Impact of sarcopenia on the risk of advanced colorectal neoplasia

Hong, Ji Taek; Kim, Tae Jun; Pyo, Jeung Hui; Kim, Eun Ran; Hong, Sung Noh; Kim, Young‐Ho; Ahn, Hyeon Seon; Sohn, Insuk; Chang, Dong Kyung

doi:10.1111/jgh.14309

Cited by 15 publications

(17 citation statements)

References 49 publications

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“…Furthermore, other previous studies have demonstrated that sarcopenia is associated with adverse postoperative outcomes and poor overall survival in patients with CRC . In addition, the presence of patients with sarcopenia is inversely related to the expense of hospital care, and is associated with advanced colorectal neoplasia and increased postoperative inflammatory response in patients with CRC .…”

Section: Discussionmentioning

confidence: 99%

A new diagnostic index for sarcopenia and its association with short‐term postoperative complications in patients undergoing surgery for colorectal cancer

et al. 2019

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Aim Sarcopenia is a robust prognostic indicator of outcomes after surgery for colorectal cancer (CRC). However, there are no serum markers routinely available for estimating skeletal muscle mass (SMM). The present study aimed to describe a new sarcopenia index (SI), serum creatinine (Scr) 9 cystatin C-based glomerular filtration rate, and investigate its association with shortterm complications after curative resection of CRC.Method Consecutive patients who underwent curative resection of CRC from December 2011 to January 2017 were retrospectively identified. Skeletal muscle cross-sectional area was analysed on L3 computed tomographic images. Receiver operating characteristic curve analysis showed that the cutoff points of SI for sarcopenia were below 56.1 in men and below 43.7 in women. Patients were classified into low and high SI groups in accordance with these cutoff values. The association between SI and body composition and the impact of preoperative SI on postoperative outcomes were analysed.Results Among 417 patients, SI showed a stronger correlation with skeletal muscle area (SMA) (r = 0.537, P < 0.001) than with the Scr/cystatin C ratio (r = 0.469, P < 0.001) and Scr (r = 0.447, P < 0.001). The low SI group had a lower SMA, lower preoperative haemoglobin, a higher prevalence of sarcopenia and experienced more postoperative complications compared with the high SI group (all P < 0.001). Multivariate logistic regression analysis showed that the independent risk factors for overall complications were low preoperative haemoglobin, low SI, sarcopenia and American Society of Anesthesiologists grade ≥ 3.Conclusion This new SI is a simple and useful surrogate marker for estimating SMM, and is associated with outcomes after CRC surgery.What does this paper add to the literature? We describe a novel, simple approach with which to diagnose sarcopenia. The new sarcopenia index (SI), serum creatinine 9 cystatin C-based glomerular filtration rate, is closely associated with skeletal muscle mass. A low SI is an independent risk factor for postoperative complications after curative resection of colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

A new diagnostic index for sarcopenia and its association with short‐term postoperative complications in patients undergoing surgery for colorectal cancer

et al. 2019

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“…[16] In another study in which muscle mass measured by BIA in adults aged ≥50 years was corrected by weight, and sarcopenia was categorized into classes I and II according to severity, class I sarcopenia increased the risk for developing advanced colorectal neoplasia (adenoma >1 cm in size, any adenoma containing a villous component, high-grade dysplasia, or invasive colorectal cancer) by 1.14 and 1.5 times compared to class II sarcopenia. [17]…”

Section: Discussionmentioning

confidence: 99%

Association between Colorectal Adenoma and Hand Grip Strength in the Elderly

Kim

Kong

et al. 2019

J Bone Metab

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Background: Obesity is known as an important risk factor for colorectal adenoma. However, for the elderly with changes in body composition, reduced muscle, and increased fat, the body mass index (BMI), one of the most commonly used indicators of obesity, is limited in predicting a link to colorectal cancer. This study aimed to investigate the relationship between colorectal adenoma and grip strength that can predict muscle reduction in the elderly. Methods: This study included 262 participants aged ≥65 years who underwent medical examination between June 2015 and August 2018. The control group comprised participants with normal findings or hyperplasia and other benign lesions, except adenoma on colonoscopy, whereas the adenoma group consisted of participants with more than one adenoma. Grip strength was alternately measured twice for each hand using a hydraulic dynamometer. Results: The grip strength was statistically lower in the adenoma group than in the control group among women (P=0.042). For both sexes, grip strength was significantly lower in participants with ≥5 adenomas than in those with <5 adenomas (P=0.021, P=0.007). Similarly, men with large adenomas (≥7 mm) exhibited significantly lower grip strength than did those with small adenomas (<7 mm) (P=0.004). Even after correction for age, BMI, smoking status, alcohol consumption, exercise, insulin resistance, hypertension, and diabetes, the negative correlation between grip strength and number of adenomas among men and women remained (P=0.034, P=0.019). Conclusions: A significant relationship between hand grip strength and number of colorectal adenomas was noted.

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“…Additionally, visceral adipose tissue may serve as a more accurate marker than the waist circumference for assessing increased CRC risk. Comparing participants with sarcopenia to those without sarcopenia, the odds ratio (95% confidence interval) was found to be 1.99 (1.63-2.43) for advanced CRC patients [16]. Lieffers et al [13] reported that sarcopenia is associated with postoperative infections and inpatient rehabilitation care, consequently resulting in a prolonged hospital stay.…”

Section: Discussionmentioning

confidence: 99%

Association between body composition measured by bioelectrical impedance analysis and platelet-to-lymphocyte ratio in colorectal cancer

Song

Kim

Bae

et al. 2019

Korean J Clin Oncol

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Impact of sarcopenia on the risk of advanced colorectal neoplasia

Abstract: Our findings indicate that sarcopenia is significantly and progressively associated with the risk of advanced colorectal neoplasia. This association might be explained by metabolic factors that could be potential mediators of the effect of sarcopenia.

Cited by 15 publications

References 49 publications

A new diagnostic index for sarcopenia and its association with short‐term postoperative complications in patients undergoing surgery for colorectal cancer

A new diagnostic index for sarcopenia and its association with short‐term postoperative complications in patients undergoing surgery for colorectal cancer

Association between Colorectal Adenoma and Hand Grip Strength in the Elderly

Association between body composition measured by bioelectrical impedance analysis and platelet-to-lymphocyte ratio in colorectal cancer

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