Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis

Wungu, Citrawati Dyah Kencono; Ariyanto, Fis Citra; Prabowo, Gwenny Ichsan; Soetjipto, Soetjipto; Handajani, Retno

doi:10.21203/rs.3.rs-26916/v2

Cited by 3 publications

(3 citation statements)

References 50 publications

(80 reference statements)

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“…Research has indicated that signal nucleotide polymorphisms (SNPs) in the TNF-α gene, including −863 C/A, −857 C/T, −308 G/A, and −238 G/A, are linked to the risk of developing HCC. These SNPs located on the TNF-α promoter can influence the level of TNF-α expression and lead to increased and continuous TNF-α production and are associated with a heightened HCC risk [23]. A substantial correlation was observed between the TNF-a GG genotype, and the occurrence of HCC [21].…”

Section: Chronic Inflammationmentioning

confidence: 99%

HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article

Milosevic,

Todorovic,

Filipovic

et al. 2023

IJMS

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Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) accounting for around one-third of all HCC cases. Prolonged inflammation in chronic hepatitis C (CHC), maintained through a variety of pro- and anti-inflammatory mediators, is one of the aspects of carcinogenesis, followed by mitochondrial dysfunction and oxidative stress. Immune response dysfunction including the innate and adaptive immunity also plays a role in the development, as well as in the recurrence of HCC after treatment. Some of the tumor suppressor genes inhibited by the HCV proteins are p53, p73, and retinoblastoma 1. Mutations in the telomerase reverse transcriptase promoter and the oncogene catenin beta 1 are two more important carcinogenic signaling pathways in HCC associated with HCV. Furthermore, in HCV-related HCC, numerous tumor suppressor and seven oncogenic genes are dysregulated by epigenetic changes. Epigenetic regulation of gene expression is considered as a lasting “epigenetic memory”, suggesting that HCV-induced changes persist and are associated with liver carcinogenesis even after cure. Epigenetic changes and immune response dysfunction are recognized targets for potential therapy of HCC.

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Section: Chronic Inflammationmentioning

confidence: 99%

HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article

Milosevic,

Todorovic,

Filipovic

et al. 2023

IJMS

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“…Similarly, functional studies have revealed that the G allele of the SNP variant −764G/C, situated nearby the IFN-γ promoter region, enhances promoter activity by a factor of two to three fold, correlating with both viral clearance and better treatment response in individuals with HCV infection [32]. In the context of malignancies, TNFα SNP (−863C/A, −857 C/T, −308 G/A, and −238 G/A) was strongly associated with a higher risk of hepatocellular carcinoma (HCC) [33], and the different combinations of SNPs of TNFα (−238G/A or −308G/A) with IL-10 (−592 C/A) were highly prevalent among patients with cervical cancer. PBMC (samples from patients with cervical cancer) activated with PHA also indicated that the TNFα (−308A/A) genotype demonstrated increased proliferation rates, elevated IL-4 and TGF-β, and decreased IL-2 levels [34], and it was postulated that SNPs of cytokine genes act as the potential predictors of cervical HPV infection progression to neoplasia.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Role of Human Leukocyte Antigen Alleles and Cytokine Single-Nucleotide Polymorphisms in Patients with Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitor Drugs

