The association between TNFR gene polymorphisms and the risk of Hepatitis B Virus-Related Liver Diseases in Chinese population

Abstract

Tumor necrosis factor receptor superfamily 2 (TNFR2) plays an important role in controlling the progression of antiviral and antitumorr. Evidence suggests that TNFR2 is involved in the pathogenesis of HBV-induced liver injury. We therefore examined whether TNFR2 polymorphisms are associated with the risk of HBV-related liver disease in Chinese population. In this case-control study, 115 chronic hepatitis B (CHB) patients, 86 HBV-related liver cirrhosis patients (LC), 272 HBV-related hepatocellular carcinoma patients (HCC) and 269 healthy controls were recruited. TNFR2 rs1061622 and rs1061624 polymorphisms were examined using a polymerase chain reaction-restriction fragment length polymorphism analysis. Binary logistic regression analyses revealed that the A allele of rs1061624 was positively associated with the risk of CHB (AA vs. GG, P = 0.026; AA vs. GA+GG, P = 0.021), LC (AA vs. GG, P = 0.027; AA+GA vs. GG, P = 0.036), and HCC (GA vs. GG, P = 0.046; GA+AA vs. GG, P = 0.031). Moreover, subgroup analysis indicated that male subjects have increased risk in developing CHB and LC. Nevertheless, no association was found between rs1061622 polymorphism and HBV-related liver diseases in the overall or subgroup analyses. Our retrospective study suggests that the TNFR2 rs1061624 polymorphism is associated with HBV-related CHB, LC, and HCC in Chinese population, particularly in males.

Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis

“…All included studies should meet the following criteria: (1) investigate the association between any of the ve SNPs (-1031T/C, -863C/A, -857C/T, -308G/A, and -238G/A) in TNF-α gene and risk of HCC; (2) have cohort or case-control study design; (3) risk of HCC was reported as RR (relative risk) and/or OR (odds ratio) with 95% Con dence Interval (CI) or provide su cient data to extract RR and/or OR with 95% CI data; (4) include human subjects; (6) in English language. We excluded studies with the following criteria: (1) studies with design other than case-control or cohort;…”

The wild type alleles at positions 857 and 1031 in the Tumor Necrosis Factor gene promoter are highly conserved among the low/high endemic HBV infected persons in Uganda and may not be attributable to disease burden.

“…The susceptibility to infection and the clinical pro le during HBV infection varies at individual, population and regional levels (1). Consequently, the risk to infection, the clearance of the infection, the severity of the infection and the progression to chronic infection differs among individuals, communities, populations, ethnicities and races (1) (2). These differences emanate from genetic differences at the loci of the promoter regions of the immune modulatory molecules including the Tumor Necrosis Factor (TNF) alpha.…”

“…It is an example of the in ammatory cytokine and is important in the prognosis of the liver diseases following infection with hepatitis B virus (4). The TNF-α cytokine storm after the HBV exposure has been reported to have several effects:-rstly, accelerating liver brosis, cirrhosis and cancer (5) (6), secondly, affecting the expression levels of the Major Histocompatibility Complex (MHC) class II which in turn in uences the hepatitis B viral antigen presentation (7), thirdly, inhibiting the activities involved in the transcription of the HBV core promoter gene and nally inhibiting the HBV replication in the liver inducing viral clearance (8). Furthermore, the TNF-α has been reported to induce the production of reactive oxygen species free radicals.…”

Association between five types of Tumor Necrosis Factor-α gene polymorphism and hepatocellular carcinoma risk: a meta-analysis

“…Tumor Necrosis Factor-α (TNF-α) is an important inflammatory cytokine in the development of liver disease. This cytokine can cause hepatic injury, cirrhosis and eventually promote hepatocellular carcinoma [ 5 , 6 ]. Several previous studies have identified some Single Nucleotide Polymorphism (SNP) s in TNF-α gene, especially in the promoter region.…”