The association between vitamin D concentration and pain: a systematic review and meta-analysis

Wu, Zhenqiang; Malihi, Zarintaj; Stewart, Alistair; Lawes, Carlene M.M.; Scragg, Robert

doi:10.1017/s1368980018000551

Cited by 99 publications

(97 citation statements)

References 98 publications

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“…In a review study by Wu et al, the results indicated that vitamin D supplement effectively alleviated the severity of chronic pain. 44 This micronutrient may be effective in reducing the severity of pain through this mechanism: Vitamin D receptor plays a major role in regulating steroid hormones in the female reproductive system. 45 The function of biologically active form of vitamin D, called 1, 25-dihydroxyvitamin D, in endometrium causes a reduction in the synthesis of prostaglandins by suppressing cyclooxygenase 2 expressions.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis

et al. 2020

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Introduction: Primary dysmenorrhea is considered as one of the main problems in women. This review study aimed to characterize the effect of micronutrients on primary dysmenorrhea. Methods: In this systematic and meta‐analysis study, the articles were searched at Cochrane library, PubMed, Scopus, Web of Science databases. The searching process was conducted with the key terms related to dysmenorrhea and micronutrients. Risk of bias assessment was performed, using Rev Man 5.3 software. In view of the heterogeneity of some of the studies, they were analyzed, using a qualitative method (n=10), and only 6 studies were included in Meta analyze. STATA statistical software version 11 was used for the analysis. Results: In this study, finally 16 clinical trials were investigated. Most micronutrients studied in the relevant articles had anti-inflammatory and analgesic properties with a desirable effect on dysmenorrhea pain relief. Vitamins (K, D, B1, and E) and calcium, magnesium, zinc sulfate and boron contributed effectively to dysmenorrhea pain management. Two months after the intervention, there was a significant mean decrease in the pain score for the vitamin D intervention group (SMD: -1.02, 95% CI: -1.9 to – 0.14, P =0.024) , as well as in the vitamin E intervention group compared to placebo group (SMD: - 0.47,95% CI:-0.74 to – 0.2, P = 0.001). Conclusion: Despite the paucity of related research, the studies indicated the potential effects of micronutrients on reducing the pain severity in primary dysmenorrhea. But more studies are needed to confirm the safety and effectiveness of various types of micronutrients on primary dysmenorrhea.

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Section: Discussionmentioning

confidence: 99%

The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis

et al. 2020

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“…On the other hand, it has been proposed that insufficient levels of vitamin D might be an unknown reason for initiation and augmentation of pain sensitization, its severity and neuromuscular dysfunction in the subjects who suffer from chronic pain; if so, supplementation with this vitamin can be helpful in improving pain. In this regard, any interventional procedure that is thought to blunt these pathways could act as a pain relieving agent . The role of 1,25 (OH)2 D in modifying genetic pathways in the target cells is performed via its nuclear receptor or vitamin D receptor (VDR).…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin D Status in a Group of Migraine Patients Compared With Healthy Controls: A Case–Control Study

et al. 2018

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Objective The association between serum vitamin D and migraine is investigated in this research.s Background Although the pathogenesis of migraine headache is not fully understood, the possible role of inflammation and disturbed immune system has been proposed; thus, higher levels of vitamin D might reduce the risk of migraine. However, the results of related studies have been inconclusive. Methods Seventy healthy individuals and 70 age‐ and sex‐matched migraineurs (34 chronic and 36 episodic migraineurs), diagnosed according to the International Headache Society criteria (ICHD‐IIIβ), were recruited. After obtaining baseline data and assessing migraine disability, a 30‐day headache diary was given to the participants. Blood samples were obtained and 25(OH)D serum concentrations were determined using ELISA techniques. Serum 25(OH)D under 20, 20–29, and 30–100 ng/mL were considered deficient, insufficient, and sufficient, respectively. The applied statistical tests for between‐group comparisons include independent‐sample t‐test, chi‐square, and analysis of variance. Multiple regression analysis was also performed to identify the possible risk factors of migraine headache. Results Migraine patients had significantly lower mean (SD) of serum VitD (30 (16) ng/mL) than healthy subjects (43 (19) ng/mL) (P < .001). The number (%) of subjects with VitD deficiency and insufficiency was significantly higher among the migraineurs (36 (53.7%)) than the controls (18 (26.1%)) (P < .0001). A significant negative association between migraine headache and serum VitD was detected in the fully adjusted multiple regression models when comparing the third and the highest serum 25(OH)D quartiles with the lowest (OR = 0.20; 95% CI = 0.05–0.77; OR = 0.17; 95% CI = 0.04–0.64, respectively, P for trend = .009). For each 5 ng/mL increase in serum 25(OH)D, there was a 22% odds decrease in the odds of migraine (OR = 0.78; 95% CI = 0.68–0.90; P = .001). Conclusion We have found that a higher level of serum VitD (between 50 to less than 100 ng/mL) among a sample of the Iranian population is associated with 80–83% lower odds of migraine headache than those with serum 25(OH)D levels below 20 ng/mL. However, there is a need for well‐designed clinical trials to investigate beneficial effects of increased serum 25(OH)D on lower risk of migraine.

