Association ofHelicobacter pyloriInfection with Coronary Artery Disease: IsHelicobacter pyloria Risk Factor?

Abstract

Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiography. The coronary angiography was performed using Judkins method and patients were assigned to participate in CAD positive (>50% luminal diameter stenosis) and negative groups. The serum HP IgG antibody was checked. Results. Positive and negative CAD groups consisted of 62 and 58 patients, respectively. HP was more prevalent among CAD+ patients, and with increasing the number of coronary arteries with stenosis, the HP seropositivity increased so that 76.3% of patients with multiple vessel diseases (MVD) and 70% of patients with single vessel diseases (SVD) were HP seropositive versus 50% in control group (P = 0.006). Positive CAD was significantly associated with HDL level (P = 0.01) and ESR level (P = 0.006). Also, CAD+ patients had higher CRP levels than controls and it was statistically different between SVD group and controls (P < 0.05). Conclusion. HP infection is more prevalent in CAD positive patients and, in case of proving causal relationship, it can be considered as a reversible risk factor for CAD.

Structural and functional characterization of the <em>Helicobacter pylori </em>cytidine 5&#39;-monophosphate-pseudaminic acid synthase PseF: molecular insight into substrate recognition and catalysis mechanism

“…More than half of the global population is infected with H. pylori 12–6 and other extra-gastrointestinal diseases,7 including iron-deficiency anemia,8 idiopathic thrombocytopenic purpura,9 cardiovascular diseases,10 liver illness,11 pancreatic cancer,12 respiratory illness,13 skin diseases14 and diabetes 15. This is the first bacterium to be classified as a definitive human carcinogen by the International Agency for Research on Cancer 16.…”

Helicobacter pyloriInfection and Insulin Resistance in Diabetic and Nondiabetic Population

“…The mononuclear infiltration is characterized by the local production and systemic diffusion of proinflammatory cytokines affecting remote tissues and organic systems [3, 4]. This systemic inflammation causes some extragastrointestinal side effects of HP including ischemic heart disease [1], sideropenic anemia [5], idiopathic thrombocytopenic purpura [6], neurologic diseases [7], and hepatobiliary diseases [8]. …”

Association between Acute Coronary Syndrome and Helicobacter Pylori Chronic Infection? What data mining tells us?

“…Currently extra-gastric H.Pylori manifestations are well known such as sideroplastic anemia and vitamin B12 deficiency. Nevertheless cardiac diseases and atherosclerosis have been also reported [3,4]. Data mining programs being a break through resolution of bioinformatics related-big data analyses or even for prediction future medicine, may discover such dilemma of association, dissociation or partially associated organ-microorganism conditional disorders.…”