The Antioxidant Rosmarinic Acid Ameliorates Oxidative Lung Damage in Experimental Allergic Asthma via Modulation of NADPH Oxidases and Antioxidant Enzymes

Liang, Zhengmin; Wu, Liqin; Deng, Xin; Liang, Qiuling; Xu, Yangfeng; Deng, Ruihan; Lv, Li; Ji, Min; Hao, Zhihui; He, Jiakang

doi:10.1007/s10753-020-01264-3

Cited by 27 publications

(14 citation statements)

References 44 publications

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“…These findings are correlated with our previous reports that the extracts from perilla reduced oxidative stress [22,68]. Additionally, RA decreased the level of ROS in RAW macrophages and asthma mouse models [69,70]. Collectively, our results indicate that RA-RF can suppress intracellular ROS generation in PMFF-stimulated A549 cells, and thus may protect against oxidative stress and injury in lung epithelial cells induced by air pollution.…”

Section: Discussionsupporting

confidence: 92%

Suppressive Effects of Rosmarinic Acid Rich Fraction from Perilla on Oxidative Stress, Inflammation and Metastasis Ability in A549 Cells Exposed to PM via C-Jun, P-65-Nf-Κb and Akt Signaling Pathways

et al. 2021

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Particulate matter from forest fires (PMFF) is an environmental pollutant causing oxidative stress, inflammation, and cancer cell metastasis due to the presence of polycyclic aromatic hydrocarbons (PAHs). Perilla seed meal contains high levels of polyphenols, including rosmarinic acid (RA). The aim of this study is to determine the anti-oxidative stress, anti-inflammation, and anti-metastasis actions of rosmarinic acid rich fraction (RA-RF) from perilla seed meal and its underlying molecular mechanisms in A549 cells exposed to PMFF. PMFF samples were collected via the air sampler at the University of Phayao, Thailand, and their PAH content were analyzed using GC-MS. Fifteen PAH compounds were detected in PMFF. The PMFF significantly induced intracellular reactive oxygen species (ROS) production, the mRNA expression of pro-inflammatory cytokines, MMP-9 activity, invasion, migration, the overexpression of c-Jun and p-65-NF-κB, and Akt phosphorylation. Additionally, the RA-RF significantly reduced ROS production, IL-6, IL-8, TNF-α, and COX-2. RA-RF could also suppress MMP-9 activity, migration, invasion, and the phosphorylation activity of c-Jun, p-65-NF-κB, and Akt. Our findings revealed that RA-RF has antioxidant, anti-inflammatory, and anti-metastasis properties via c-Jun, p-65-NF-κB, and Akt signaling pathways. RA-RF may be further developed as an inhalation agent for the prevention of lung inflammation and cancer metastasis induced by PM exposure.

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Section: Discussionsupporting

confidence: 92%

Suppressive Effects of Rosmarinic Acid Rich Fraction from Perilla on Oxidative Stress, Inflammation and Metastasis Ability in A549 Cells Exposed to PM via C-Jun, P-65-Nf-Κb and Akt Signaling Pathways

et al. 2021

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“…32,33 With an acid dissociation constant K a of 10 À3 , 57 mono-anionic RA À is the main form of RA existing in the physiological environment (pH ranging from 7.35 to 7.45). 34 Rosmarinic acid also shows a large number of biological and pharmacological activities including anti-myotoxic, 35 antioxidant, [36][37][38][39][40] anti-inammatory, 26 antimicrobial, 41 anti-mutagenic, 42 anti-cancer, 43 antibacterial, 44 and antiviral 27 functions. Moreover, RA is able to interact with several high-molecular weight compounds such as proteins and lipids.…”

Section: Introductionmentioning

confidence: 99%

“…Among the biological activities of RA, its antioxidant activity has been investigated via both experimental and computational approaches. [36][37][38][39][40] For example, Fadel et al experimentally studied the antioxidant activity of RA in preventing lipid peroxidation. 36 The authors measured the peroxidation of liposomes of 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) at 37 C with a hydrophilic radical generator, namely, 2,2 0 -azo-bis(2amidinopropane)dihydrochloride (AAPH).…”

Section: Introductionmentioning

confidence: 99%

New insights into the competition between antioxidant activities and pro-oxidant risks of rosmarinic acid

et al. 2022

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“…In another study reported by the same group, RA treatment significantly diminished inflammatory cells, upregulated SOD, glutathione peroxidase, and CAT activities, and a notable reduction in NOX-2 and NOX-4 expression in lung tissues. RA ameliorated oxidative lung injury and airway inflammation in asthmatic models (Liang et al 2020 ). RA exhibited protective action against malathion (pesticide) induced lung damage through anti-inflammatory, antioxidant, and anti-apoptotic functions in albino Wistar rat models (Ahmed et al 2021 ).…”

Section: Pharmacological Properties Of Ramentioning

confidence: 99%

Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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The Antioxidant Rosmarinic Acid Ameliorates Oxidative Lung Damage in Experimental Allergic Asthma via Modulation of NADPH Oxidases and Antioxidant Enzymes

Cited by 27 publications

References 44 publications

Suppressive Effects of Rosmarinic Acid Rich Fraction from Perilla on Oxidative Stress, Inflammation and Metastasis Ability in A549 Cells Exposed to PM via C-Jun, P-65-Nf-Κb and Akt Signaling Pathways

Suppressive Effects of Rosmarinic Acid Rich Fraction from Perilla on Oxidative Stress, Inflammation and Metastasis Ability in A549 Cells Exposed to PM via C-Jun, P-65-Nf-Κb and Akt Signaling Pathways

New insights into the competition between antioxidant activities and pro-oxidant risks of rosmarinic acid

Biomedical features and therapeutic potential of rosmarinic acid

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