The antimicrobial effectiveness of photodynamic therapy used as an addition to the conventional endodontic re-treatment: A clinical study

Jurič, Ivona Bago; Plečko, Vanda; Pandurić, Dragana Gabrić; Anić, Ivica

doi:10.1016/j.pdpdt.2014.10.004

Cited by 52 publications

(64 citation statements)

References 33 publications

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“…Various studies have reported the antibacterial efficacy of PDT and have stated that PDT can be used safely without harming the host tissue (29)(30)(31)(32)(33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Efficiency of Different Irrigation Solutions, Lasers and Photodynamic Therapy with Indocyanine Green in Root Canals Infected By <i>Enterococcus Faecalis</i>

Ozkocak¹,

Göktürk²,

Çoşkun³

et al. 2018

meandros

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Objective: The aim of this study was to evaluate bacterial reduction after using different irrigants, lasers and photodynamic therapy (PDT) in root canals infected by Enterococcus faecalis. Materials and Methods: Seventy human maxillary incisors were used in this study. After endodontic preparation, sixty teeth were infected by 20 µl E. faecalis (ATCC 29212) and specimens were incubated for 72 hours. Groups were formed according to the irrigation protocol used: group 1: negative control, group 2: positive control, group 3: 10 mL 2% chlorhexidine (CHX), group 4: 10 mL 5% NaOCl, group 5: diode laser, group 6: Er:YAG laser, and group 7: indocyanine green (ICG)-diode laser (PDT). After disinfection procedures the samples isolated from root canals were placed into blood agar, incubated at 37 °C for 24 h and then were counted for colony-forming units. One-Way ANOVA was used for the statistical evaluation of data. For multiple comparisons, Tamhane's T2 test was used. Results: All investigated disinfection procedures had a significant reduction in the bacterial population (p<0.001). CHX, NaOCl and ICG-diode laser groups were equally effective in reducing E. faecalis populations (p>0.05) and statistically more effective than both laser groups (p<0.05). Conclusion: Promising results were obtained by using PDT with ICG. This alternative disinfection method found effective on E. faecalis. Amaç: Bu çalışmanın amacı, Enterococcus faecalis ile enfekte edilmiş kök kanallarında farklı irrigasyon solüsyonları, lazerler ve fotodinamik tedavi (FDT) kullandıktan sonra bakteri sayısındaki azalmayı değerlendirmektir. Gereç ve Yöntemler: Bu çalışmada yetmiş adet insan üst çene kesici dişi kullanıldı. Kök kanal preparasyonundan sonra altmış diş 20 μL E. faecalis (ATCC 29212) ile

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“…Various studies have reported the antibacterial efficacy of PDT and have stated that PDT can be used safely without harming the host tissue (29)(30)(31)(32)(33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Efficiency of Different Irrigation Solutions, Lasers and Photodynamic Therapy with Indocyanine Green in Root Canals Infected By <i>Enterococcus Faecalis</i>

Ozkocak¹,

Göktürk²,

Çoşkun³

et al. 2018

meandros

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“…In the second study, the authors used the same aPDT protocol in endodontic subjects treated surgically and assessed bacterial reduction and periapical healing. After 36 months of follow-up, they reported that aPDT associated with conventional procedures leads to a 5 log bacterial reduction and a mean reduction of about 78% of periapical lesions size (Garcez, Arantes-Neto, Sellera, & Fregnani, 2015 noted that aPDT was effective in eliminating microbial burden within the root canals in these patients (Juric, Plecko, Panduric, & Anic, 2014).…”

Section: Antimicrobial Photodynamic Therapy Applications In Endodonmentioning

confidence: 99%

“…HELBO, 660 nm diode laser, 1 min, 100 mW) associated with conventional endodontic retreatment in 21 single‐rooted teeth that presented with apical periodontitis. Post‐treatment microbiological analysis results noted that aPDT was effective in eliminating microbial burden within the root canals in these patients (Juric, Plecko, Panduric, & Anic, ). In another long follow‐up study, Johns et al.…”

Section: Photodynamic Therapy In Oral Diseasesmentioning

confidence: 99%

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

et al. 2018

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This narrative review on the use of biophotonics therapies for management of oral diseases is written as a tribute to Prof. Crispian Scully. His seminal contributions to the field are highlighted by the detailed, comprehensive description of clinical presentations of oral diseases. This has enabled a more thorough, fundamental understanding of many of these pathologies by research from his group as well as inspired mechanistic investigations in many groups globally. In the same vein, a major emphasis of this narrative review is to focus on the evidence from human case reports rather than in vitro or in vivo animal studies that showcases the growing and broad impact of biophotonics therapies. The similarities and differences between two distinct forms of low-dose biophotonics treatments namely photodynamic therapy and photobiomodulation therapy are discussed. As evident in this review, a majority of these reports provide promising evidence for their clinical efficacy. However, a lack of adequate technical details, precise biological rationale, and limited outcome measures limits the current utility of these treatments. Future investigations should attempt to address these shortcomings and develop better designed, rigorous, controlled studies to fully harness the tremendous potential of low-dose biophotonics therapies.

