The application of selenium nanoparticles for enhancing the efficacy of photodynamic inactivation of planktonic communities and the biofilm of Streptococcus mutans

Shahmoradi, Samane; Shariati, Aref; Amini, Seyed Mohammad; Zargar, Nazanin; Yadegari, Zahra; Darban-Sarokhalil, Davood

doi:10.1186/s13104-022-05973-w

Cited by 14 publications

(18 citation statements)

References 34 publications

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“…Selenium nanoparticles can inhibit growth of S. mutans, E. faecalis, L. casei, C. albicans and Staphylococcus aureus ( S. aureus ) and their biofilms. 98 , 99 However, these studies were not performed on tooth tissue. Further studies are needed to explore the application of selenium nanomaterials for management of dental caries.…”

Section: Discussionmentioning

confidence: 99%

Caries Management with Non-Metallic Nanomaterials: A Systematic Review

Xu¹,

Nizami²,

Yin³

et al. 2022

IJN

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Background Non-metallic nanomaterials do not stain enamel or dentin. Most have better biocompatibility than metallic nanomaterials do for management of dental caries. Objective The objective of this study is to review the types, properties and potential uses of non-metallic nanomaterials systematically for managing dental caries. Methods Two researchers independently performed a literature search of publications in English using PubMed, Scopus and Web of Science. The keywords used were (nanoparticles OR nanocomposites OR nanomaterials) AND (caries OR tooth decay). They screened the titles and abstracts to identify potentially eligible publications of original research reporting non-metallic nanomaterials for caries management. Then, they retrieved and studied the full text of the identified publications for inclusion in this study. Results Out of 2497 resulting publications, this study included 75 of those. The non-metallic nanomaterials used in these publications were categorized as biological organic nanomaterials (n=45), synthetic organic nanomaterials (n=15), carbon-based nanomaterials (n=13) and selenium nanomaterials (n=2). They inhibited bacteria growth and/or promoted remineralization. They could be incorporated in topical agents (29/75, 39%), dental adhesives (11/75, 15%), restorative fillers (4/75, 5%), dental sealant (3/75, 4%), oral drugs (3/75, 4%), toothpastes (2/75, 3%) and functional candies (1/75, 1%). Other publications (22/75, 29%) do not mention specific applications. However, most publications (67/75, 89%) were in vitro studies. Six publications (6/75, 8%) were animal studies, and only two publications (2/75, 3%) were clinical studies. Conclusion The literature showed non-metallic nanomaterials have antibacterial and/or remineralising properties. The most common type of non-metallic nanomaterials for caries management is organic nanomaterials. Non-metallic nanomaterials can be incorporated into dental sealants, toothpaste, dental adhesives, topical agents and even candies and drugs. However, the majority of the publications are in vitro studies, and only two publications are clinical studies.

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Section: Discussionmentioning

confidence: 99%

Caries Management with Non-Metallic Nanomaterials: A Systematic Review

Xu¹,

Nizami²,

Yin³

et al. 2022

IJN

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“…34 These theoretical calculations were performed in the presence of ethanol solvent [keyword scrf = (default, solvent = ethanol)] by the DFT/ B3LYP method with the LANL2DZ basis set. 35 The HOMO and LUMO energy levels can serve as useful tools to provide a deep insight into the electronic and structural properties of chromone-porphyrins [ZnCP (7), DMCP (8), and PdCP (9)]. The HOMO energy level refers to the amount of energy needed to remove an electron from a molecule which corresponds to an oxidation process.…”

Section: Synthesis and Structuralmentioning

confidence: 99%

“…Conversely, the LUMO energy level indicates the energy required to add an electron to a molecule, signifying a reduction process. 36−38 The metal complex chromone-porphyrins [ZnCP (7) and PdCP (9)] have a larger HOMO−LUMO energy gap due to the presence of heavy atom ions, and it causes a redistribution of electron density within the porphyrin ring, which increases the energy required to excite an electron from the HOMO to the LUMO. 36,37 Both ZnCP and PdCP have less negative HOMO and LUMO values than DMCP.…”

Section: Synthesis and Structuralmentioning

confidence: 99%

“…9 Recently, one such approach involves the use of selenium nanoparticles (SeNPs), which have been employed as antibacterial and anti-biofilm agents for the photodynamic eradication of dental pathogens. 9 The potential of porphyrin-based photosensitizers is extensive, attributable to their exceptional photophysical properties. 10,11 Specifically, the coordination of metals (e.g., Zn and Pd) with porphyrin enhances the chemical stability and microbial interaction.…”

Section: ■ Introductionmentioning

confidence: 99%

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Synthesis of Metallo-Chromone Porphyrin Nano-Starch Sensitizers as Photodynamic Therapeutics for the Eradication of Enterococci Dental Pathogens

