Prevalence of Human Papillomavirus Among Chinese Han and Mongols Minority Women in Inner Mongolia, China: Reflected by Self-Collected Samples in CHIMUST

Guo, Chunfang; Du, Hui; Qu, Xiaoyan; Duan, Xiaohui; Li, Jingran; Li, Ruizhen; Jin, Hua; Wang, Chun; Zhao, Chao; Bao, Juncui; Luo, Hongxue; Wei, Lihui; Belinson, Jerome L.; Wu, Ruifang

doi:10.3389/fpubh.2022.840879

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…There are also differences in HPV infection among women in different regions with different economic development levels in China. 20 According to a systematic review by Yin et al, 21 the rate of hrHPV infection caused by genotype types 16, 52, 58, 53, 18 was as high as 19.0% among women in the mainland China. Therefore, further longitudinal studies, including the prevalence and incidence screening, as well as age-stratified classification strategies in primary HPV screening, are necessary.…”

Section: Introductionmentioning

confidence: 99%

HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic

Xia

Zheng

et al. 2023

Human Vaccines & Immunotherapeutics

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Since March 2020, the pandemic caused by SARS-CoV-2 has affected nearly all aspects of daily life. In this study, we investigated the age-stratified prevalence and genotype distribution of human papillomavirus (HPV) among females in Shandong province (eastern China) and aimed to provide guidance on HPV-based cervical cancer screening and vaccination. The distribution of HPV genotypes was analyzed using PCR-Reverse Dot Hybridization. The overall infection rate of HPV was 16.4%, which was dominated by high-risk genotypes. The most prevalent genotype was HPV16 (2.9%), followed by HPV52 (2.3%), HPV53 (1.8%), HPV58 (1.5%), and HPV51 (1.3%). Among the positive cases with HPV infection, single-genotype infection was significantly higher than that of multi-genotype infection. In subgroup analyses by age (≤25, 26–35, 36–45, 46–55, >55), HPV16, 52, and 53 were consistently the three most common hrHPV genotypes in all age groups. The infection rate of multi-genotypes in the ≤25 and >55 age groups was significantly higher than that in other age groups. A bimodal distribution of HPV infection rate was observed in different age groups. Among lrHPV genotypes, HPV6, HPV11, and HPV81 were the three most common types in the ≤25 age group, while in other age groups, HPV81, HPV42, and HPV43 are the three most common lrHPV genotypes. This study provides basic information on the distribution and genotypes of HPV in the female population in eastern China, which could improve the application of HPV diagnostic probes and vaccines.

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Section: Introductionmentioning

confidence: 99%

HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic

Xia

Zheng

et al. 2023

Human Vaccines & Immunotherapeutics

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“…Even when we stratified the women into simple and mixed infection groups, this pattern remained consistent. HPV infection is closely related to women’s age, and women who are sexually active and postmenopausal women have a higher probability of infection with HPV ( 37 , 40 , 41 ), which is also applicable in the Nagqu area. This may be related to factors such as age at first sexual encounter, number of sexual partners, frequency of sexual intercourse, and sexual hygiene for sexually active women ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Cervical cancer screening in high-altitude areas in China: A large cross-section study of 25,173 women in northern Tibet

Wang

Long

et al. 2022

Front. Oncol.

