The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women

Guo, Chunfang; Du, Hui; Belinson, Jerome L.; Wang, Chun; Huang, Xia; Qu, Xiaoyan; Wu, Ruifang

doi:10.1186/s13027-021-00360-9

Cited by 9 publications

(8 citation statements)

References 44 publications

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“…Among the sampled regions, Haikou (31.94%), Beijing (21.06%), and Guangdong (20.02%) have the highest HPV incidences. Our results are consistent with HPV distribution characteristics previously reported in China 25 – 27 . The overall HPV infection rate is high and single-type as well as high-risk infections are more common.…”

Section: Discussionsupporting

confidence: 93%

The prevalence of human papillomavirus among women in northern Guangdong Province of China

Huang

et al. 2022

Sci Rep

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Globally, cervical cancer, whose etiologic factor is Human papillomavirus (HPV), is the third most common cancer among women. In cervical cancer screening, HPV testing is important. However, the prevalence of HPV in northern Guangdong Province has not been conclusively determined. A total of 100,994 women attending Yuebei People's Hospital Affiliated to Shantou University Medical College between 2012 and 2020 were recruited. HPV was tested by a polymerase chain reaction (PCR)-based hybridization gene chip assay. The prevalence of HPV among these women was established to be19.04%. Peak prevalence was observed in women aged 40–49 (7.29%). Besides, the prevalence of single-type HPV infection (14.46%) was significantly high, compared to multiple-type infection (4.58%) (p < 0.01), while the prevalence of high-risk HPV infection (19.97%) was significantly higher than that of low-risk genotypes (5.48%) (p < 0.01). The most prevalent high-risk genotypes were HPV52 (4.16%), HPV16 (2.98%), HPV58 (2.15%), HPV53 (1.58%) and HPV68 (1.34%). HPV co-infection with up to 10 genotypes was reported for the first time. Our findings suggested a high burden of HPV infections among women in northern Guangdong. Establishing the prevalence and genotype distribution characteristics of HPV infections in the region can contribute to cervical cancer prevention through HPV vaccination.

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Section: Discussionsupporting

confidence: 93%

The prevalence of human papillomavirus among women in northern Guangdong Province of China

Huang

et al. 2022

Sci Rep

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“…The specific mechanisms that favor HPV-16 remain a mystery to be explored, but viral genetic variation may partly explain its unique prevalence and carcinogenic properties. Besides HPV-16, the type-specific distribution between Han and Mongols revealed HPV-18,−31,−52,−58, and−59 were commonly seen among the 5 most prevalent genotypes, with variable ranking, which was consistent with prior study ( 15 ). Moreover, HPV-39 ranked in the top group in Han, as well as Mongols-WSQ.…”

Section: Discussionsupporting

confidence: 90%

“…HPV-16 and−18 together are reported to be responsible for 71% of ICC globally ( 13 ) and 84% in China ( 14 ). Even in mainland China, according to our prior study, there were disparities in the prevalence and type-specific distribution of HPV in different provinces ( 15 ). The causes for these differences are still unclear, although socioeconomic factors and behavioral risk factors have been suggested as the most possible explanations ( 16 ), biological and genetic factors should not be ignored.…”

Section: Introductionmentioning

confidence: 80%

Prevalence of Human Papillomavirus Among Chinese Han and Mongols Minority Women in Inner Mongolia, China: Reflected by Self-Collected Samples in CHIMUST

