The Association between Nocturia and Nocturnal Polyuria in Clinical and Epidemiological Studies: A Systematic Review and Meta-Analyses

Hofmeester, Ilse; Kollen, Boudewijn J.; Steffens, M.G.; Bosch, Jackie; Drake, Marcus; Weiss, Jeffrey P.; Blanker, Marco H.

doi:10.1016/j.juro.2013.10.100

Cited by 47 publications

(51 citation statements)

References 26 publications

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“…One major contributor to nocturia in aged people is a nocturnal overproduction of urine [3, 5, 7, 14]. However, nocturnal polyuria is present even in patients without nocturia [11].…”

Section: Discussionmentioning

confidence: 99%

Lack of Change in the Adaptation Ability of the Bladder for the Urine Production Rate in Aged Men with Nocturia

Kira¹,

Mitsui²,

Miyamoto³

et al. 2018

Urol Int

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Introduction: To investigate the association between bladder capacity and the urine production rate in aged men with or without nocturia using a frequency volume chart (FVC). Materials and Methods: One-hundred and thirty-eight men aged 65–80 years were enrolled. After the International Prostate Symptom Score (IPSS) and 3 consecutive days FVC were evaluated, men were divided into 2 groups: Nocturia group, with any total IPSS, and ≥1.5 micturition on average at night; and Control group, with total IPSS < 8 and < 1.5 micturition on average at night. Each parameter was compared between the 2 groups using unpaired t tests. Linear and multiple regression analyses were performed between the urine production rate and volume/voids. Results: Men numbering 45 and 21 were assigned to the Nocturia and Control groups respectively. There were no differences in background factors between the 2 groups. Volume/voids positively correlated with the urine production rate in both groups for day and night. A multivariate regression model also showed the same results. In the Control group, the degree of slope at night was higher than that during the day. However, in the Nocturia group, there were no differences in the degree of slope between day and night. Conclusions: This novel finding has led to a possibility for resolving nocturia.

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“…One major contributor to nocturia in aged people is a nocturnal overproduction of urine [3, 5, 7, 14]. However, nocturnal polyuria is present even in patients without nocturia [11].…”

Section: Discussionmentioning

confidence: 99%

Lack of Change in the Adaptation Ability of the Bladder for the Urine Production Rate in Aged Men with Nocturia

Kira¹,

Mitsui²,

Miyamoto³

et al. 2018

Urol Int

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“…Second, we used both the internationally standardized definition of NP as well as an alternative one; both yielded the same results. We did not use other possible definitions of NP, for example nocturnal urine production (NUP) > 90 ml/hour, or nocturia index > 1 13 since each has limitations. For instance, the NUP criterion ignores urine production during the day and presumes that urine output is constant between 1 am–6 am.…”

Section: Discussionmentioning

confidence: 99%

“…To categorize the participants with NP we not only used the ICS definition of NPi of >33%, 2 but also an alternative threshold of NPi of > 53%. 13 Participants with a 24-hour urine volume >40 ml/kg body-weight were classified as having 24-hour polyuria. 2 Time in bed was defined as the interval between going to bed with the intent of sleeping and getting up for the day, and it was obtained using the times recorded in the 3-day bladder diary.…”

Section: Methodsmentioning

confidence: 99%

Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used

et al. 2017

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Purpose Nocturia is common and bothersome in older adults especially those who are also incontinent. Since nocturnal polyuria (NP) is a major contributor, we examined factors associated with NP in this population to identify those possibly amenable to intervention. Method We analyzed baseline data from two previously-completed studies of urge urinary incontinence (UUI). The studies involved 284 women (mean 72.9 ±7.9 years) who also completed 3-day voiding diaries. Participants with nocturnal polyuria index (NPi) of > 33% were categorized as having NP (NPi= nocturnal urinary volume/24-hour urine volume). Associations between NP and various demographic, clinical, and sleep-related parameters were determined. Results Fifty-five percent of the participants had NP. Multivariable regression analysis revealed that age, body mass index (BMI), use of angiotensin-converting-enzyme inhibitor (ACE-I)/angiotensin receptor blocker (ARB), time spent in bed, and duration of first uninterrupted sleep (DUS) were independent correlates of NP. Participants with larger nocturnal excretion reported shorter DUS and worse sleep quality despite spending similar time in bed. Conclusion BMI, use of ACE-I/ARB, time in bed and DUS are independently associated with NP in older women with UUI, and are potentially modifiable. These findings also confirm the association between sleep and NP. Further studies should explore whether interventions to reduce NP and/or increase DUS help to improve sleep quality in this population and thereby reduce or eliminate the need for sedative hypnotics.

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“…Therefore, our findings bolster the growing body of evidence suggesting that nocturnal polyuria and reduced bladder capacity may function as major contributors to the clinical symptom of nocturia. [23][24][25][26] Despite the evidence suggesting an association between DM or hypertension and nocturia, 4-12,14,15 our analysis failed to demonstrate a significant difference in nocturia severity based on DM or hypertension status. However, those investigators who have demonstrated an association between nocturia and DM or hypertension must consider elderly status as a potential confounding factor.…”

Section: Resultsmentioning

confidence: 67%

Prediction of Nocturia Severity in Men

et al. 2015

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The Association between Nocturia and Nocturnal Polyuria in Clinical and Epidemiological Studies: A Systematic Review and Meta-Analyses

Cited by 47 publications

References 26 publications

Lack of Change in the Adaptation Ability of the Bladder for the Urine Production Rate in Aged Men with Nocturia

Lack of Change in the Adaptation Ability of the Bladder for the Urine Production Rate in Aged Men with Nocturia

Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used

Prediction of Nocturia Severity in Men

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