The application of personal glucose meters as universal point-of-care diagnostic tools

Lisi, Fabio; Peterson, James L.; Gooding, J. Justin

doi:10.1016/j.bios.2019.111835

Cited by 73 publications

(43 citation statements)

References 110 publications

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“…The corresponding glucose signal varies between 24 and 350 mg/dL. The latter is far from the upper limit of the glucometer, where some PGM models lose their linear behavior [ 11 ]. Wider dynamic ranges have been described for nucleic acid quantification employing the PGM readout [ 27 , 28 ] but, considering the restricted detection range of the PGM (about one order of magnitude), the sensitivity of these genoassays tends to be lower, so a very small relative standard deviation is required for reliable quantification.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, endogenous glucose present in human bodily fluids such as blood and, to a lesser extent, urine and tears could lead to non-negligible background signals. To circumvent this issue, different strategies have been proposed (performing two measurements, sample dilution, enzymatic removal) [ 11 ]. The use of magnetic beads as a solid support of the hybridization event can also help in this sense.…”

Section: Discussionmentioning

confidence: 99%

“…This user-friendly device employed by millions of people with diabetes around the world is the result of many years of work in which the blood glucose meter evolved from photometric detection used in the 1960s until the current electrochemical detection using reactions based on oxidoreductase enzymes [ 7 ]. Considering its commercial availability at low cost as well as its portability and accuracy [ 8 ], the PGM has become a particularly promising portable meter for targets beyond glucose [ 9 , 10 , 11 ]. With this aim, different methods to correlate the concentration of the biomarker to the glucose signal recorded with the PGM have been reported, and they can be clustered into two main groups.…”

Section: Introductionmentioning

confidence: 99%

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New Uses for the Personal Glucose Meter: Detection of Nucleic Acid Biomarkers for Prostate Cancer Screening

Abardía-Serrano

Miranda‐Castro

de‐los‐Santos‐Álvarez

et al. 2020

Sensors

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A personal glucose meter (PGM)-based method for quantitative detection of a urinary nucleic acid biomarker in prostate cancer screening, the so-called PCA3, is reported herein. A sandwich-type genoassay is conducted on magnetic beads to collect the target from the sample by specific hybridization, making the assay appropriate for PCA3 detection in biological fluids. The success of the method hinges on the use of alkaline phosphatase (ALP) to link the amount of nucleic acid biomarker to the generation of glucose. In particular, specifically attached ALP molecules hydrolyze D-glucose-1-phosphate into D-glucose, thus enabling the amplification of the recorded signal on the personal glucose meter. The developed genoassay exhibits good sensitivity (3.3 ± 0.2 mg glucose dL−1 pM−1) for PCA3, with a dynamic range of 5 to 100 pM and a quantification limit of 5 pM. Likewise, it facilitates point-of-care testing of nucleic acid biomarkers by using off-the-shelf PGM instead of complex instrumentation involved in traditional laboratory-based tests.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New Uses for the Personal Glucose Meter: Detection of Nucleic Acid Biomarkers for Prostate Cancer Screening

Abardía-Serrano

Miranda‐Castro

de‐los‐Santos‐Álvarez

et al. 2020

Sensors

View full text Add to dashboard Cite

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“…At the beginning of the twenty-first century, the use of sensors and mobile internet begins to provide a platform to continuously monitor all vital signs [12][13][14][15][16][17][18][19][20], including blood pressure. Not only does this help reduce the risk of cardiovascular complications, but also it supports making accurate and real-time healthcare data available for healthcare professionals at the office to assist select the best treatment strategies and consider the impact on patient outcomes [21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Blood Pressure Sensors: Materials, Fabrication Methods, Performance Evaluations and Future Perspectives

Al-Qatatsheh

Morsi

Zavabeti

et al. 2020

Sensors

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Advancements in materials science and fabrication techniques have contributed to the significant growing attention to a wide variety of sensors for digital healthcare. While the progress in this area is tremendously impressive, few wearable sensors with the capability of real-time blood pressure monitoring are approved for clinical use. One of the key obstacles in the further development of wearable sensors for medical applications is the lack of comprehensive technical evaluation of sensor materials against the expected clinical performance. Here, we present an extensive review and critical analysis of various materials applied in the design and fabrication of wearable sensors. In our unique transdisciplinary approach, we studied the fundamentals of blood pressure and examined its measuring modalities while focusing on their clinical use and sensing principles to identify material functionalities. Then, we carefully reviewed various categories of functional materials utilized in sensor building blocks allowing for comparative analysis of the performance of a wide range of materials throughout the sensor operational-life cycle. Not only this provides essential data to enhance the materials’ properties and optimize their performance, but also, it highlights new perspectives and provides suggestions to develop the next generation pressure sensors for clinical use.

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“…Also, inexpensive, disposable SPE arrays designed to be read by portable meters similar to glucose meters EI could be mass-produced. The resulting EI platform would enable an extremely wide range of molecular and cellular analytes to be accurately measured with high sensitivity and selectivity, ease of use, low cost, and portability [ 11 , 12 , 13 , 14 , 15 ]. Prototype EI systems have been developed for healthcare applications.…”

Section: Introductionmentioning

confidence: 99%

Integrated Experimental and Theoretical Studies on an Electrochemical Immunosensor

et al. 2020

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Electrochemical immunosensors (EIs) integrate biorecognition molecules (e.g., antibodies) with redox enzymes (e.g., horseradish peroxidase) to combine the advantages of immunoassays (high sensitivity and selectivity) with those of electrochemical biosensors (quantitative electrical signal). However, the complex network of mass-transfer, catalysis, and electrochemical reaction steps that produce the electrical signal makes the design and optimization of EI systems challenging. This paper presents an integrated experimental and modeling framework to address this challenge. The framework includes (1) a mechanistic mathematical model that describes the rate of key mass-transfer and reaction steps; (2) a statistical-design-of-experiments study to optimize operating conditions and validate the mechanistic model; and (3) a novel dimensional analysis to assess the degree to which individual mass-transfer and reaction steps limit the EI’s signal amplitude and sensitivity. The validated mechanistic model was able to predict the effect of four independent variables (working electrode overpotential, pH, and concentrations of catechol and hydrogen peroxide) on the EI’s signal magnitude. The model was then used to calculate dimensionless groups, including Damkohler numbers, novel current-control coefficients, and sensitivity-control coefficients that indicated the extent to which the individual mass-transfer or reaction steps limited the EI’s signal amplitude and sensitivity.

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The application of personal glucose meters as universal point-of-care diagnostic tools

Cited by 73 publications

References 110 publications

New Uses for the Personal Glucose Meter: Detection of Nucleic Acid Biomarkers for Prostate Cancer Screening

New Uses for the Personal Glucose Meter: Detection of Nucleic Acid Biomarkers for Prostate Cancer Screening

Blood Pressure Sensors: Materials, Fabrication Methods, Performance Evaluations and Future Perspectives

Integrated Experimental and Theoretical Studies on an Electrochemical Immunosensor

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