hypertension, belonging to the high-risk group, in order to ensure timely and effective organoprotection.

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Factors associated with post-infarction myocardial remodeling

Lozhkina

Mukaramov

2021

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This article analyzes the problem of postinfarction myocardial remodeling in the current availability of high-tech methods of coronary revascularization in most countries. The authors discuss both wellstudied factors that determine the transformation of acute myocardial injury into chronic heart failure syndrome and new fundamental ones that determine prognosis and treatment. Used information on the topic from publications over the past five years, based on the PubMed, Google Scholar and Russian Science Citation Index databases.

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The Association of Gene Polymorphisms of Matrix Metalloproteinases (-9, -12 and -20) and Collagen Type I Degradation Products With the Remodeling of the Left Ventricle in Patients With Acute Myocardial Infarction

Cited by 3 publications

References 5 publications

Association of MMP-9 Genetic Polymorphism and Ммр-9 Concentration With Echocardiographic Parameters in Ukrainian Patients With Coronary Artery Disease

Association of MMP-9 Genetic Polymorphism and Ммр-9 Concentration With Echocardiographic Parameters in Ukrainian Patients With Coronary Artery Disease

Relationship of gene polymorphism with the nature of target organ damage in patients with arterial hypertension

Factors associated with post-infarction myocardial remodeling

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