The “Anxiety State” and Its Relation with Rat Models of Memory and Habituation

Ribeiro, Rafaela Larsen; Andreatini, Roberto; Wolfman, Claudia; Viola, Haydeé; Medina, Jorge H.; Cunha, Cláudio Da

doi:10.1006/nlme.1998.3891

Cited by 47 publications

(30 citation statements)

References 56 publications

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“…Claudio Da Cunha: In my laboratory we did some experiments showing that anxious and non-anxious rats present correlated behavior in learning and memory tasks (18). I suppose this is in agreement with Jean-Marcs view of an interconnected network.…”

Section: What Kinds Of Research Are Needed To Resolve These Controversupporting

confidence: 68%

The brain decade in debate: III. Neurobiology of emotion

Blanchard

Fellous³

et al. 2001

Braz J Med Biol Res

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This article is a transcription of an electronic symposium in which active researchers were invited by the Brazilian Society of Neuroscience and Behavior (SBNeC) to discuss the advances of the last decade in the neurobiology of emotion. Four basic questions were debated: 1) What are the most critical issues/questions in the neurobiology of emotion? 2) What do we know for certain about brain processes involved in emotion and what is controversial? 3) What kinds of research are needed to resolve these controversial issues? 4) What is the relationship between learning, memory and emotion? The focus was on the existence of different neural systems for different emotions and the nature of the neural coding for the emotional states. Is emotion the result of the interaction of different brain regions such as the amygdala, the nucleus accumbens, or the periaqueductal gray matter or is it an emergent property of the whole brain neural network? The relationship between unlearned and learned emotions was also discussed. Are the circuits of the former the underpinnings of the latter? It was pointed out that much of what we know about emotions refers to aversively motivated behaviors, like fear and anxiety. Appetitive emotions should attract much interest in the future. The learning and memory relationship with emotions was also discussed in terms of conditioned and unconditioned stimuli, innate and learned fear, contextual cues inducing emotional states, implicit memory and the property of using this term for animal memories. In a general way it could be said that learning modifies the neural circuits through which emotional responses are expressed.

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Section: What Kinds Of Research Are Needed To Resolve These Controversupporting

confidence: 68%

The brain decade in debate: III. Neurobiology of emotion

Blanchard

Fellous³

et al. 2001

Braz J Med Biol Res

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“…Numerous findings in animal and human studies provide considerable evidence that anxiety and memory are two closely linked entities (Beuzen and Belzung 1995;McGaugh 2004). Memory formation and anxiety processes may interact by using some common neural substrates or by modulating each other in an adaptive way (Ribeiro et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and β-CCt

et al. 2005

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“…The fact that various neuropharmacological substances have anxiolytic as well as amnestic effects suggests that neuronal mechanisms of anxiety, learning and memory closely interact (25,26). Ribeiro et al (25) reported that anxious rats perform better in passive avoidance tasks and worse in active avoidance tasks.…”

Section: Discussionmentioning

confidence: 99%

“…Ribeiro et al (25) reported that anxious rats perform better in passive avoidance tasks and worse in active avoidance tasks. In contrast, FernandezTeruel et al (27) showed that non-anxious rats present a larger number of avoidance scores in the shuttle box.…”

Section: Discussionmentioning

confidence: 99%

Behavioral characteristics of the offspring of adolescent rats

Zemunik

Peruzović

Čapkun³

et al. 2003

Braz J Med Biol Res

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The aim of this study was to test the hypothesis that, during adulthood, the offspring of adolescent rats differ in emotionality, learning and memory from the offspring of adult rats. The behavior of the offspring of adolescent (age, 50-55 days) and adult rats (age, 90-95 days) was tested in the open field, activity cage, and passive and active avoidance apparatus. The latencies during training and testing in the passive avoidance apparatus of the offspring of adolescent parents were shorter than the latencies of control offspring (P<0.001 on both training and testing days). Offspring of adolescent parents showed shorter latency time in acquisition trials during active avoidance testing compared to control offspring (P<0.001). They also showed a higher number of active avoidance responses in the last four blocks of acquisition (P<0.001) and first two blocks of extinction trials (P<0.05 and P<0.001, respectively). The offspring of adolescent parents showed higher latency on the first day of testing in the open field (P<0.01) and a lower latency on the third day of testing (P<0.01). They also showed higher activity during all three days of testing (1st and 2nd day: P<0.01; 3rd day: P<0.05). The spontaneous activity of the offspring of adolescent parents in the activity cage was higher in the last three intervals of testing (P<0.001). In summary, the offspring of adolescent parents were less anxious and tended to be more active. The results of two learning and memory tests were opposite, but could be explained by a higher exploratory drive of the offspring of adolescent parents. This was probably due to chronic malnutrition stress and the disturbed mother-infant relationship in the litters of adolescent mothers. Correspondence

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The “Anxiety State” and Its Relation with Rat Models of Memory and Habituation

Cited by 47 publications

References 56 publications

The brain decade in debate: III. Neurobiology of emotion

The brain decade in debate: III. Neurobiology of emotion

Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and β-CCt

Behavioral characteristics of the offspring of adolescent rats

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