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“…Dessa forma, o tratamento endodôntico deve ser realizado como medida para eliminar e inativar os biofilmes bacterianos e seus subprodutos facilitando assim a reparação dos tecidos apicais 1,3 . Durante o preparo químico mecânico utiliza-se instrumentos manuais ou mecanizados, concomitante a irrigação com substâncias químicas, e em alguns casos, o uso de medicação intra-canal entre as sessões clínicas, obtendo assim relativas taxas de sucesso na diminuição da quantidade de bacté-rias presentes nos canais radiculares 2,4,5,6 . Está bem evidenciado na atual literatura, que a desinfecção completa dos canais radiculares é bastante difícil, devido à diversidade dos sistemas de canais radiculares na região apical onde há maior predomínio de deltas apicais e formação de biofilme extraradicular, o que dificulta a eliminação de micro-organismos resistentes, tal como o Enterococcus Facaelis 5,7,8 .…”

Section: Introductionunclassified

“…Durante o preparo químico mecânico utiliza-se instrumentos manuais ou mecanizados, concomitante a irrigação com substâncias químicas, e em alguns casos, o uso de medicação intra-canal entre as sessões clínicas, obtendo assim relativas taxas de sucesso na diminuição da quantidade de bacté-rias presentes nos canais radiculares 2,4,5,6 . Está bem evidenciado na atual literatura, que a desinfecção completa dos canais radiculares é bastante difícil, devido à diversidade dos sistemas de canais radiculares na região apical onde há maior predomínio de deltas apicais e formação de biofilme extraradicular, o que dificulta a eliminação de micro-organismos resistentes, tal como o Enterococcus Facaelis 5,7,8 . O tratamento endodôntico convencional falha na inativação e eliminação das endotoxinas bacterianas como os lipopolissacarídeos que são liberados provocando infecções endodônticas graves que comprometem o sucesso da terapia endodôntica 2,6 .…”

Section: Introductionunclassified

Análise do uso da terapia fotodinâmica no tratamento endodôntico com base em um Congresso Odontológico

Santos

Brito²,

Neves³

et al. 2017

Rev. da Fac. de Odontologia, UPF

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Um dos objetivos do tratamento endodôntico é a máxi-ma desinfecção do sistema de canais radiculares, bem como, a prevenção da sua reinfecção. A terapia fotodi- IntroduçãoA infecção endodôntica ocorre com a proliferação de bactérias no interior dos canais radiculares que adentraram nesse meio através da exposição do dente ao ambiente oral, devido a lesões cariosas ou traumáticas, causando a formação de lesões perirradiculares persistentes 1,2 . Dessa forma, o tratamento endodôntico deve ser realizado como medida para eliminar e inativar os biofilmes bacterianos e seus subprodutos facilitando assim a reparação dos tecidos apicais 1,3 . Durante o preparo químico mecânico utiliza-se instrumentos manuais ou mecanizados, concomitante a irrigação com substâncias químicas, e em alguns casos, o uso de medicação intra-canal entre as sessões clínicas, obtendo assim relativas taxas de sucesso na diminuição da quantidade de bacté-rias presentes nos canais radiculares 2,4,5,6 . Está bem evidenciado na atual literatura, que a desinfecção completa dos canais radiculares é bastante difícil, devido à diversidade dos sistemas de canais radiculares na região apical onde há maior predomínio de deltas apicais e formação de biofilme extraradicular, o que dificulta a eliminação de micro-organismos resistentes, tal como o Enterococcus Facaelis 5,7,8 . O tratamento endodôntico convencional falha na inativação e eliminação das endotoxinas bacterianas como os lipopolissacarídeos que são liberados provocando infecções endodônticas graves que comprometem o sucesso da terapia endodôntica 2,6 .

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The antimicrobial effectiveness of photodynamic therapy used as an addition to the conventional endodontic re-treatment: A clinical study

Cited by 52 publications

References 33 publications

Antibacterial Efficiency of Different Irrigation Solutions, Lasers and Photodynamic Therapy with Indocyanine Green in Root Canals Infected By <i>Enterococcus Faecalis</i>

Antibacterial Efficiency of Different Irrigation Solutions, Lasers and Photodynamic Therapy with Indocyanine Green in Root Canals Infected By <i>Enterococcus Faecalis</i>

Learning from clinical phenotypes: Low‐dose biophotonics therapies in oral diseases

Análise do uso da terapia fotodinâmica no tratamento endodôntico com base em um Congresso Odontológico

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