Association of PON1, LEP and LEPR Polymorphisms with Susceptibility to Breast Cancer: A Meta-Analysis

Abstract

Objective: Breast cancer is the most common cancer in American women, except for skin cancers. In this metaanalysis, the associations of polymorphisms within paraoxonase 1 (PON1), leptin (LEP) and leptin receptor (LEPR) genes with susceptibility to breast cancer were comprehensively evaluated. Methods: A universal search in PubMed, Scopus, CNKI, SID, Web of Knowledge and Google Scholar was performed to identify relevant studies up to 01 May, 2021. The strength of the associations was estimated by Odds ratios (ORs) with 95% confidence intervals (95% CIs). Results: A total of 39 case-control studies including 7 studies with 2005 cases and 2748 controls were on PON1 rs662, 6 studies with 2,031 cases and 1,973 controls on PON1 rs854560, 12 studies with 3,444 cases and 3,583 controls on LEP rs7799039, and 14 studies with 5,330 cases and 6,188 controls on LEPR rs1137101 were selected. Pooled data showed that PON1 rs662 and rs854560 polymorphisms were associated with risk of breast cancer in overall population, but not LEP rs7799039 and LEPR rs1137101. Conclusions: Our pooled data revealed that the PON1 rs662 and rs854560 polymorphisms were significantly associated with an increased risk of breast cancer in the overall population. However, LEP rs7799039 and LEPR rs1137101 polymorphisms were not associated.

Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: A systematic review and meta-analysis

“…The current study contains more casecontrol studies with larger sample, making our results should be more reliable. It is worth mentioning that the results of a metaanalysis by Sayad et al 42 with only 14 case-control studies for Q223R published in 2021 were similar to ours. Our data also suggested that GG genotype of K109R in Asian population may also protect against BC, while AG genotype of K109R in Asian population may confer elevated susceptibility of BC.…”

Genetic alterations in LEP and ADIPOQ genes and risk for breast cancer: a meta-analysis

“…Our findings supported this hypothesis by showing that LEP gene rs7799039 and ADIPOQ gene rs1501299 were two promising breast cancersusceptibility loci. By contrast, a recent meta-analysis by Sayad and coworkers did not support the association of LEP gene rs7799039 and LEPR gene rs1137100 with breast cancer (54). It is possibly because of the differing number of eligible studies involved between the meta-analysis by Sayad and coworkers (54) and the present meta-analysis.…”

“…By contrast, a recent meta-analysis by Sayad and coworkers did not support the association of LEP gene rs7799039 and LEPR gene rs1137100 with breast cancer (54). It is possibly because of the differing number of eligible studies involved between the meta-analysis by Sayad and coworkers (54) and the present meta-analysis. As far as we know, we, for the first time, meta-analyzed the association between ADIPOQ gene and breast cancer.…”

Association of the CXCL12 rs1801157 Polymorphism with Breast Cancer Risk: A Meta-Analysis

“…An estimated 287,850 new cases women were diagnosed with breast cancer in USA and 43,250 women will die from breast cancer in 2022 [ 4 , 5 ]. The occurrence of breast cancer is associated with many risk factors, including genetic and hereditary predisposition [ 6 , 7 ]. Breast cancers are highly heterogeneous [ 8 , 9 ].…”