The Association Between Current Helicobacter pylori Infection and Coronary Artery Disease

Abstract

Background : The role of Helicobacter pylori (H. pylori) in the pathogenesis of coronary artery disease (CAD) is still controversial, and the relation between current H. pylori infection and CAD has not been fully examined. This study evaluated the relation between H. pylori infection as confirmed by gastroduodenoscopic biopsy and CAD.Methods : We determined the presence of H. pylori infections, via gastroduodenoscopy, in 88 patients of the normal coronary angiographic group and also in 175 patients of the CAD group, and the latter patients had more than 50% coronary stenosis angiographically demonstrated. We excluded those patients with a history of previous H. pylori eradication and/or malignancy. A small piece of tissue from the antrum, which was obtained by gastroduodenoscopic biopsy, was stained by Warthin-starry silver stain. We defined a negative staining result that there was no stained tissue in the sample and the stained tissue was also positive for H. pylori infection.Results : There was no significant difference, except for gender, age, smoking and high density lipoprotein cholesterol (HDL-c), of the demographic and laboratory characteristics between the groups. Twenty seven (30.7%) patients of the normal control group and 71 (40.6%) patients of the CAD group were positive of H. pylori infection, yet there was no statistical difference. We angiographically followed up the 80 patients of the CAD group who were treated by percutaneous coronary intervention (PCI) at 6 to 9 months after their primary intervention. Twenty two (37.9%) of the 58 patients of the H. pylori negative group and 10 (45.5%) of the 22 patients of the H. pylori positive group were treated with reintervention, but reintervention was also not significantly different between the group with H. pylori infection and the group without the infection.Conclusions : These data indicated that H. pylori infection had a modest influence on CAD and progressive atheroma, but the showed a tendency to increase. Further studies are needed to evaluate the relationship between H. pylori infection and CAD.

Helicobacter pylori Infection is Associated with Elevated Low Density Lipoprotein Cholesterol Levels in Elderly Koreans

“…A number of previous studies have suggested that mild systemic inflammation provoked by H. pylori infection is associated with metabolic syndrome and atherosclerotic cardiovascular disease (2-6). However, some studies could not confirm this association (7-9).…”

Association ofHelicobacter pyloriInfection with Coronary Artery Disease: IsHelicobacter pyloria Risk Factor?

“…On the contrary, some studies did not show any association between HP and CAD [14, 15]. It is assumed that an undetected chronic infection may be behind these changes in inflammatory markers and highlights microorganisms that are commonly detectable in asymptomatic individuals.…”

Scintigraphic evaluation of gallbladder motor functions in H pylori positive and negative patients in the stomach with dyspepsia

“…Dental disease might be associated with a higher recurrence of H pylori infection [9] . Some investigators have recently demonstrated the evidences that H pylori infection induced atherosclerosis and that H pylori-anti-heat-shock protein antibodies have been related to the prevalence of diseases such as coronary artery disease or cerebral infarction, resulted from atherosclerosis [10,11] . The H pylori may play a role in the pathogenesis of slow coronary flow via the elevation of homocysteine, and/or a possible disturbance in its metabolism [12] .…”

“…The H pylori colonizing on the surface of the upper gastrointestinal mucosa is an interesting cause of active chronic gastritis and duodenitis or even gastric cancer worldwide [2][3][4][5][6][7] . The presence of H pylori infection could predispose to various disorders [8][9][10][11][12][13][14] . Dental disease might be associated with a higher recurrence of H pylori infection [9] .…”