Abstract:Neither race nor metabolic risk factors affect nocturia severity. In contrast, variables that denote nocturnal urine overproduction sharply discriminate the risk of nocturia severity and suggest that variable data may provide useful clinical correlation.
“…Prior studies have found significantly increased risks for LUTS in Hispanic/Latino and African American descent adults regardless of gender or comorbidities. 26–29 This association has not been previously noted in pediatric children.…”
Lower urinary tract symptoms (LUTS) are an underrecognized complication of diabetes mellitus (DM) in adults and have undergone limited investigation in children. We estimated the prevalence of LUTS in 120 older children (11-17 years) with and without DM and identified patient factors associated with LUTS in logistic regression. Older children (11-17 years) completed a validated LUTS measure and questions about age, ethnicity, gender, body mass index, and degree of bother secondary to LUTS. The unadjusted prevalence of LUTS was 20.87% in the overall cohort, and LUTS was twice as prevalent in children with DM (33.3% vs 16.7%) than children without DM. In logistic regression, Hispanic/Latino ethnicity was positively associated with LUTS (odds ratio = 8.45, P = .011). LUTS may be a prevalent but underrecognized condition, which is more prevalent in Hispanic/Latino and diabetic children.
“…Prior studies have found significantly increased risks for LUTS in Hispanic/Latino and African American descent adults regardless of gender or comorbidities. 26–29 This association has not been previously noted in pediatric children.…”
Lower urinary tract symptoms (LUTS) are an underrecognized complication of diabetes mellitus (DM) in adults and have undergone limited investigation in children. We estimated the prevalence of LUTS in 120 older children (11-17 years) with and without DM and identified patient factors associated with LUTS in logistic regression. Older children (11-17 years) completed a validated LUTS measure and questions about age, ethnicity, gender, body mass index, and degree of bother secondary to LUTS. The unadjusted prevalence of LUTS was 20.87% in the overall cohort, and LUTS was twice as prevalent in children with DM (33.3% vs 16.7%) than children without DM. In logistic regression, Hispanic/Latino ethnicity was positively associated with LUTS (odds ratio = 8.45, P = .011). LUTS may be a prevalent but underrecognized condition, which is more prevalent in Hispanic/Latino and diabetic children.
Aims
To test the hypothesis that patients with nocturia owing to diminished global or nocturnal bladder capacity improve via increased bladder capacity.
Methods
This is a retrospective analysis of voiding diaries completed at a VA urology clinic between 2008–2017. Inclusion required patients aged at least 18 years, male, undergoing treatment for nocturia, and having completed at least two 24‐hour voiding diaries ≥1 month apart. Patients were divided into two cohorts: responders (any decline in nocturia) and non‐responders (no change or any increase in nocturia). Patients were further sub‐stratified as having low global bladder capacity (maximum voided volume [MVV] <200 mL) versus low nocturnal bladder capacity (nocturnal maximum voided volume [NMVV] <200 mL and MVV ≥200 mL). Wilcoxon rank‐sum was applied with a Bonferroni correction to test significance.
Results
Forty pre‐ and post‐treatment diaries from 27 patients, and 19 pre‐ and post‐treatment diaries from 17 patients were identified as having low global and low nocturnal bladder capacity, respectively. Nocturia responders with low global bladder capacity demonstrated significant decline compared to non‐responders in nocturnal urine volume (NUV) (−140 vs +75, P < 0.01) and nocturnal bladder capacity index (NBCi) (−0.59 vs +0.23, P < 0.01). Patients with low nocturnal bladder capacity similarly demonstrated decreased NUV (−30 vs +160, P = 0.04) and NBCi (−1.4 vs +0.33, P < 0.01). There was no significant change in MVV or NMVV for either group.
Conclusions
Treatment directed at lowering nocturnal urine production and enabling patients to consistently void at capacity is a rational strategy to treat nocturia in patients with low bladder capacity.
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