Management of a chronic radiation necrosis wound with lyopreserved placental membrane containing viable cells

Regulski, Matthew; Danilkovitch, Alla; Saunders, Molly

doi:10.1002/ccr3.2011

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Stem cells derived from placental membrane and lipoaspirates have shown effectiveness in treating chronic radiation-induced injuries, even in cases where other modalities have failed. 15,16 Additionally, a combination of stem cell-released molecules from various types of skin stem cells has demonstrated efficacy in acute radiation dermatitis, leading to significant symptom reduction and complete wound healing. 17 Very few studies have utilized platelet rich plasma, although it may provide accelerated wound healing.…”

Section: Discussionmentioning

confidence: 99%

A Case Series and Literature Review: Management Strategies for Radiation-Induced Ulcers of the Chest

Kristine,

Pribadi,

Syed Faqeer Hussain Bokhari

2024

JRE

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Highlights: Radiotherapy leads to a high occurrence of skin alterations and can advance to different levels of tissue damage, presenting challenges in treatment. Management can be effective employing diverse wound treatment methods, although severe cases may necessitate surgical intervention. Surgery takes into several key considerations to increase chances of success and tackle specific issues of chest wall instability and breast reconstruction. Abstract: Introduction: Radiotherapy as an adjunct to cancer treatment causes a high incidence of radiation-induced tissue injury, ranging from radiation dermatitis to severe osteoradionecrosis. Currently, no gold standard exists in the management of radiation injury. Various strategies ranging from modern wound treatment to surgical management have been studied. Case Illustration: Three women presented with varying degrees of ulceration in the chest during or shortly following radiotherapy. Each case followed different approaches to management. One case solely received wound treatment, another received wound treatment and a sequestrectomy, and the third required surgical reconstruction of the chest wall and defect. Discussion: Methods of wound treatment range from topical agents, barrier films and dressings, hydrogel and hydrocolloid dressings, miscellaneous treatments, and biodressings. Surgery is required in severe cases, particularly with osteoradionecrosis. This may include wound debridement, biopsy, chest wall stabilization, closure using various flaps, and potential breast reconstruction. Conclusion: Radiation-induced ulcers of the chest pose a complex issue. Understanding effective treatment methods and key surgical principles is important for ensuring better outcomes. Further studies are needed to provide a complete guide to treatment.

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Section: Discussionmentioning

confidence: 99%

A Case Series and Literature Review: Management Strategies for Radiation-Induced Ulcers of the Chest

Kristine,

Pribadi,

Syed Faqeer Hussain Bokhari

2024

JRE

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“…American researchers reported a case of a patient with chronic radiation necrosis treated with a lyopreserved placental membrane containing viable cells [57]. The 73-yearold woman received postoperative radiotherapy due to squamous cell carcinoma of the right medial ankle, and she developed a chronic necrotic wound refractory to conventional treatment (collagen dressings, honey-impregnated dressings, topical and oral antibiotics).…”

Section: Dressings In Crd Prevention and Treatmentmentioning

confidence: 99%

Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—A Literature Review

2022

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Radiotherapy is an integral part of modern oncology, applied to more than half of all patients diagnosed with cancer. It can be used alone or in combination with surgery or chemotherapy. However, despite the high precision of radiation delivery, irradiation may affect surrounding healthy tissues leading to the development of toxicity. The most common and clinically significant toxicity of radiotherapy is acute and chronic radiation dermatitis, which could result in desquamation, wounds, nonhealing ulcers, and radionecrosis. Moreover, preoperative radiotherapy impairs wound healing after surgery and may lead to severe wound complications. In this review, we comprehensively discuss available types of dressings used in the management of acute and chronic radiation dermatitis and address their efficacy. The most effective ways of preventing acute radiation dermatitis are film dressings, whereas foam dressings were found effective in its treatment. Data regarding dressings in chronic radiation dermatitis are scarce. This manuscript also contains authors’ consensus.

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“…More recently, use of PM in the field of dermatology has been explored, including applications of PM in Mohs surgery, in the management of chronic radiation necrosis, and in the treatment of pyoderma gangrenosum cases [ 92 – 94 ], A case series of the use of dehydrated PM Mohs micrographic surgery for large full-thickness (to the bone) scalp wounds found treatment was well tolerated and resulted in the development of granulation tissue [ 95 ]. A case of a 77-year old female with pyoderma gangrenosum treated with dehydrated PM as an adjunct to immunosuppressives reported pain reduction from 10/10 to 5/10 within hours of application that decreased to 0/10 after 1 week and a 56% reduction in wound size after 3 applications.…”

Section: Placental Membranementioning

confidence: 99%

Placental Tissues as Biomaterials in Regenerative Medicine

Roy

Mantay

Brannan

et al. 2022

BioMed Research International

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Placental tissues encompass all the tissues which support fetal development, including the placenta, placental membrane, umbilical cord, and amniotic fluid. Since the 1990s there has been renewed interest in the use of these tissues as a raw material for regenerative medicine applications. Placental tissues have been extensively studied for their potential contribution to tissue repair applications. Studies have attributed their efficacy in augmenting the healing process to the extracellular matrix scaffolds rich in collagens, glycosaminoglycans, and proteoglycans, as well as the presence of cytokines within the tissues that have been shown to stimulate re-epithelialization, promote angiogenesis, and aid in the reduction of inflammation and scarring. The compositions and properties of all birth tissues give them the potential to be valuable biomaterials for the development of new regenerative therapies. Herein, the development and compositions of each of these tissues are reviewed, with focus on the structural and signaling components that are relevant to medical applications. This review also explores current configurations and recent innovations in the use of placental tissues as biomaterials in regenerative medicine.

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Management of a chronic radiation necrosis wound with lyopreserved placental membrane containing viable cells

Cited by 5 publications

References 23 publications

A Case Series and Literature Review: Management Strategies for Radiation-Induced Ulcers of the Chest

A Case Series and Literature Review: Management Strategies for Radiation-Induced Ulcers of the Chest

Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—A Literature Review

Placental Tissues as Biomaterials in Regenerative Medicine

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