The association between bacterial colonization and inflammatory pattern in Chinese chronic rhinosinusitis patients with nasal polyps

Ba, Luo; Zhang, Nan; Meng, Juan; Zhang, J; Lin, Ping; Zhou, Ping; Liu, S; Bachert, Claus

doi:10.1111/j.1398-9995.2011.02637.x

Cited by 80 publications

(72 citation statements)

References 22 publications

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“…The association of albumin with eosinophil products can be related to observations in nasal polyps where increased albumin deposition has been thought to be caused by eosinophil-driven inflammation 15 . The expression of neutrophilic and proinflammatory cytokines has been observed previously in Chinese nasal polyp patients 9 and more specifically in Chinese nasal polyp patients that were IL-5/IL-17/IFN-γ negative 22 .…”

Section: Discussionmentioning

confidence: 81%

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Tomassen

Vandeplas

Zele

et al. 2016

Journal of Allergy and Clinical Immunology

900

934

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Section: Discussionmentioning

confidence: 81%

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Tomassen

Vandeplas

Zele

et al. 2016

Journal of Allergy and Clinical Immunology

900

934

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“…The pathogenesis of CRSwNP involves complex inflammation regulated by various chemical mediators and (Jareoncharsri et al 2002) showed that 81.9% of NP was neutrophilpredominant, supported by study done in China (Ba et al 2011). This suggested that Asian population might have different pathological mechanism from Caucasian population.…”

Section: Discussionmentioning

confidence: 99%

“…However, research studies conducted in India and Asian countries showed that about 48-69% of NP was neutrophil predominant and had lower cases of eosinophil-predominant NP compared to the Caucasian studies (Dafale et al 2012;Hao et al 2006;Ba et al 2011). A study showed 17% of the sample were in combination of eosinophil and neutrophil, and 27% of NP had high level of mast cell, suggesting that the pathogenic mechanism of NP involved a complex inflammation included other inflammatory cells (Hao et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Malaysian Nasal Polyps: Eosinophil or Neutrophil-Predominant

Husain¹

2016

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ABSTRAK Polip hidung jenis eosinofil biasa terjadi dalam populasi ABSTRACTEosinophil-type nasal polyp (NP) is common in Western population. This aim of this study was to determine the histology type of NP among different Malaysian ethnic groups. A total of 122 chronic rhinosinusitis with nasal polyposis (CRSwNP) patients were retrospectively enrolled and demographic data was recorded. The histological slides were retrieved. The number of eosinophils and non-eosinophils were counted and average number of inflammatory cells for each high power field was calculated. Eosinophil-predominant was seen in 32.8% of patients and 67.2% was non-eosinophil-predominant. Phenotypes of NP significantly showed 57

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“…Non-eosinophilic CRSwNP always presents with neutrophil-predominant inflammation (6). The subgroups have a variety of pathogeneses and may require different therapeutic options.…”

Section: Introductionmentioning

confidence: 99%

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Cheng

Wang

2016

Experimental and Therapeutic Medicine

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Abstract. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of inflammation and Staphylococcus aureus enterotoxin (SE) in this disease. The study included a total of 74 patients with CRSwNP and 6 controls. A serum Phadiatop assay was conducted to detect atopy status, and serum eosinophil cationic protein (ECP) and total immunoglobulin (Ig)E levels were determined using ELISA. SEA, SEB, total IgE, ECP and myeloperoxidase (MPO) levels in nasal tissue supernatant were measured using ELISA. The results indicated that 15 (22.1%) patients had systemic allergies. On the basis of the ECP/MPO ratio, the patients were divided into an eosinophilic CRSwNP group (n=18) and a non-eosinophilic CRSwNP group (n=56). The total ECP/MPO ratio was 0.572, with a notable bias toward neutrophilic inflammation. The supernatant ECP and MPO levels were elevated in the CRSwNP group compared with the control group, but no significant difference in the serum total IgE and ECP levels were observed between the CRSwNP and control groups. In addition, the non-eosinophilic and eosinophilic CRSwNP groups showed significant elevations in supernatant total IgE, SEA and SEB levels compared with the control group. Thus, it may be concluded that allergy is a common pathogenesis of CRSwNP, and neutrophilic inflammation is present in most Chinese CRSwNP patients. Additionally, local indicators reflect the inflammatory status more accurately than do serum indicators. SEs may act as an infection factor rather than as a superantigen in Chinese non-eosinophilic CRSwNP patients. Thus, long-term antibiotic therapy may be an option for Chinese non-eosinophilic CRSwNP patients.

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The association between bacterial colonization and inflammatory pattern in Chinese chronic rhinosinusitis patients with nasal polyps

Abstract: Our findings suggest that the bacteria colonizing nasal polyps of CRSwNP patients may impact on or be determined by the presence/absence of IL-5.

Cited by 80 publications

References 22 publications

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Malaysian Nasal Polyps: Eosinophil or Neutrophil-Predominant

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

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