The association between selenium and lipid levels: A longitudinal study in rural elderly Chinese

Chen, Chen; Jin, Yinlong; Unverzagt, Frederick W.; Cheng, Yibin; Hake, Ann Marie; Liang, Chaoke; Ma, Feng; Su, Liqin; Liu, Jingyi; Bian, Jianchao; Li, Ping; Gao, Sujuan

doi:10.1016/j.archger.2014.09.005

Cited by 28 publications

(16 citation statements)

References 36 publications

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“…In this study, no significant differences between males and females in plasma Se concentrations were observed. These findings were in accordance with the majority of data reported in scientific articles describing populations with similar selenium status [ 7 , 22 , 23 , 24 ]. Concerning populations with higher selenium levels, other authors have found significantly higher serum Se concentrations in males when compared to females [ 25 , 26 , 27 ].…”

Section: Discussionsupporting

confidence: 92%

Impact of Selenium Addition to Animal Feeds on Human Selenium Status in Serbia

Pavlović

Miletić²,

Zeković

et al. 2018

Nutrients

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Research conducted during the 1980s demonstrated Se deficiency in humans. Increased inclusion of selenium in animal feeds started from the year 2000 onwards. The aim of this study was to estimate the effects of selenium inclusion in animal feeds on human selenium status and dietary habits of the Serbian population related to food of animal origin. Plasma selenium concentration in healthy adult volunteers, including residents of one of the regions with the lowest (Eastern Serbia, n = 60) and of one of the regions with the highest Se serum levels reported in the past (Belgrade, n = 82), was determined by hydride generation atomic absorption spectrometry. Multivariate analysis was employed to determine the correlation between Se plasma levels and dietary intake data derived from food frequency questionnaires and laboratory tests. The mean plasma Se level of the participants was 84.3 ± 15.9 μg/L (range: 47.3–132.1 μg/L), while 46% of participants had plasma Se levels lower than 80 μg/L. Frequency of meat, egg, and fish consumption was significantly correlated with plasma selenium level (r = 0.437, p = 0.000). Selenium addition to animal feed in the quantity of 0.14 mg/kg contributed to the improvement of human plasma selenium levels by approximately 30 μg/L.

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Section: Discussionsupporting

confidence: 92%

Impact of Selenium Addition to Animal Feeds on Human Selenium Status in Serbia

Pavlović

Miletić²,

Zeković

et al. 2018

Nutrients

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“…Also, the quantile regression models for serum levels of selenium showed a positive association on all the quantiles of serum selenium with increments of participant age, and a stable but stronger association with total serum cholesterol levels persisted at all quantiles of serum selenium (Fig. 4), as some studies suggest [13].…”

Section: Confounding Factors Adjustments With Polynomial Regression Mmentioning

confidence: 61%

“…A recent longitudinal study suggests that selenium may have a harmful role in the development of hypertension in the elderly [12]. High selenium levels have been associated with high serum cholesterol levels [13], and increased risk for diabetes mellitus [14,15]. A previous study on dietary selenium intake in 2638 NHANES participants revealed a positive association of increments in serum selenium and blood pressure in the U.S. population [16].…”

Section: Introductionmentioning

confidence: 99%

Selenium, copper, zinc and hypertension: an analysis of the National Health and Nutrition Examination Survey (2011–2016)

Bastola

Locatis

Maisiak

et al. 2020

BMC Cardiovasc Disord

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Background: Hypertension is a major cardiovascular illness worldwide with many underlying causes. The role of trace elements selenium, copper, and zinc in hypertension is uncertain. The objective of this study was to evaluate the role of these trace elements in hypertension. Method: Data from 6683 National Health and Nutrition Examination Survey (NHANES) participants from 2011 to 2016 were analyzed using Statistical Analytical System (SAS, version 9.4) software for the role of trace elements in hypertension in age range 8 to 80 years, irrespective of the antihypertensive medication taken. Recent American Heart Association guidelines and pediatric practice guidelines for hypertension were used. Results: Findings showed a significant positive association between serum selenium levels and hypertension but not serum zinc and copper. At optimal levels for transport and distribution, serum selenium levels of 120 μg/L or higher (reference level 70-150 μg/L) were significantly associated with hypertension (OR = 1.46, 95% CI = 1.29-1.66) after adjusting for confounding factors. At serum selenium level greater than 150 μg/L, the association with hypertension strengthened (OR = 1.69, 95% CI = 1.32-2.17). Conclusion: A positive association was found between serum selenium and hypertension, irrespective of age or anti-hypertensive medications intake. These findings also suggest that the reference levels of serum levels in healthy individuals may need to be re-determined, if supported by additional studies. If validated, patients with hypertension may also need to be cautioned about selenium intake.

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“…Although there was no heterogeneity among studies used in this meta-analysis on the effect of selenium consumption on TG level, this effect was less than one unit. Only three studies on the effect of selenium on VLDL were eligible for our meta-analysis A 7.5-year study on the rural elderly reported that compared with those in the lowest quintile of serum selenium, the subjects in the highest quartile of selenium had a significant decrease in total TC and TG but an increase in HDL [37].…”

Section: Discussionmentioning

confidence: 99%

Effect of Selenium Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis

et al. 2018

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Selenium is an essential mineral that plays a key role in plenty of major metabolic processes. A growing body of literature has shown that selenium deficiency leads to an increase in plasma TC and TG levels. This study explores the effect of selenium supplementation on serum level of lipid profile [total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low density lipoprotein (VLDL)]. We systematically searched PubMed/MEDLINE, ISI/WOS, and Scopus (from their commencements to Jan 2016) to identify the papers investigating the association between the intake of selenium and lipid profile. Data extracted from the relevant studies were screened. The pooled standardized mean difference was estimated using the random or fixed effects model. Heterogeneity among the studies was assessed using Q-test. Of the potentially relevant articles screened, 11 articles including 1221 participants were included in this meta-analysis. Results of meta-analysis showed that intake of selenium resulted in a statistically significant improvement in TC, [(SMD): –0.13, 95% CI: (–0.24, –0.02)], TG [(SMD): –0.19, 95% CI: (–0.38, –0.01)] and VLDL [(SMD): –0.34, 95% CI: (–0.63, –0.05)]. The selenium supplementation did not significantly improve lipid profile such as LDL [(SMD): –0.08, 95% CI: (–0.036, 0.19)], HDL [(SMD): 0.01, 95% CI: (–0.164, 0.18)], HDL/TC ratio [(SMD): 0.025, 95% CI: (–0.11, 0.16)], non-HDL-C [(SMD): 0.018, 95% CI: (–0.13, 0.16)]. This meta-analysis suggests that the effect of selenium supplementation on the serum levels of TG and VLDL is marginally significant. However, the supplementation has no effect on other serum lipids. Moreover, the study shows that the effect of selenium supplementation on lipid profile is negative.

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The association between selenium and lipid levels: A longitudinal study in rural elderly Chinese

Cited by 28 publications

References 36 publications

Impact of Selenium Addition to Animal Feeds on Human Selenium Status in Serbia

Impact of Selenium Addition to Animal Feeds on Human Selenium Status in Serbia

Selenium, copper, zinc and hypertension: an analysis of the National Health and Nutrition Examination Survey (2011–2016)

Effect of Selenium Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis

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