The association between high oral intake of acrylamide and risk of breast cancer: An updated systematic review and meta-analysis

Atabati, Hadi; Abouhamzeh, Beheshteh; Abdollahifar, Mohammad‐Amin; Javadinia, Sara Sadat; Bajestani, Saeed Gharibian; Atamaleki, Ali; Raoofi, Amir; Fakhri, Yadolah; Oliveira, Carlos Augusto Fernandes de; Khaneghah, Amin Mousavi

doi:10.1016/j.tifs.2020.04.006

Cited by 16 publications

(4 citation statements)

References 46 publications

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“…This study was performed for assessing documents relating to the concentration of PTEs (As, Cd, Pb, Ni and Hg) in coastal sediment of the Persian Gulf following PRISMA guidelines (Fig. 1) (Atabati et al 2020, Moher et al 2011). All published investigations in the English language were searched in international databases including Web of Science, Scopus, Embase, and PubMed as well as Google Scholar (grey literature) from 1 January 2010 to 10 September 2022.…”

Section: The Protocol and Search Strategymentioning

confidence: 99%

Potential toxic elements (PTEs) in costal sediment of the Persian Gulf: A systematic review-meta-analysis, non-dietary risk Assessment and ecological risk assessment

Hui

Asadi

Fakhri

et al. 2022

Preprint

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Chemical pollution in the Persian Gulf has become an important health concern in recent decades. This investigation aimed to meta-analyses of potential toxic elements (PTEs) including lead (Pb), inorganic Arsenic (As), Cadmium (Cd), Nickel (Ni) and Mercury (Hg) in the coastal sediment of the Persian Gulf. In this study, an attempt was made to retrieve papers conducted on the concentration of PTEs in the coastal sediment of the Persian Gulf by searching in international databases including Web of Science, Scopus, Embase and PubMed. Meta-analysis concentration of PTEs in the coastal sediment of the Persian Gulf was conducted using random effects model based on the country subgroup. Additionally, non-dietary risk assessment including non-carcinogenic and carcinogenic risks from ingestion, inhalation and dermal contact routes and ecological risk assessment was estimated. Seventy-eight papers with 81 data-reports (1650 sample size) were included in our meta-analysis. The rank order of heavy metals in coastal sediment of the Persian Gulf based on pooled concentration was Ni (65.44 mg/kg) > Pb (58.35 mg/kg) > As (23.78 mg/kg) > Cd (1.75 mg/kg) > Hg (0.77 mg/kg). The highest concentration of As, Cd, Pb, Ni and Hg was observed in the coastal sediment of Saudi Arabia, Arab Emirates, Qatar, Iran and Saudi Arabia, respectively. Although the Igeo index in coastal sediment of the Persian gulf was in Grade 1 (Uncontaminated) and grade 2 (slightly contaminated) but total target hazard quotient (TTHQ) of adults due to As and Cd and Adolescent due to As, Cd, Pb and Niwas higher than 1 value In Iran, In Saudi Arabic, TTHQ of adults due to As and Cd and adolescent due to As and Cd was higher than 1 value, In United Arab Emirates, TTHQ of adults due to Cd and Adolescents due to As, Cd and Pb were higher than 1 value and In Qatar, TTHQ of adults age group due to Pb and adolescent age group due to Pb was higher than 1 value. Total cancer risk (TCR) for adults and adolescent due to As was higher than 1E-6 in Iran, United Arab Emirates and Qatar but TCR for adolescents due to As was higher than 1E-6 in Saudi Arabic. Therefore, it is recommended to monitor the concentration of PTEs and implementation of programs to reduce the emission of PTEs from resources in the Persian Gulf.

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Section: The Protocol and Search Strategymentioning

confidence: 99%

Potential toxic elements (PTEs) in costal sediment of the Persian Gulf: A systematic review-meta-analysis, non-dietary risk Assessment and ecological risk assessment

Hui

Asadi

Fakhri

et al. 2022

Preprint

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“…In the present study, the bibliography search was done according to the Cochrane's protocol (31,32) among some of the international databases such as Scopus, Medline, and Embase between May 1, 1977 and February 1, 2020 on the global scale. In this regard, the comprehensive searching was done in four steps: Identification, screening, eligibility, and finally, including articles based on PRISMA guideline shown in Figure 1 (33).…”

Section: Search Strategymentioning

confidence: 99%

Global evaluation of potentially harmful elements (PHEs) in potato and carrot irrigated by wastewater: A systematic review, meta-analysis, and health risk assessment

