The antithrombotic and thrombolytic activity of tuftsin

Lyapina, L. A.; Pastorova, V. E.; Kondashevskaya, M. V.; Kudryashov, B. A.; Kalikhevich, V. N.; Каменский, А. А.; Ашмарин, И. П.

doi:10.1007/bf00805131

Cited by 2 publications

(1 citation statement)

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“…In lieu of the present study and with our earlier findings, FA possesses both thrombolytic and anticoagulant activities. There are other natural products and their components that possess both anticoagulant and thrombolytic properties such as onion, 47 Paeonia anomala extract, 48 tuftsin, 49 Paeonia lutea root bark, 50 danshen (Salvia miltiorrhiza), 51 and meadowsweet (Filipendula ulmaria (L) Maxim.). [52][53][54] The FA could be a better agent for curing patients with thrombosis, as it would act as both a clot dissolver and an anticoagulant agent.…”

Section: Phytoconstituentmentioning

confidence: 99%

Effect of Aqueous Extract and Fractions of Fagonia arabica on In Vitro Anticoagulant Activity

Chourasia

Kashyap

Deopujari

et al. 2013

Clin Appl Thromb Hemost

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Fagonia arabica (FA) is a deobstruent and blood purifier, which possesses thrombolytic and antioxidant activities. In this study, the anticoagulant effects of FA and its derived fractions were evaluated. Plasma recalcification was performed with multisolvent extracts of FA and then with extracts prepared successively with increasing polarity of the solvents. Aqueous extract was the most potent anticoagulant extract, which was fractionated by thin-layer chromatography and column chromatography. Five fractions collected were checked for their anticoagulation effect. The most potent fraction was screened for phytoconstituents. Aqueous extract of FA is the most active anticoagulant (31 minutes). Results were statistically significant when compared to heparin (38 minutes) and saline (4.04 minutes; P > .001). The Fifth fraction (FA5), the most potent fraction (27 minutes), was found positive for flavonoids, saponin, tannin, triterpenoids, carbohydrates, reducing sugar, and monosaccharides. Aqueous FA and fraction FA5 were most active in in vitro anticoagulation, and any of the phytochemicals identified could be considered the active component.

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Section: Phytoconstituentmentioning

confidence: 99%