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“…Kronik ve nonspesifik kas iskelet sistem ağrısı olanlarda vitamin D düşüklüğü prevalansının yüksek olduğu bildirilmiştir (10). D vitamini eksikliği karşımıza kas iskelet problemleri şeklinde çıkabilir (11,12) ve FMS'dekine benzer semptomlara yol açabilir (13).…”

Section: Discussionunclassified

Fibromiyalji Sendromunda D Vitamin Düzeylerinin Değerlendirilmesi

Özgen

Aydoğan²,

Uygur³

et al. 2018

Osmangazi̇ Journal of Medicine

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Özet: Bu çalışmanın amacı, fibromiyalji sendromu olan hastalarda 25(OH)D düzeyini değerlendirmek ve hassas nokta sayısı ile 25(OH)D düzeyi arasındaki ilişkiyi araştırmaktı. Bu retrospektif çalışmaya, 2016-2017 yılları arasında fibromiyalji tanısı almış 61 hasta dahil edildi. Hastaların demografik verileri, 25(OH)D düzeyleri, hassas nokta sayıları değerlendirildi. Hastalar 25(OH)D düzeyleri göre; D vitamini eksikliği (<20 ng/ml), D vitamini yetersizliği (20-30 ng/ml) ve normal D vitamini düzeyi olarak (>30 ng/ml) sınıflandırıldı. Fibromiyalji tanısı olan 61 hastanın 25(OH)D düzeyleri ortalaması 18,08±11,72 idi. D vitamin düzeyleri incelendiğinde, 40 fibromiyalji hastasında D vitamini eksikliği, 14 fibromiyalji hastasında D vitamini yetersizliği olduğu saptandı. Fibromiyalji tanısı olan hastaların sadece 7'sinde (%11,48) D vitamin düzeyleri normal seviyede bulunmuştur. Hastaların 25(OH)D düzeyleri ve hassas nokta sayıları arasında anlamlı bir korelasyon gözlemlenmedi. Fibromiyaljili hastaların büyük çoğunluğunda vitamin D düzeylerinin düşük olduğu, bununla birlikte fibromiyaljili hastalarda saptanan hassas nokta sayısının 25(OH)D değerleriyle ilişkili olmadığı sonucuna varılmıştır.Abstract: The aim of this study was to evaluate 25(OH)D levels in patients with fibromyalgia syndrome and to investigate the relationship between tender point count and 25(OH)D levels.Sixty one patients with a diagnosis of fibromyalgia were included in this retrospective study between 2016-2017. Demographic data of patients, 25(OH)D levels, number of tender points were evaluated. Patients were classified as vitamin D deficiency (<20 ng/ml), vitamin D insufficient (20-30 ng/ml) and normal vitamin D level (> 30 ng /ml) according to 25(OH)D levels. The mean 25(OH)D levels of 61 patients with firomyalgia was 18.08±11.72. When vitamin D levels were examined, vitamin D deficiency was found in 40 patients with fibromyalgia and vitamin D deficiency in 14 patients with fibromyalgia. Only 7 (11,48%) of the patients with fibromyalgia had normal vitamin D levels. There was no significant correlation between 25(OH)D levels and tender point counts of patients. It was concluded that the vitamin D levels were low in the majority of patients with fibromyalgia, however the number of tender point detected in patients with fibromyalgia was not related to 25(OH)D values.

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The association between vitamin D concentration and pain: a systematic review and meta-analysis

Abstract: A significantly lower 25(OH)D concentration was observed in patients with arthritis, muscle pain and chronic widespread pain, compared with those without. These results suggest that low 25(OH)D concentrations may be associated with pain conditions.

Cited by 99 publications

References 98 publications

The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis

The Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta‐Analysis

Serum Vitamin D Status in a Group of Migraine Patients Compared With Healthy Controls: A Case–Control Study

Fibromiyalji Sendromunda D Vitamin Düzeylerinin Değerlendirilmesi

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