The effects of epidermal growth factor on early burn‐wound progression in rats

Abstract

After burns, protecting tissues by medicines in the zone of stasis reduces the width and depth of injury. This study's goal was to reduce burned tissue damage in the zone of stasis using epidermal growth factor (EGF). Forty-eight Wistar rats were separated into three groups. In all groups, the burn procedure was applied following the comb burn model. In Group 1, no postburn treatment was administered. In Group 2, physiological saline solution (0.3 cc) was injected intradermally and in Group 3, EGF (0.3 cc) was injected intradermally into stasis zone tissues after the burn procedure. Surviving tissue rates were 24.0% in Group 1, 25.3% in Group 2, and 70.2% in Group 3. The average numbers of cells stained with Nrf2, HO-1, and the number of apoptotic cells were 230, 150, and 17.5 in Group 1, 230, 145, and 15.0 in Group 2, and 370, 230, and 0 in Group 3, respectively. Values in Group 3 were found to be statistically significantly different than those of Groups 1 and 2; there was no difference between Groups 1 and 2. This study shows that EGF protects zone of stasis tissue from burn damage. K E Y W O R D Sburn, epidermal growth factor, zone of stasis

Clinical Study of Rh-bFGF Combined With Collagen Sponge in the Treatment of Maxillofacial Deep Ⅱ Degree Burn

“…11 EGF can accelerate the repair of wound skin and mucosa by promoting the proliferation and differentiation of skin epidermal cells. 12 VEGF can increase vascular permeability, promote endothelium proliferation and differentiation, form new blood vessels, improve local blood supply, and accelerate tissue repair. 13 The results showed that the levels of EGF and VEGF in the observation group were significantly higher than those in the control group (P < 0.05) after 14 days of treatment, indicating that rh-bFGF can significantly increase the levels of EGF and VEGF in patients with deep Ⅱ degree burn wound.…”

“…The production of EGF and VEGF is promoted following trauma or infection 11 . EGF can accelerate the repair of wound skin and mucosa by promoting the proliferation and differentiation of skin epidermal cells 12 . VEGF can increase vascular permeability, promote endothelium proliferation and differentiation, form new blood vessels, improve local blood supply, and accelerate tissue repair 13 .…”

Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

“…The highest surviving rate was observed in group 3 (70.2%) compared with the others two group. No difference was detected between groups 1 and 2 [79]. EGF protects the zone of stasis tissue from burn damage [79].…”

“…No difference was detected between groups 1 and 2 [79]. EGF protects the zone of stasis tissue from burn damage [79]. It can also correct the pseudo-healing of traumatic tympanic membrane perforations, after daily application over six months, to keep the membrane moist [80].…”

Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials

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