2020
DOI: 10.1371/journal.pone.0232117
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The application of BMRT-HPV viral load to secondary screening strategies for cervical cancer

Abstract: Objective Evaluate the significance of BMRT HPV assay viral load and its performance for secondary screening. Methods BMRT-HPV reports type-specific viral loads/10,000 cells. We tested 1,495 physician collected, stored specimens from Chinese Multiple-center Screening Trial (CHIMUST), that were positive by Cobas, SeqHPV, and/or Cytology (�LSIL); and 2,990 age matched, negatives in a nested case control study. We explored the relationship between BMRT HR-HPV viral load and cervical lesions, determined alternativ… Show more

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Cited by 19 publications
(21 citation statements)
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“…No similar undertaking could be done for the CmPV1 results as there are no comparable datasets in marine turtles. However, the results are consistent with human cervical intraepithelial neoplasia (CIN) I, II, III caused by human papillomavirus (HPV) 16, 18, 33 and 58 [ 48 , 49 , 50 ].…”
Section: Resultssupporting
confidence: 57%
See 1 more Smart Citation
“…No similar undertaking could be done for the CmPV1 results as there are no comparable datasets in marine turtles. However, the results are consistent with human cervical intraepithelial neoplasia (CIN) I, II, III caused by human papillomavirus (HPV) 16, 18, 33 and 58 [ 48 , 49 , 50 ].…”
Section: Resultssupporting
confidence: 57%
“…While the mean ChHV5 load results obtained in this study were consistent with other reports [ 23 , 25 , 45 , 46 ], such comparisons could not be made for CmPV1 as there are no other comparable datasets in marine turtles. However, the CmPV1 viral loads are in the same range reported for human cervical malignancies caused by HPV 16, 18, 33 and 58 where the mean HPV copies per 10,000 cells were reported to be ~log3–5 in CIN I, II and III [ 48 , 49 , 50 ].…”
Section: Discussionmentioning
confidence: 52%
“…Women testing HPV positive by either Cobas or SeqHPV (self or direct) were referred for colposcopy, using the quadrant-based POI (Preventive Oncology International Inc.) protocol of directed and random biopsies plus ECC [8]. The implementation and methods of the trial have been detailed in prior publications [9,10].…”
Section: Study Populationmentioning
confidence: 99%
“…While the mean ChHV5 load results obtained in this study were consistent with other reports [24,44,45], such comparisons could not be made for CmPV1 as there are no other comparable datasets in marine turtles. However, the CmPV1 viral loads are in the same range reported for human cervical malignancies caused by HPV 16, 18, 33 and 58 where the mean HPV copies per 10,000 cells were reported to be ~log3-5 in CIN I, II and III [47][48][49]. Additional molecular surveys targeting both ChHV5 and CmPV1 from other regions would be hugely beneficial to understanding the role of CmPV1 in FP, and in marine turtle health as a whole.…”
Section: Mean Viral Loadmentioning
confidence: 64%