Guo

et al. 2022

Front. Public Health

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BackgroundThe disparities of hr-HPV infection among races/ethnicities have not been fully discussed. This study aimed to investigate the difference of hr-HPV infection between Chinese Han and Mongols minority women in Inner Mongolia.MethodsGenotyping and histopathology data of Chinese Han and Mongols minority women in Inner Mongolia from Chinese Multi-Center Screening Trial were used to analyze the hr-HPV prevalence, and type-specific distribution in abnormal pathology results.ResultsThe hr-HPV infection rates of Han women was 15.9% while of Mongols was 21.6% (P < 0.001). The most prevalent genotypes in Han women were ranked as HPV-16,−52,−18/-58,−31/-39, and−59 while in Mongols were−16,−31,−58,−18 and−52. When analyzing the age-specific of hr-HPV infection, two peaks were found at age of 40–44 (20.5%) and 55–59 (23.5%) years in Han women while three peaks were observed at age of 30–34 (22.1%), 45–49 (22.9%), and 55–59 (31.8%) years, respectively, in Mongols. HPV-16 accounting for 62.5 and 53.8% of the CINII+ in Han and Mongols, respectively.ConclusionThe prevalence of hr-HPV was significantly different between the Han and Mongols minority women in Inner Mongolia, races/ethnicities background should be taken into consideration for the refinement of cervical cancer screening strategies and vaccine implementation in China.

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“…Some multicenter studies have shown that geographical variations contribute to the prevalence and distribution of HPV in mainland China [ 20 , 21 ]. For the present study, we further pooled region-specific data available for China to analyze the prevalence of HPV among the different regions in China between 2008 and 2020 (Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…It remains for a large sample to be analyzed in order to verify whether the large differences in rates reported are due to different targeted HPV genotypes or populations. A population-based multicenter study showed that the prevalence of HR-HPV infections varied from 6.3 to 21.55% in China [ 20 , 21 , 37 ]. Considering the available data, we predict the mean prevalence of HPV in the overall population of China ranges from 10 to 20%.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and genotype distribution of human papillomavirus infections in Beijing, China between 2016 and 2020

Zhang

Guo

et al. 2023

Virol J

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Background Certain types of human papillomavirus (HPV) induce long-lasting infections that cause cervical cancer. This study evaluated the prevalence of HPV infections and the distribution of their genotypes among clinic patients and healthy women in Beijing, China. Methods Cervical specimens were collected from 12,100 patients and 1176 subjects who underwent physical examinations at Dongzhimen Hospital, Beijing University of Chinese Medicine, between March 2016 and September 2020. HPV genotyping was performed using commercial kits designed to detect 15 high-risk and 2 low-risk HPV genotypes. Results There was a higher overall prevalence of HPV among the clinic patients (21.0%) than among the healthy women (11.9%). The most common HPV genotypes among the patients were: HPV-52 (5.4%), HPV-16 (3.4%), HPV-58 (3.2%), HPV-51 (2.6%), HPV-39 (2.0%), HPV-56 (2.0%), and HPV-66 (2.0%). Among the healthy women: HPV-52 (3.0%), HPV-51 (1.8%), HPV-58 (1.6%), HPV-66 (1.5%), HPV-16 (1.2%), HPV-56 (1.2%), and HPV-18 (1.1%). Multiple HPVs were detected in 29.1% of the gynecological outpatients and in 23.6% of the women receiving physical examinations. The most common pairs of HPV types detected were HPV-52 and HPV-16 in the clinic patients, and HPV-52 and HPV-56 in the healthy women. Age-specific HPV positivity and peak prevalence were observed among the individuals in both groups for women aged less than 25 years and those between 61 and 65 years of age. Conclusions Our results provide current estimates of HPV prevalence and genotypes in the Beijing region. The epidemiological characteristics observed also provide a reference for the development of cervical cancer screening strategies and selection of HPV vaccine antigen targets for this region. A comparison of these HPV prevalence data with those from other regions suggests that regional vaccines may be an important direction for future research.

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The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women

Cited by 9 publications

References 44 publications

The prevalence of human papillomavirus among women in northern Guangdong Province of China

The prevalence of human papillomavirus among women in northern Guangdong Province of China

Prevalence of Human Papillomavirus Among Chinese Han and Mongols Minority Women in Inner Mongolia, China: Reflected by Self-Collected Samples in CHIMUST

Prevalence and genotype distribution of human papillomavirus infections in Beijing, China between 2016 and 2020

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