The association analysis of lncRNA<i>HOTAIR</i>genetic variants and gastric cancer risk in a Chinese population

Du, Mulong; Wang, Weizhi; Jin, Hua; Wang, Qiaoyan; Ge, Yuqiu; Lü, Jiafeng; Ma, Gaoxiang; Chu, Haiyan; Tong, Na; Zhu, Hao; Wang, Meilin; Fu, Qiang

doi:10.18632/oncotarget.5158

Cited by 99 publications

(96 citation statements)

References 27 publications

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“…In current study, we detected significant associations between the rs4759314 and rs7958904 and EOC susceptibility among Chinese population, some studies have also demonstrated significant associations between rs7958904 and decreased risk of colorectal cancer [7], rs4759314 with the increased gastric cancer risk [20]. The major strength of this study is the use of a large sample size to study genetic predispositions, which are less likely to be affected by confounding factors.…”

Section: Discussionmentioning

confidence: 56%

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Genetic variants of lncRNA HOTAIR and risk of epithelial ovarian cancer among Chinese women

Shang

Shi

et al. 2016

Oncotarget

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Ovarian cancer is one of the common female malignant tumors globally. However, exactly mechanism of ovarian cancer remained unknown. HOTAIR, a lncRNA in the mammalian HOXC locus, has been fully explored for its genetic variants, expression level and carcinogenesis, development and progression of multiple cancers, except for ovarian cancer. In this study, we hypothesized that abnormal expression of HOTAIR and common variants of HOTAIR are associated with risk of Epithelial ovarian cancer (EOC). We first evaluated the HOTAIR levels in 100 paired tissues of EOC patients and corresponding normal tissues. Results showed that the expression level of HOTAIR in EOC tissues was significantly higher than that in corresponding normal tissues. Then the genotyping analyses of HOTAIR gene was conducted in a Chinese population. The results indicated that rs4759314 and rs7958904 were significantly associated with EOC susceptibility. For rs4759314, the difference between the G allele (as the reference) and the A allele was statistically significant (adjusted OR, 1.34; 95% CI: 1.08–1.65; P = 6.8 × 10−3). For rs7958904, C allele was associated a significantly decreased EOC risk when compared with G allele (OR: 0.77; 95% CI: 0.67–0.89; P = 4.2 × 10−4). The study identified that HOTAIR variants could be a useful biomarker for the predisposition to EOC and for the early diagnosis of the disease.

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Section: Discussionmentioning

confidence: 56%

“…The lncRNA HOTAIR could modify the progress of carcinogenesis [7, 12, 20]. HOTAIR (for HOX transcript antisense RNA), was located on chromosome 12: 53.96–53.97 Mb [15].…”

Section: Discussionmentioning

confidence: 99%

Genetic variants of lncRNA HOTAIR and risk of epithelial ovarian cancer among Chinese women

Shang

Shi

et al. 2016

Oncotarget

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“…A possible mechanism underlying the association of these alleles to increased susceptibility is through the regulation of the expression of HOTAIR itself. Polymorphism rs4759314 resides in an intronic promoter region, which was found to influence the activity of this promoter and expression of HOXC11 gene [23]. For polymorphism rs4759314 , increased HOTAIR expression originated from the G (relative to the A) allele in luciferase reporter assays.…”

Section: Discussionmentioning

confidence: 99%

Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type

Wang

Huang

et al. 2016

Oncotarget

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Polymorphisms in the HOX transcript antisense intergenic RNA (HOTAIR) have been recently associated with susceptibility to different cancers. Here, a meta-analysis was performed to derive a more precise estimation of the involvement of HOTAIR polymorphisms in cancer development. Data from cases (n = 7,772) and controls (n = 9,075) were extracted from eligible studies (n = 10) identified in a comprehensive literature search conducted in PubMed, Embase, and the Web of Science databases through January 20, 2016. Overall, association between polymorphism rs920778 and increased cancer risk was significant in allele contrast (odds ratio (OR) = 1.239, 95% confidence interval (CI) = 1.032 - 1.487) and recessive models (OR = 1.614, 95% CI = 1.082 - 2.406). In subgroup analysis based on ethnicity, a significant association between polymorphism rs920778 and cancer susceptibility was observed in Asians under all models, but was most compelling under recessive (OR = 2.128, 95% CI = 1.417 - 3.197) and homozygous models (OR = 2.764, 95% CI = 2.221 - 3.440). Subgroup analysis by cancer type revealed a significant association between polymorphism rs4759314 and susceptibility to gastric cancer in allele contrast (OR = 1.262, 95% CI = 1.073 - 1.486), dominant (OR = 1.280, 95% CI = 1.060 - 1.547), and heterozygous models (OR = 1.288, 95% CI = 1.057 - 1.570). In conclusion, the results indicated that HOTAIR polymorphism rs920778 was more generally associated with cancer risk, particularly in Asians, while rs4759314 was a risk factor for gastric cancer.

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“…SNP rs4759314 was also significantly associated with increased risk of GC. Further functional experiments revealed allele-specific effects on HOTAIR expression in GC tissues; individuals with the AG genotype showed higher HOTAIR expression compared with those carrying the AA genotype, Nevertheless, whether HOTAIR SNP rs4759314 could act as a biomarker for predicting GC occurrence has yet to be determined [83]. Overall, accumulating evidence indicated that HOTAIR, which is present in tissues, blood, and gastric juice, was dysregulated in GC and related to tumorigenesis, metastasis, and progression, exhibiting potential as a biomarker for the diagnosis and prognosis of GC.…”

Section: Hotair In Gastric Cancermentioning

confidence: 99%

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

Tang

Hann

2018

Cell Physiol Biochem

208

135

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Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined. HOX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability. In this review, we briefly introduce the concept, identification, and biological functions of HOTAIR. We then describe the involvement of HOTAIR that has been associated with tumorigenesis, growth, invasion, cancer stem cell differentiation, metastasis, and drug resistance in cancer. We also discuss emerging insights into the role of HOTAIR as potential biomarkers and therapeutic targets for novel treatment paradigms in cancer.

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The association analysis of lncRNAHOTAIRgenetic variants and gastric cancer risk in a Chinese population

Cited by 99 publications

References 27 publications

Genetic variants of lncRNA HOTAIR and risk of epithelial ovarian cancer among Chinese women

Genetic variants of lncRNA HOTAIR and risk of epithelial ovarian cancer among Chinese women

Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

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