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BackgroundCervical cancer has become a worldwide concern owing to its high incidence and mortality rates. To date, high-altitude areas of Tibet have not benefited from any large-scale cervical cancer screening programs. Therefore, we initiated a screening program to investigate the prevalence of human papilloma virus (HPV) and HPV genotype distribution to reveal cervical cancer and its precursor which lead to morbidity among women in the city of Nagqu in northern Tib3et.MethodsA total of 25,173 women were recruited to undergo HPV genotype tests between June and December 2019. Women infected with HPV 16 and/or 18 underwent colposcopy and histological examination. Women with other high-risk HPV type (hr-HPV) underwent cytological tests to determine whether to conduct further colposcopy and histological examination for diagnosis. HPV prevalence was calculated in the total population and further stratified according to various parameters, such as age group, area location (altitude level), and single or mixed infection status. The HPV genotype distribution was also investigated accordingly. Cervical lesions revealed by further colposcopic findings were also analyzed; high-grade and malignant lesion morbidities were calculated in total and in each county. Most data were collected and analyzed using descriptive and consistency check statistical methods, and a risk factor investigation for HPV infection was performed using logistic regression models.ResultsThe total HPV infection rate among women in Nagqu was 13.42%. Of the 25,173 women in the study, 999 (3.97%) were HPV 16/18 positive, 2,379 (9.45%) were other hr-HPV-positive, and 21,795 (86.58%) were HPV-negative. The five most common HPV genotypes, accounting for more than 60% of all HPV infections in Nagqu people, were HPV 16, 58, 31, 18, and 52. Tibetan women younger than 20 years and older than 60 years were the two age groups with the highest rates of HPV infection, 26.7% and 19.8%, respectively. Among the HPV-positive women, 2,656 (78.33%) were infected with a single strain and 732 (21.67%) were infected with multiple strains (more than two genotypes). HPV prevalence increased in high-altitude areas (positive rate highest in Nyima with an altitude of 5,000 m, 23.9%) and decreased in relatively low-altitude areas (positive rate lowest in Lhari with an altitude of 4,000 m, 6.6%). Multiple analyses showed that age, parity, age at first delivery, and altitude of residence were independent factors facilitating HPV infection in Tibetan women. High-grade and malignant cervical lesions revealed by histological findings were different among living locations, with the highest rates in Xainza, Baingoin, and Nyainrong, these being 2.019%, 1.820%, and 1.116%, respectively, among women in these areas.ConclusionOur survey provides an overall perspective on HPV genotype infection and cervical lesions in women in northern Tibet. The data not only provide useful information for the treatment of cervical lesions but also has great value in terms of the primary and secondary prevention measures that can be taken for women living in these regions.Clinical Trial Registrationwww.chictr.org.cn, indentifier ChiCTR2000035061.

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“…Despite Ordos City having a high economic level, our study found that it still experiences a moderate HPV infection rate (estimated gross regional product (GDP) per capita of ￥256,908 (approximately $36,300) [ 10 ]). This occurrence can be attributed to Ordos City being a vast region with a certain proportion of herdsmen and ethnic minorities, mainly Mongolian, who may possess limited knowledge about HPV and endure a higher disease burden [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of human papillomavirus prevalence and infection patterns among women aged 25–64 according to age groups and cytology results in Ordos City, China

Wang,

Liu,

Tan

et al. 2024

Virol J

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Background The assessment of human papillomavirus (HPV) genotype distribution in terms of age and cervical lesions could contribute to the adoption of more targeted preventive approaches to specific populations against cervical cancer. The current study was conducted in Ordos City, China, with the aim of analyzing the HPV genotypes prevalence and infection patterns within a hospital-based population. Methods The analysis included a total of 26,692 women aged 25–64 who underwent cervical cancer screening between January 1st, 2019, and June 30th, 2022, in Ordos City. These women had valid results for both the polymerase chain reaction (PCR)-reverse dot blot (RDB) HPV test and the liquid-based cytology (thinprep cytologic test/TCT). Data were extracted from the database of KingMed Diagnostics laboratories. The prevalence of HPV genotypes within different age groups and cytology diagnoses were calculated. Results Among 26,692 women, 7136 (26.73%) women were HPV positive, 5696 (21.34%) women were high-risk HPV (HR-HPV) positive, and 2102 (7.88%) women had multiple HPV infections. The most frequently detected HPV genotypes were HPV16 (4.72%) and HPV52 (4.15%), ranking as the first and second most prevalent genotypes, respectively. The prevalence of HR-HPV increased with age groups and severity of cervical lesions. Notably, the positive rate of HR-HPV among women aged 35–64 years showed a decreasing trend over the respective years, ranging from 26.00 to 19.70% (Ptrend < 0.001). Conclusion In conclusion, the epidemiology of HPV genotypes partly reflects the effectiveness of regional cervical cancer prevention and control efforts in the past. These findings can inform future initiatives concerning HPV vaccination and screening in the region.

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Prevalence of Human Papillomavirus Among Chinese Han and Mongols Minority Women in Inner Mongolia, China: Reflected by Self-Collected Samples in CHIMUST

Cited by 4 publications

References 34 publications

HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic

HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic

Cervical cancer screening in high-altitude areas in China: A large cross-section study of 25,173 women in northern Tibet

Characteristics of human papillomavirus prevalence and infection patterns among women aged 25–64 according to age groups and cytology results in Ordos City, China

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