The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes

Krętowski, Adam; Hokanson, John E.; McFann, Kim; Kinney, Gregory L.; Snell‐Bergeon, Janet K.; Maahs, David M.; Wadwa, R. Paul; Eckel, Robert H.; Ogden, Lorraine G.; Garg, Samita; Li, J.; Cheng, Suzanne; Erlich, Henry A.; Rewers, Marian

doi:10.1007/s00125-006-0317-1

Cited by 28 publications

(15 citation statements)

References 49 publications

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“…Although no one has identified candidate genes associated with the rate of progression of CAC, others have identified candidate genes associated with CAC progression when defined as a qualitative trait (ie, progressors versus nonprogressors 29 ) in individuals with type 1 diabetes. 30,31 It would be important to investigate whether any identified genes are unique for CAC progression or whether they also are associated with cross-sectional measures of CAC prevalence or quantity.…”

Section: Discussionmentioning

confidence: 99%

Coronary Artery Calcification Progression Is Heritable

et al. 2007

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Background-Coronary artery calcification (CAC), a marker of coronary artery atherosclerosis, can be measured accurately and noninvasively with the use of electron beam computed tomography. Serial measures of CAC quantify progression of calcified coronary artery plaque. Little is known about the role of genetic factors in progression of CAC quantity. Methods and Results-We quantified the relative contributions of measured risk factors and unmeasured genes to CAC progression measured by 2 electron beam computed tomography examinations an average of 7.3 years apart in 877 asymptomatic white adults (46% men) from 625 families in a community-based sample. After adjustment for baseline risk factors and CAC quantity, the estimated heritability of CAC progression was 0.40 (PϽ0.001). Baseline risk factors and CAC quantity explained 64% of the variation in CAC progression. Thus, genetic factors explained 14% of the variation [(100Ϫ64)ϫ(0.40)] in CAC progression. After adjustment for risk factors, the estimated genetic correlation (pleiotropy) between baseline CAC quantity and CAC progression was 0.80 and was significantly different than 0 (PϽ0.001) and 1 (Pϭ0.037). The environmental correlation between baseline CAC quantity and CAC progression was 0.42 and was significantly different than 0 (Pϭ0.006). Conclusions-Evidence was found that many but not all genetic factors influencing baseline CAC quantity also influence CAC progression. The identification of common and unique genetic influences on these traits will provide important insights into the genetic architecture of coronary artery atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Coronary Artery Calcification Progression Is Heritable

et al. 2007

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“…A common polymorphism (glutamine to histidine at position 360 near the carboxyl terminus) generates two isoforms, apoA-IV1 (360Gln) and apoA-IV2 (360His). The latter has been associated with a significantly higher risk of subclinical CAD progression (relative risk 3.3, P ϭ 0.003) in type 1 diabetic patients (120) and MI in type 2 diabetic patients (121) but not in nondiabetic control subjects (120).…”

Section: Hepatic Lipasementioning

confidence: 99%

Type 1 Diabetes and Coronary Artery Disease

et al. 2006

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“…Enhanced cholesterol effl ux from cultured macrophage and fi broblasts to medium with recombinant or purifi ed apoA-IV, or lipid-free serum from apoA-IV transgenic mice only a few clinical studies have investigated its linkage to diseases of glucose metabolism and energy utilization (30)(31)(32). Further studies of this type may now be warranted by the newer fi ndings showing a role for apoA-IV in glucose metabolism, as will be discussed later.…”

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confidence: 99%