The wild type alleles at positions 857 and 1031 in the Tumor Necrosis Factor gene promoter are highly conserved among the low/high endemic HBV infected persons in Uganda and may not be attributable to disease burden.
Abstract:Genetic polymorphisms within the gene loci of the promoter region of tumor necrosis factor (TNF) alpha have been associated with the pathogenesis of hepatitis B virus (HBV) infection. Moreover, the prevalence of these polymorphisms varies from individual to individual and are population specific. Thus, we aimed at testing the hypothesis that, TNF-α-863C/A and − 1031T/C polymorphic sites may have an effect on the difference in the burden of HBV in our country. We used a sample of 140 participants from both the … Show more
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