The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

Abstract

Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control studies to assess the association between PON1 (Q192R and L55M) gene polymorphisms and risk of cancer. With the STATA 14.0 software, we evaluated the strength of the association by using the odds ratios (ORs) and 95% confidence intervals (CIs). A total of 43 case-control publications 19887 cases and 23842 controls were employed in our study. In all genetic models, a significant association between PON1-L55M polymorphisms and overall cancer risk was observed. Moreover, in the stratified analyses by cancer type, polymorphism of PON1-L55M played a risk factor in the occurrence of breast cancer, hematologic cancer, and prostate cancer. Similarly, an increased risk was observed in the Caucasian and Asian population as well as hospital-based group and population-based group. For PON1-Q192R polymorphisms, in the stratified analyses by cancer type, PON1-Q192R allele was associated with reduced cancer risks in breast cancer. Furthermore, for racial stratification, there was a reduced risk of cancer in recession model in Caucasian population. Similarly, in the stratification analysis of control source, the overall risk of cancer was reduced in the heterozygote comparison and dominant model in the population-based group. In conclusion, PON1-Q192R allele decreased the cancer risk especially breast cancer; there was an association between PON1-L55M allele and increased overall cancer risk. However, we need a larger sample size, well-designed in future and at protein levels to confirm these findings.

Association of PON1, LEP and LEPR Polymorphisms with Susceptibility to Breast Cancer: A Meta-Analysis

“…Their results showed that PON1 rs854560 genetic polymorphisms may be associated with the risk of BC. However, they have Pan et al, (2019) in meta-analysis reported that the PON1 rs662 is associated with decrease of breast cancer risk. Their results showed an increased risk in the Caucasian and Asian population as well as HB group and PB group.…”

A systematic review: breast cancer susceptibility genes

“…In a meta-analysis based on 43 studies, PON1-L55M was found to be a risk factor in the genesis of breast cancer in the Caucasian and Asian population (OR = 2.19). Meanwhile, PON1-Q192R polymorphisms correlated with the decreased risk in breast cancer in the same population as above (OR = 0.64) [37].…”

Anti-leukemogenic Efficacy of Aloe vera Gel on Benzene-induced Leukemia in Wistar Rats

“…Decreased serum activity of PON1 has been reported in some cancer patients [64]. The polymorphism of PON1 gene has been used as a prediction for cancer susceptibility due to its ability to detoxify the products of oxidative stress [65] and considered a risk factor for the occurrence of certain cancer types like breast, prostate and hematologic cancers [66]. In the present study, there was a significant reduction in the plasma activity of arylesterase in the leukemic rats which may be due to overwhelming pro-oxidant effect of benzene intoxication leading to oxidative stress condition.…”