Caries Management with Non-Metallic Nanomaterials: A Systematic Review

Xu, Veena Wenqing; Nizami, Mohammed Zahedul Islam; Yin, Iris Xiaoxue; Lung, Christie Ying Kei; Yu, Ollie Yiru; Chu, Chun Hung

doi:10.2147/ijn.s389038

Cited by 10 publications

(8 citation statements)

References 98 publications

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“…There is no consensus among researchers on how to effectively assess the quality of in vitro studies [ 107 ]. The methods used in our review to assess the risk of bias were adapted from a systematic review of in vitro studies [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Peptide Designs for Use in Caries Management: A Systematic Review

Zhang

Niu

et al. 2023

IJMS

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The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in the included studies. This review identified 3592 publications, of which 62 were selected. Forty-seven studies reported 57 antimicrobial peptides. Among them, 31 studies (66%, 31/47) used the template-based design method; 9 studies (19%, 9/47) used the conjugation method; and 7 studies (15%, 7/47) used other methods, such as the synthetic combinatorial technology method, the de novo design method and cyclisation. Ten studies reported mineralising peptides. Seven of these (70%, 7/10) used the template-based design method, two (20%, 2/10) used the de novo design method, and one study (10%, 1/10) used the conjugation method. In addition, five studies developed their own peptides with antimicrobial and mineralising properties. These studies used the conjugation method. Our assessment for the risk of bias in the 62 reviewed studies showed that 44 publications (71%, 44/62) had a medium risk and that 3 publications had a low risk (5%, 3/62). The two most common methods for developing peptides for use in caries management that were used in these studies were the template-based design method and the conjugation method.

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Section: Discussionmentioning

confidence: 99%

Peptide Designs for Use in Caries Management: A Systematic Review

Zhang

Niu

et al. 2023

IJMS

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“…Articles categorize and classify nanomaterials used in different disciplines of dentistry, mainly based on their shape, composition, and function [5][6][7][8][9][10].…”

Section: Classifications Of Nanomaterials In Restorative Dentistrymentioning

confidence: 99%

“…Another classification and definition system for nanomaterials is provided, principally by their structures into metallic and nonmetallic categories [9].…”

Section: Nanomaterials Based On Carbon Nanotubes (Cnts)mentioning

confidence: 99%

A Comprehensive Narrative Review of Nanomaterial Applications in Restorative Dentistry: Demineralization Inhibition and Remineralization Applications (Part I)

Elmarsafy

2024

Cureus

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Nanotechnology is extensively employed in various aspects of dentistry, including restorative dentistry, because of its substantial improvement and promising potential in the clinical efficacy of restorative materials and procedures. The main purpose of this review is to explore the different uses of nanomaterials in restorative dentistry. The review is divided into two parts: the current review (Part 1) focuses on the prevention of demineralization and promotion of remineralization, while the upcoming review (Part 2) will discuss the reinforcement of restorative materials and their therapeutic applications. Nanofillers are added to dental materials to boost their antibacterial, anticaries, and demineralization inhibitory capabilities. Additionally, they improve remineralization and enhance both mechanical properties and therapeutic features. The nanoparticles (NPs) used to increase antibacterial and remineralization inhibitions can be classified into two main groups: inorganic and organic NPs. Examples of inorganic NPs include silver, zinc oxide, titanium oxide, and gold. Examples of organic NPs include silica, quaternary ammonium salt monomers, and chitosan NPs. Furthermore, the nanofillers utilized to enhance the process of remineralization include various types such as metals, nano-hydroxyapatite, nano-amorphous calcium phosphate (ACP), dicalcium phosphate NPs, casein phosphopeptide-ACP (CPP-ACP), and calcium fluoride NPs. These uses underscore the potential applications of NPs in restorative dentistry, although there are still some limitations to address.

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“…Two investigators independently assessed the risk of bias in individual studies. The evaluation was based on previous systematic reviews [4,14]. They assessed the quality of each study using seven parameters, which were: (1) presence of a control, (2) amount of material for assessment, (3) exposure time, (4) material characterization, (5) biocompatibility assessment, (6) blinding of observers and ( 7) sample size justification.…”

Section: Assessment Of Risk Of Biasmentioning

confidence: 99%

Copper Materials for Caries Management: A Scoping Review

Xu,

Nizami,

Yin

et al. 2023

JFB

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This study comprehensively reviewed the types, properties and potential applications of copper materials for caries management. Two researchers independently searched English publications using PubMed, Scopus and Web of Science. They screened the titles and abstracts of publications presenting original studies for review. They included 34 publications on copper materials, which were categorized as copper and copper alloy materials (13/34, 38%), copper salt materials (13/34, 38%) and copper oxide materials (8/34, 24%). All reported copper materials inhibited the growth of cariogenic bacteria such as Streptococcus mutans and Candida albicans. The materials could be doped into topical agents, restorative fillers, dental adhesives, drinking water, dental implants, orthodontic appliances, mouthwash and sugar. Most publications (29/34, 83%) were laboratory studies, five (5/34, 14%) were animal studies and only one paper (1/34, 3%) was clinical research. In conclusion, copper and copper alloy materials, copper salt materials and copper oxide materials have an antimicrobial property that inhibits cariogenic bacteria and Candida albicans. These copper materials may be incorporated into dental materials and even drinking water and sugar for caries prevention. Most publications are laboratory studies. Further clinical studies are essential to validate the effectiveness of copper materials in caries prevention.

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Caries Management with Non-Metallic Nanomaterials: A Systematic Review

Cited by 10 publications

References 98 publications

Peptide Designs for Use in Caries Management: A Systematic Review

Peptide Designs for Use in Caries Management: A Systematic Review

A Comprehensive Narrative Review of Nanomaterial Applications in Restorative Dentistry: Demineralization Inhibition and Remineralization Applications (Part I)

Copper Materials for Caries Management: A Scoping Review

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