Birru,

Doxiadis,

Howe

et al. 2024

Genes

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Tyrosine kinase inhibitor (TKI) drugs have significantly improved chronic myeloid leukemia (CML) outcomes. Neopeptides from CML cells may induce specific immune responses, which are crucial for deep molecular (DMR) and treatment-free remission (TFR). In this study of Ethiopian patients with CML (n = 162), the HLA alleles and single-nucleotide polymorphisms of five cytokines revealed significant associations with clinical outcomes. Clinically unfavorable outcomes correlated with HLA alleles A*03:01/02, A*23:17:01, B*57:01/02/03, and HLA-DRB4*01:01 (p-value = 0.0347, p-value = 0.0285, p-value = 0.037, and p-value = 0.0127, respectively), while HLA-DRB4*01:03:01 was associated with favorable outcomes (p-value = 0.0058). After assigning values for the ‘low,’ ‘intermediate,’ and ‘high’ gene expression of the SNPs’ respective cytokine genes, Kaplan–Meier estimates for relapse-free survival, adjusted for age, treatment duration, and relapse risk among patients after the administration of TKIs, indicated that a gene expression ratio above the overall median of TNF-α, IL-6, and the combination of TGF-β1/IL-10, IFNγ, and IL-6/IL-10 TGF-β1 was correlated with a higher likelihood of treatment failure ((RR: 3.01; 95% CI: 1.1–8.3; p-value = 0.0261) and (RR: 2.4; 95% CI: 1.1–5.2; p-value = 0.022), respectively). Multi-SNPs, surpassing single-SNPs, and HLA allele polymorphisms showed promise in predicting outcomes of patients with CML during TKI treatment, prompting further exploration into their potential utility.

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“…In inheritance model analysis, the A/C-A/A genotype was related to a reduced risk of cervical cancer (P = 0.006, OR = 0.77; 95% CI = 0.64-0.93) in the dominant model. Previous studies have shown that rs1800630 is associated with gastric cancer and hepatocellular carcinoma [44,45], with the A allele of rs1800630 being a protective factor in the former but a risk factor in the latter. Our results show that the A allele of rs1800630 is a protective factor against cervical cancer (OR = 0.827; 95% CI = 0.715-0.959).…”

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confidence: 98%

The association of TNF-α promoter polymorphisms with genetic susceptibility to cervical cancer in a Chinese Han population

Yang

Wang

Zhang

et al. 2021

Preprint

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Background The Tumour necrosis factor-α (TNF-α) gene plays an important role in the host immune response. Recent studies have found that TNF-α also plays an important role in cancer. Polymorphism of the TNF-α promoter region is considered to influence its transcription and be a risk factor for tumorigenesis. In the current study, we evaluated the role of TNF-α promoter region polymorphisms in susceptibility to cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). Methods A total of 2,732 subjects, including 1,173 healthy controls, 579 patients with CIN and 980 patients with cervical cancer in a Chinese Han population, were selected for the current study. Five SNPs in the TNF-α promoter, rs1799964 (C > T), rs800630 (A > C), rs1799724 (C > T), rs1800629 (A > G) and rs361525 (A > G), were selected and genotyped using TaqMan Assays. The association of these SNPs with cervical cancer was evaluated among healthy controls and CIN and cervical cancer patients. Results The frequency distribution of rs1800629 and rs361525 alleles was significantly different between the cervical cancer group and the control group (P = 0.009 and P = 0.002). The A alleles of rs1800629 and rs361525 were found to be a protective factor (OR = 0.722; 95%CI = 0.564–0.923) and a risk factor (OR = 1.693; 95%CI = 1.205–2.378) for cervical cancer, respectively. In comparison of different pathological types of cervical cancer group and the control group, the distribution of allele frequencies of rs1800629 and rs361525 was significantly different between the squamous cell carcinoma and control groups (P = 0.002 and P < 0.001). The A alleles of rs1800629 and rs361525 were protective (OR = 0.659; 95%CI = 0.502–0.864) and risk (OR = 1.868; 95%CI = 1.317–2.648) factors for cervical squamous cell carcinoma, respectively. Conclusion rs1800629 and rs361525 in the TNF-α promoter are associated with susceptibility to cervical cancer and squamous cell carcinoma in the Chinese Han population.

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Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis

Cited by 3 publications

References 50 publications

HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article

HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article

Prognostic Role of Human Leukocyte Antigen Alleles and Cytokine Single-Nucleotide Polymorphisms in Patients with Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitor Drugs

The association of TNF-α promoter polymorphisms with genetic susceptibility to cervical cancer in a Chinese Han population

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