Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: A systematic review and meta-analysis

Abstract

Background: Increasing evidence has suggested a strong association of Q223R (rs1137101) and K109R (rs1137100) polymorphisms in leptin receptor (LEPR) gene with susceptibility of breast cancer (BC), but inconsistent results were obtained. To provide a quantitative assessment of this association, a systematic review and meta-analysis was performed. Methods: A literature search of PubMed, EMBASE, Google Scholar, and the Chinese National Knowledge Infrastructure was collected. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results: A total of 20 case-control studies for Q223R polymorphism and 8 case-control studies for K109R polymorphism were included. Significant association between Q223R polymorphism and BC risk was not found in total, Asian or Caucasian population, but

The 2022 Journal of Chinese Medical Association Award-Winning Research Illuminates the Promise of Integrating Acupuncture and Related Techniques in Rheumatoid Arthritis Treatment

“…Their methodology and transparent reporting lend further credibility to their study, making it a valuable reference for future research. [12][13][14][15] However, it is crucial to note that the discussion of results and the inclusive references should be appropriately positioned within the discussion section rather than being confined to the results section.…”