The application of mesenchymal stem cells to treat thermal and radiation burns

Rodgers, Kathy; Jadhav, Sachin Suresh

doi:10.1016/j.addr.2017.10.003

Cited by 49 publications

(32 citation statements)

References 84 publications

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“…Progress in using MSCs for the treatment of various disorders is continuously growing and the scope for their potential application is becoming wider. The broad spectrum of pathologies where MSCs can be applied, either as an injectable suspension or within a scaffold or hydrogels, has been reported elsewhere and includes wounds 1,2 , bone and cartilage defects 3 , graft-versus-host disease 4 , cardiovascular 5,6 or neural disorders (multiple sclerosis, stroke, spinal cord injury etc.) [7][8][9] .…”

mentioning

confidence: 99%

A Comparative Analysis of Multipotent Mesenchymal Stromal Cells derived from Different Sources, with a Focus on Neuroregenerative Potential

Petrenko

Vacková

Kekulová

et al. 2020

Sci Rep

134

109

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Multipotent mesenchymal stromal cells (MScs) can be considered an accessible therapeutic tool for regenerative medicine. Here, we compared the growth kinetics, immunophenotypic and immunomodulatory properties, gene expression and secretome profile of MSCs derived from human adult bone marrow (BM-MSCs), adipose tissue (AT-MSCs) and Wharton's jelly (WJ-MSCs) cultured in clinically-relevant conditions, with the focus on the neuroregenerative potential. All the cell types were positive for CD10/CD29/CD44/CD73/CD90/CD105/HLA-ABC and negative for CD14/CD45/CD235a/ CD271/HLA-DR/VEGFR2 markers, but they differed in the expression of CD34/CD133/CD146/SSEA-4/ MSCA-1/CD271/HLA-DR markers. BM-MSCs displayed the highest immunomodulatory activity compared to AT-and WJ-MSCs. On the other hand, BM-MSCs secreted the lower content and had the lower gene expression of neurotrophic growth factors compared to other cell lines, which may be caused by the higher sensitivity of BM-MSCs to nutrient limitations. Despite the differences in growth factor secretion, the MSC secretome derived from all cell sources had a pronounced neurotrophic potential to stimulate the neurite outgrowth of DRG-neurons and reduce the cell death of neural stem/progenitor cells after H 2 o 2 treatment. Overall, our study provides important information for the transfer of basic MSC research towards clinical-grade manufacturing and therapeutic applications.

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mentioning

confidence: 99%

A Comparative Analysis of Multipotent Mesenchymal Stromal Cells derived from Different Sources, with a Focus on Neuroregenerative Potential

Petrenko

Vacková

Kekulová

et al. 2020

Sci Rep

134

109

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“…According to published literature, chronic inflammation in radiation wounds often leads to subsequent waves of tissue injury leading to skin breakdown and necrosis. These waves can occur weeks, months, or years after the initial injury . Fluctuations in wound size were observed during the course of treatment prior to vLPM application.…”

Section: Discussionmentioning

confidence: 99%

“…These waves can occur weeks, months, or years after the initial injury. [25][26][27] Fluctuations in wound size were observed during the course of treatment prior to vLPM application. As such, it is unlikely that wound size fluctuations were a result of vLPM application.…”

Section: Discussionmentioning

confidence: 99%

Management of a chronic radiation necrosis wound with lyopreserved placental membrane containing viable cells

Regulski

Danilkovitch

Saunders

2019

Clinical Case Reports

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“…Therefore, one of the main aims of burn treatment is to keep tissue damage to a minimum (Singh, Devgan, Bhat, & Milner, 2007;Rodgers & Jadhay, 2018). They lead to infections and shock in the early period and delay healing.…”

Section: Introductionmentioning

confidence: 99%

“…Later, there may be hypertrophic scars, pigmentation disorders, and contracture. Therefore, one of the main aims of burn treatment is to keep tissue damage to a minimum (Singh, Devgan, Bhat, & Milner, 2007;Rodgers & Jadhay, 2018).…”

Section: Introductionmentioning

confidence: 99%

The effects of epidermal growth factor on early burn‐wound progression in rats

Kaya

Orhan

Sapmaz-Metin

et al. 2019

Dermatologic Therapy

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After burns, protecting tissues by medicines in the zone of stasis reduces the width and depth of injury. This study's goal was to reduce burned tissue damage in the zone of stasis using epidermal growth factor (EGF). Forty-eight Wistar rats were separated into three groups. In all groups, the burn procedure was applied following the comb burn model. In Group 1, no postburn treatment was administered. In Group 2, physiological saline solution (0.3 cc) was injected intradermally and in Group 3, EGF (0.3 cc) was injected intradermally into stasis zone tissues after the burn procedure. Surviving tissue rates were 24.0% in Group 1, 25.3% in Group 2, and 70.2% in Group 3. The average numbers of cells stained with Nrf2, HO-1, and the number of apoptotic cells were 230, 150, and 17.5 in Group 1, 230, 145, and 15.0 in Group 2, and 370, 230, and 0 in Group 3, respectively. Values in Group 3 were found to be statistically significantly different than those of Groups 1 and 2; there was no difference between Groups 1 and 2. This study shows that EGF protects zone of stasis tissue from burn damage. K E Y W O R D Sburn, epidermal growth factor, zone of stasis

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The application of mesenchymal stem cells to treat thermal and radiation burns

Cited by 49 publications

References 84 publications

A Comparative Analysis of Multipotent Mesenchymal Stromal Cells derived from Different Sources, with a Focus on Neuroregenerative Potential

A Comparative Analysis of Multipotent Mesenchymal Stromal Cells derived from Different Sources, with a Focus on Neuroregenerative Potential

Management of a chronic radiation necrosis wound with lyopreserved placental membrane containing viable cells

The effects of epidermal growth factor on early burn‐wound progression in rats

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