The Association Between Use of Hypofractionation and Treatment Completion Among Recipients of Radiation Therapy Post-Mastectomy

Powell, Adam C.; Rogstad, Teresa L.; Jacob, Nandita M.; Long, James W.; Deshmukh, Uday U.; Loy, Bryan A.; Mirhadi, Amin

doi:10.1016/j.prro.2019.10.009

Cited by 7 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypofractionation was associated with higher rates of on-time completion (46.5% v 17.8%, P < .001) and timely completion (75% v 52%, P < .001) of radiotherapy. 46 The two NCDB studies were consistent with these results and reported higher overall completion rates (99.3% v 79.7%, P < .0001) and timely completion rates (94.5% v 74.8%, P < .0001) which was defined as treatment completion within 5 weeks of initiation of hypofractionated radiotherapy or 7 weeks for conventionally fractionated treatments. 44 , 47 Importantly, racial and socioeconomic disparities in treatment completion rates and tumor control were narrowed when a hypofractionated radiotherapy approach was used because of higher rates of treatment compliance and completion.…”

Section: Methodssupporting

confidence: 67%

“…Three studies from the United States, including one institutional study and two National Cancer Database (NCDB) studies, reported similar findings. 44 , 46 , 47 The institutional study reported on 743 patients with breast cancer, 56 of which were treated with hypofractionated therapy and reported on rates of on-time completion (defined as treatment completion assuming treatment is given 5 days per week with an additionally 7-day buffer) and timely completion (similar to on-time but with a 30-day buffer) of radiotherapy. Hypofractionation was associated with higher rates of on-time completion (46.5% v 17.8%, P < .001) and timely completion (75% v 52%, P < .001) of radiotherapy.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Benefits of Adopting Hypofractionated Radiotherapy as a Standard of Care in Low-and Middle-Income Countries

Kraus

Weil

2022

JCO Global Oncology

View full text Add to dashboard Cite

show abstract

Section: Methodssupporting

confidence: 67%

Section: Methodsmentioning

confidence: 99%

Benefits of Adopting Hypofractionated Radiotherapy as a Standard of Care in Low-and Middle-Income Countries

Kraus

Weil

2022

JCO Global Oncology

View full text Add to dashboard Cite

show abstract

“…1 Furthermore, prior research has shown there is an association between the selection of an HF RT regimen and treatment completion, in the context of patients receiving RT after mastectomy. 14 Although the patient population slightly differed from the post-lumpectomy population examined by this study, this finding suggests that the VTB's efforts to promote HF RT may have positive implications for treatment completion.…”

Section: Discussionmentioning

confidence: 58%

Rate of Whole-Breast Hypofractionated Radiation Therapy Before Versus After Virtual Tumor Board Implementation

Powell¹,

Ceylan²,

Long

et al. 2021

JCO Oncology Practice

View full text Add to dashboard Cite

PURPOSE: The virtual tumor board (VTB) is a multidisciplinary group of specialist physicians who remotely educate the treating physician on the development of an evidence-based cancer treatment plan that will enhance patient outcomes according to the available literature. The use of hypofractionated (HF) radiation therapy (RT) is a preferred approach according to National Comprehensive Cancer Network guidelines and is encouraged by the VTB, when appropriate. MATERIALS AND METHODS: An observational, cohort study using prior authorization and claims data were conducted to show how the relative use of HF and conventional fractionated (CF) RT changed after the implementation of the VTB. Orders and claims for qualifying patients from 1 year before launch (August 2016) to 1 year after launch (August 2018) of the VTB were extracted. Claims were examined to observe which patients received CF (28-35 fractions) versus HF (15-21 fractions) RT. χ2 tests were used to assess the association between time period and the ordering and use of HF RT. Logistic regressions were used to test the association, after adjusting for the patient’s age, urbanicity, local average income, and the RT modality used. RESULTS: After implementation, we observed a significantly higher percentage of orders for HF RT (60.3% [n = 1,254 of 2,079] v 53.2% [n = 1,010 of 1,899]; P < .001) and claims for HF RT (71.5% [n = 1,143 of 1,598] v 59.0% [n = 941 of 1,595]; P < .001). Relative to before implementation, the adjusted odds of an order for HF RT was 1.35 (CI, 1.19 to 1.54), and the adjusted odds of a claim for HF RT was 1.76 (CI, 1.52 to 2.04). CONCLUSION: After the VTB was implemented, there was a significant increase in HF RT orders and claims.

show abstract

“…Hypofractionation consists of delivery of more than 2.0 Gy daily per fraction over 3-4 weeks, to a total dose that is radiobiologically equivalent to the SF (8)(9)(10)(11). While the efficacy and tolerability of the SF treatment schedule is well-established, challenges of this prolonged course include inconvenience to the patient, escalation of healthcare costs, and excess use of resources (12)(13)(14)(15)(16)(17). Using data modelling, Khan et al demonstrated that wide-spread adoption of shorter WBI or PMRT schedules can result in significantly increased access and improved survival for breast cancer patients, which is particularly important in regions where RT access is limited (18).…”

Section: Introductionmentioning

confidence: 99%

Hypofractionated Postmastectomy Radiation Therapy

Sayan

Yehia

Ohri

et al. 2021

Advances in Radiation Oncology

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

The Association Between Use of Hypofractionation and Treatment Completion Among Recipients of Radiation Therapy Post-Mastectomy

Cited by 7 publications

References 13 publications

Benefits of Adopting Hypofractionated Radiotherapy as a Standard of Care in Low-and Middle-Income Countries

Benefits of Adopting Hypofractionated Radiotherapy as a Standard of Care in Low-and Middle-Income Countries

Rate of Whole-Breast Hypofractionated Radiation Therapy Before Versus After Virtual Tumor Board Implementation

Hypofractionated Postmastectomy Radiation Therapy

Contact Info

Product

Resources

About