The association between sarcopenia and non-alcoholic fatty liver disease

Hu, Yibing; Chen, Ze; Fu, Rong-Quan

doi:10.1016/j.jhep.2016.09.023

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…Sarcopenia has become an important concept for understanding the impact of aging on health outcomes. This condition is not only a physiological symptom of aging, but there is growing evidence that low muscle mass is a condition associated with a number of disorders [11][12][13][14][15][16][17]. Sarcopenia is common in elderly populations and contributes to functional limitations, disabilities, and frailty [18,19].…”

Section: Discussionmentioning

confidence: 99%

“…Sarcopenia is common in elderly populations and contributes to functional limitations, disabilities, and frailty [18,19]. Furthermore, several previous studies have found an association with increased risk for several disorders, such as cardiovascular disease, metabolic syndrome, and morbidity or mortality, in individuals with sarcopenia [11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…Sarcopenia is a pathological condition characterized by the progressive loss of muscle mass and increased amount of visceral fat, despite a relatively constant body weight [10]. Recent evidence shows that sarcopenia and sarcopenic obesity are associated with several cardiometabolic diseases, as well as with poor morbidity and mortality outcomes [11][12][13][14][15][16][17]. Reflux esophagitis (RE) and sarcopenia seem to have similar pathophysiologic backgrounds with regard to body composition and metabolic abnormalities.…”

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confidence: 99%

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WITHDRAWN: Sarcopenia as a leading risk factor for erosive esophagitis

Kim¹,

Pyo²,

Lee³

et al. 2018

Oncotarget

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Backgrounds: Obesity is an established risk factor for erosive esophagitis. Yet, the associations of sarcopenia and obesity with erosive esophagitis remain unclear. We studied the associations of obesity, sarcopenia, and sarcopenic obesity with the risk of erosive esophagitis in a large number of asymptomatic men and women. Materials and Methods: We conducted a cross-sectional study of 32,762 asymptomatic adults undergoing routine health checkups including screening endoscopy, between August 2006 and December 2011. Sarcopenia was defined as an appendicular skeletal muscle mass (ASM) /body weight value beyond two standard deviations below the mean for healthy young adults. The ASM was estimated using bioelectrical impedance analysis. Results: Participants were categorized into four groups according to their obesity and sarcopenic status: normal, obese, sarcopenic, and sarcopenic obese. In a multivariable model adjusted for age, sex, smoking status, alcohol intake, regular exercise, and metabolic variables, the risk of erosive esophagitis was higher in obese [adjusted odds ratio(aOR), 1.38; 95% confidence interval (CI), 1.26-1.52], sarcopenic (aOR, 2.20; 95% CI, 1.48-3.29), and sarcopenic obese participants (aOR, 1.68; 95% CI, 1.39-2.03) than in normal participants. Comparing sarcopenic and sarcopenic obese participants to obese participants, the ORs for erosive esophagitis were 1.59 (95% CI, 1.06-2.38) and 1.22 (95% CI, 1.02-1.47), respectively. In dose-response analyses, increasing sarcopenia severity showed a positive and graded relationship with overall, LAB or higher grade, and LA-C erosive esophagitis. Conclusions: Our findings suggest that sarcopenia, regardless of obesity status, is strongly and progressively associated with the risk of erosive esophagitis. IntroductIon Gastroesophageal reflux disease is a widespread gastrointestinal disorder that frequently occurs in primary care settings, imposing considerable burdens on global health and economics [1]. Disease prevalence is 18.1-27.8% in North America, 8.8-25.9% in Europe, and 2.5-7.8% in East Asia, with rising rates worldwide [2]. Obesity is considered a significant contributing factor for a spectrum of reflux-related esophageal disorders ranging from

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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WITHDRAWN: Sarcopenia as a leading risk factor for erosive esophagitis

Kim¹,

Pyo²,

Lee³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Sarcopenia has become an important concept for understanding the impact of aging on health outcomes. This condition is a physiological symptom of aging, and there is growing evidence that low muscle mass is associated with a number of disorders . Sarcopenia is common in elderly populations and contributes to functional limitations, disabilities, and frailty .…”

Section: Discussionmentioning

confidence: 99%

“…Sarcopenia is a pathological condition characterized by the progressive loss of muscle mass and increased amount of visceral fat, despite a relatively constant bodyweight . Recent studies have shown that sarcopenia is associated with several diseases, as well as with poor morbidity and mortality outcomes . The pathophysiological backgrounds of sarcopenia, such as accumulation of visceral fat, metabolic abnormalities, and decreased physical activity, are similar to those of colorectal neoplasia.…”

Section: Introductionmentioning

confidence: 99%

Impact of sarcopenia on the risk of advanced colorectal neoplasia

Hong

Kim

Pyo

et al. 2018

J of Gastro and Hepatol

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Contribution of sarcopenia and physical inactivity to mortality in people with non-alcoholic fatty liver disease

et al. 2020

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Non-alcoholic fatty liver disease (NAFLD) and sarcopenia have similar pathophysiological profiles. In our study, amongst NAFLD patients, sarcopenia was inversely related to increased physical activity level. The presence of sarcopenia in patients with NAFLD poses increased risk for all-cause and cardiacspecific mortality. Lay summary Nonalcoholic fatty liver disease (NAFLD) and sarcopenia have similar pathophysiological profiles. Our data show that sarcopenia is associated with inactivity in subjects with NAFLD. The presence of sarcopenia in patients with NAFLD poses increased risk for all-cause and cardiac-specific mortality.

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The association between sarcopenia and non-alcoholic fatty liver disease

Cited by 5 publications

References 10 publications

WITHDRAWN: Sarcopenia as a leading risk factor for erosive esophagitis

WITHDRAWN: Sarcopenia as a leading risk factor for erosive esophagitis

Impact of sarcopenia on the risk of advanced colorectal neoplasia

Contribution of sarcopenia and physical inactivity to mortality in people with non-alcoholic fatty liver disease

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