Karimi

Yazdanbakhsh

Atamaleki

et al. 2021

Environ Health Eng Manag

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Background: We aimed to conduct a meta-analysis on the concentration of potentially harmful elements (PHEs) in carrots and potatoes irrigated by wastewater and estimate non-carcinogenic health risks among adult and children consumers. Methods: The health risk of PHEs concentration, including Pb, Cd, total Cr, Ni, Zn, Cu, and Fe, in the edible parts of carrot and potato irrigated by wastewater was investigated by a meta-analysis using a random-effects model (REM). Accordingly, the related articles were screened from international databases such as Scopus, Medline, and Embase. Results: The meta-analysis of 32 papers (38 studies) revealed that the rank order of the most accumulated PHEs in potato was Fe (86.54 mg/kg wet weight) > Zn (30.9 mg/kg wet weight) > Cu (13.7 mg/kg wet weight) > Ni (8.42 mg/kg wet weight) > Pb (5.56 mg/kg wet weight) > Cr (3.45 mg/kg wet weight) > Cd (0.58 mg/kg wet weight). This ranking for carrot was Fe (43.36 mg/kg wet weight) > Zn (36.29 mg/kg wet weight) > Ni (13.49 mg/kg wet weight) > Cu (9.79 mg/kg wet weight) > Pb (1.84 mg/kg wet weight) > Cr (1.05 mg/kg wet weight) > Cd (0.28 mg/kg wet weight). Total hazard quotient (THQ) of PHEs was higher than 1 for potato and carrot; its rank order for potato and carrot was Cu > Pb > Cd > Ni > Fe > Zn > Cr and Cd > Pb > Cu > Ni > Fe > Zn > Cr, respectively. The Cd, Pb, and Cu had also a considerable role for consumer health risk. Conclusion: According to the results, continuous monitor and control of wastewater treatment plants are necessary.

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“…Previous papers stated that acrylamide exposure is associated with unfavorable outcomes such as neurotoxicity, cardiotoxicity, and cancer formation [5][6][7]. However, the exact mechanism of these associations is not entirely clear; experiments point out that acrylamide causes the overproduction of Reactive Oxygen Species (ROS), leading to Lipid Peroxidation (LPO) and oxidative stress, which play an important role in the pathogenesis of toxicity [8].…”

Section: Introductionmentioning

confidence: 99%

The preventive effect of taxifolin on acrylamide-induced heart damage in rats

Coşgun

Coskun

Çelik³

2022

Rev. Nutr.

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Objective Acrylamide is a toxic compound widely used in industrial sectors. Acrylamide causes reactive oxygen species formation and the subsequent lipid peroxidation reaction, which plays an important role in the pathogenesis of oxidative damage. Taxifolin is a flavonoid with antioxidant properties that inhibit reactive oxygen species formation. In this study, we aimed to investigate the preventive effect of taxifolin on acrylamide-induced oxidative heart damage. Methods The rats were divided into three groups: Acrylamide, Acrylamide+Taxifolin , and Healthy group. Water and food intake and body weight alterations were recorded daily. Malondialdehyde, total glutathione, nuclear factor kappa-B, total oxidant status, and total antioxidant status levels were analyzed from the heart tissue. Troponin-I levels, the parameter known as a cardiac biomarker, were analyzed from the blood sample. The cardiac histopathologic examination was also performed. Results In the Acrylamide group animals, the malondialdehyde, nuclear factor kappa-B, total oxidant status, and troponin-I levels were significantly higher compared to the ones of Acrylamide+Taxifolin and Healthy groups. The levels of total glutathione and total antioxidant status were significantly lower compared to Acrylamide+Taxifolin and Healthy groups’. Additionally, in the Acrylamide group, body weight gain, food and water intake, significantly declined compared to the Acrylamide+Taxifolin and Healthy groups. However, in the Acrylamide+Taxifolin group, taxifolin supplementation brought these values close to Healthy group ones. Furthermore, taxifolin treatment ameliorated structural myocardial damage signs induced by acrylamide. Conclusion Acrylamide exposure significantly induced oxidative damage to rat heart tissue. Taxifolin was able to improve the toxic consequences of acrylamide biochemically and histopathologically, possibly due to its antioxidant properties.

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The association between high oral intake of acrylamide and risk of breast cancer: An updated systematic review and meta-analysis

Cited by 16 publications

References 46 publications

Potential toxic elements (PTEs) in costal sediment of the Persian Gulf: A systematic review-meta-analysis, non-dietary risk Assessment and ecological risk assessment

Potential toxic elements (PTEs) in costal sediment of the Persian Gulf: A systematic review-meta-analysis, non-dietary risk Assessment and ecological risk assessment

Global evaluation of potentially harmful elements (PHEs) in potato and carrot irrigated by wastewater: A systematic review, meta-analysis, and health risk assessment

The preventive effect of taxifolin on acrylamide-induced heart damage in rats

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