The application of povidone in the preparation of modified release tablets

Abstract

The aim of the study was to investigate the modified release of a model substance, of tablets containing different types of Kollidon and particular additives. Additionally, the release kinetics and mechanism of prolonged release of certain tablet preparations were investigated. In this work, tablets containing different types of povidone (Kollidon CL, Kollidon 30, Kollidon SR and other excipients) were prepared by the direct compression technique. The results showed that tablets with fast disintegration and release should contain in their composition, Kollidon CL, lactose and Avicel, however, the use of β-CD instead of lactose or Avicel brings about a slight prolongation in the disintegration time of tablets and the release of an active substance. Furthermore, while other tablet compositions generated within this study must be considered as being prolonged release types, only two of these showed the best fitted mathematical models. The in vitro dissolution data reveal that the dissolution profiles of the two formulations, one containing Kollidon SR with the addition of Kollidon 30, and the second with HPMC K15M, Kollidon 30, Kollidon CL and lactose, best fitted the Higuchi model. Moreover, the release mechanism of these two formulations plotted well into Korsmeyer-Peppas, indicating a coupling of drug diffusion in the hydrated matrix, as well as polymer relaxation – the so-called anomalous transport (non-Fickian).

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

“…Examples of formulations include rifampicin, pyrazinamide, ranitidine effervescent, ascorbic acid effervescent tablets, etc. PVP polymers also gained a place in dry granulation [ 70 ] and direct compression [ 71 ] techniques. Direct compression is the simplest tableting process among all available methods.…”

Applications of synthetic and semisynthetic polymers (Kollidon K25, Kollidon K90 and Hydroksyethylocellulose) as carriers of ketoprofen in solid oral prolonged release dosage forms. The impact of selected non-ionic surfactants (Tween 80 and Rofam 70) on the release kinetic

“…Specyfika uwalniania API zależy od wzajemnych relacji ilościowo-lepkościowych składowych matrycy oraz od rodzaju i składu płynu akceptorowego (medium). 7 Ze względu na przynależność ketoprofenu do II grupy systemu klasyfikacji biofarmaceutycznej (ang. biopharmaceutics classification system -BCS) zaproponowane zostały modyfikacje do testu uwalniania przez wprowadzenie niejonowych surfaktantów (innowacyjnego Rofamu 70 oraz referencyjnego Tweenu 80) do płynu akceptorowego.…”

Modification of Nanocrystalline Silicon by Polymers for Biomedical Applications

“…The typical HRTEM images (JEM 2100 F/Cs instrument, JEOL) of the synthesized npSi/SiOx (Fig.1) clearly demonstrate a crystalline Si core with a diameter of ~2 nm for a "small" nanoparticle (a) and ~6 nm for "large" nanoparticle (b). The thickness of the amorphous SiOx shell in both cases is 1-1.5 nm В качестве модификаторов гидрофобной поверхности наночастиц кремния использовали биосовместимые поверхностно-активные полимеры: кремофор (Cremofor), поливинилпирролидон (PVP), сополимер малеинового ангидрида и 1октадецена (PMAO) [13][14][15]. Кремофор является распространенным коллоидным стабилизатором, используемым в рецептуре многих медицинских препаратов [16].…”