Gogde,

Paul,

Pujari

et al. 2023

J. Med. Chem.

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Photodynamic therapy (PDT), as an advanced, alternative, and promising treatment, can inhibit dental pathogens. PDT employs the activation of photosensitizers via the light of a particular wavelength and molecular oxygen to inhibit dental pathogens. Herein, we present a comprehensive study on the synthesis and characterization of three chromone-porphyrins [Zn(II)-5-[4-chromone]-15-(4-phenyl)porphyrin (ZnCP), 5-[4-chromone]-15-(4-12 phenyl)porphyrin (DMCP), and Pd(II)-5-[4-chromone]-15-(4-phenyl)porphyrin (PdCP)].Next, the computational study was also performed to establish the correlation between photophysical properties and theoretical calculations for those chromone-porphyrins using density functional theory and time-dependent density functional theory. Furthermore, chromone-porphyrins were encapsulated in starch nanoparticles to develop soluble nano-starch sensitizers (ZnCP-SNPs, DMCP-SNPs, and PdCP-SNPs) via the nanoprecipitation technique. Upon green light exposure, these nano-starch sensitizers exhibited excellent singlet oxygen generation ability. Moreover, final nanoformulations have been explored for pH responsiveness. Based on our intriguing findings, the chromone-porphyrin-loaded nano-starch sensitizers displayed great potential as prospective PDT to treat enterococci dental pathogens.

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“…Other PSs that have been considered safe and used to eradicate microorganisms involved in oral and dental diseases are synthetic fluorescent dyes such as the Indocyanine green (Nikinmaa et al, 2021;Wadhwa et al, 2021), 10.3389/fmicb.2022.1020995 Frontiers in Microbiology 03 frontiersin.org natural compounds such as Curcumin (Mendez et al, 2021;Moradi et al, 2021), nanosized natural zeolite (Ghazi et al, 2021), Riboflavin (Moradi et al, 2021), and Rose Bengal (Li et al, 2021). Various nanoparticle-integrated PSs have also been developed and investigated for their safety and efficacy in clinical applications (Hendi et al, 2021;Shahmoradi et al, 2022). There is a potential for side effects such as teeth staining, local damage to tissues and cells, possibility of overheating of the oral tissues and also risk of damage to eye and skin with overexposure to high intensity irradiations that should be considered when conducting clinical studies (Nielsen et al, 2015;Costa et al, 2016;Afrasiabi et al, 2022;Solarte et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of antimicrobial photodynamic therapy in dentistry

et al. 2023

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Given the emergence of resistant bacterial strains and novel microorganisms that globally threaten human life, moving toward new treatment modalities for microbial infections has become a priority more than ever. Antimicrobial photodynamic therapy (aPDT) has been introduced as a promising and non-invasive local and adjuvant treatment in several oral infectious diseases. Its efficacy for elimination of bacterial, fungal, and viral infections and key pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Candida albicans, and Enterococcus faecalis have been investigated by many invitro and clinical studies. Researchers have also investigated methods of increasing the efficacy of such treatment modalities by amazing developments in the production of natural, nano based, and targeted photosensitizers. As clinical studies have an important role in paving the way towards evidence-based applications in oral infection treatment by this method, the current review aimed to provide an overall view of potential clinical applications in this field and summarize the data of available randomized controlled clinical studies conducted on the applications of aPDT in dentistry and investigate its future horizons in the dental practice. Four databases including PubMed (Medline), Web of Science, Scopus and Embase were searched up to September 2022 to retrieve related clinical studies. There are several clinical studies reporting aPDT as an effective adjunctive treatment modality capable of reducing pathogenic bacterial loads in periodontal and peri-implant, and persistent endodontic infections. Clinical evidence also reveals a therapeutic potential for aPDT in prevention and reduction of cariogenic organisms and treatment of infections with fungal or viral origins, however, the number of randomized clinical studies in these groups are much less. Altogether, various photosensitizers have been used and it is still not possible to recommend specific irradiation parameters due to heterogenicity among studies. Reaching effective clinical protocols and parameters of this treatment is difficult and requires further high quality randomized controlled trials focusing on specific PS and irradiation parameters that have shown to have clinical efficacy and are able to reduce pathogenic bacterial loads with sufficient follow-up periods.

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The application of selenium nanoparticles for enhancing the efficacy of photodynamic inactivation of planktonic communities and the biofilm of Streptococcus mutans

Cited by 14 publications

References 34 publications

Caries Management with Non-Metallic Nanomaterials: A Systematic Review

Caries Management with Non-Metallic Nanomaterials: A Systematic Review

Synthesis of Metallo-Chromone Porphyrin Nano-Starch Sensitizers as Photodynamic Therapeutics for the Eradication of Enterococci Dental Pathogens

Clinical applications of antimicrobial photodynamic therapy in dentistry

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